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Filtered Search Results
Medchemexpress LLC GSK4112 (SR6452) | 1216744-19-2 | 99.9% | C18H21ClN2O4S | 100 MG
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GSK4112, also known as SR6452, is identified as a Rev-erbα agonist with an EC50 value of 0.4 μM. It serves as a valuable chemical tool for investigating the role of Rev-erbα in various biological processes, including transcriptional repression, the regulation of circadian rhythms, and metabolic pathways.
- Interacts with Rev-erbα with an EC50 of 0.4 μM.
- Represses the expression of bmal1 and target genes associated with gluconeogenesis, recruits HDAC3, and modulates Rev-erbα's effect on hepatic gene expression oscillation.
- Reduces glucose output in murine hepatocytes.
- Attenuates Fas-induced hepatic damage in male C57BL/6 mice.
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Research Products International Corp G-418 Disulfate, 25 Grams
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G-418 Disulfate, also known as Geneticin, is an aminoglycoside antibiotic derived from Micromonospora rhodorangea. It is widely used in molecular biology and cell culture as a selective agent. G-418 inhibits protein synthesis by targeting the 80S ribosome, blocking translocation. It is commonly used to select genetically modified cells that carry a G-418 resistance gene, typically introduced via plasmid vectors. This allows for the isolation and maintenance of stable transfectants in gene expression, protein production, and cell line development studies. Its selectivity makes it a key tool in genetic engineering.
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Medchemexpress LLC HY-B0430A 100mg Medchemexpress, D-Pantothenic acid (sodium) CAS:867-81-2 Purity:>98%
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Medchemexpress, HY-B0430A 100mg D-Pantothenic acid (sodium) CAS:867-81-2 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC HY-101792 10mg Medchemexpress, RG7800 CAS:1449598-06-4 Purity:>98%
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Medchemexpress, HY-101792 10mg RG7800 CAS:1449598-06-4 RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC 4-(2′-aminoethyl)amino-1,8-dimethylimidazo[1,2-a]quinoxaline | 445430-58-0 | MFCD18089812 | 99.7% | 255.32 g·mol⁻1 | C14H17N5 | 25 MG
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BMS-345541 is a small-molecule research reagent that selectively inhibits the catalytic subunits of IκB kinase (IKK). It binds an allosteric site on IKK and is used to probe NF-κB signaling pathways in biochemical and cellular studies. The compound is supplied with analytical characterization for research use only.
- Selective inhibition of IKK catalytic subunits, with greater potency for IKK-2
- Binds an allosteric site on the IKK enzyme
- Reported IC50 values: IKK-2 = 0.3 μM; IKK-1 = 4 μM
- High analytical purity suitable for research applications
- Available in multiple pack sizes, including 25 MG
- Molecular formula C14H17N5 and molecular weight 255.32 g·mol⁻1
- Offered as solid and as ready-to-use DMSO solution formats
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Apexbio Technology LLC OLIGOMYCIN COMPLEX 5MG
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OLIGOMYCIN COMPLEX 5MG APEXBIO TECHNOLOGIES
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Medchemexpress LLC Anhydrotetracycline hydrochloride | 13803-65-1 | ≥98.0% | 462.88 | C22H23ClN2O7 | 10 MG
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Anhydrotetracycline hydrochloride is a tetracycline-family antibiotic supplied as an analytical reference standard for laboratory research. It is commonly used as an effector in tetracycline-regulated gene expression systems and for analytical method development. The material is provided as the hydrochloride salt with molecular weight 462.88 g·mol⁻1 and chemical formula C22H23ClN2O7.
- Reference standard for research and analytical applications.
- Acts as an effector in tetracycline-regulated gene expression systems.
- Supplied as a hydrochloride salt; formula C22H23ClN2O7 and MW 462.88 g·mol⁻1.
- High reported purity (≥98%) suitable for analytical work.
- Available in small laboratory pack sizes (e.g., 10 MG, 50 MG).
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Medchemexpress LLC HY-114226 5mg Medchemexpress, Olutasidenib CAS:1887014-12-1 Purity:>98%
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Medchemexpress, HY-114226 5mg Olutasidenib CAS:1887014-12-1 Olutasidenib (FT-2102) is a highly potent, orally active, brain penetrant and selective inhibitor of mutant Isocitrate dehydrogenase 1 (IDH1), with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively . Olutasidenib (FT-2102) is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Apexbio Technology LLC SJB2-043 63388-44-3 5mg
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SJB2-043 (CAS 63388-44-3) is a small molecule inhibitor of ubiquitin-specific protease 1 (USP1) a deubiquitinating enzyme involved in the regulation of DNA repair by deubiquitinating key proteins in the Fanconi anemia (FA) pathway SJB2-043 exhibits an IC50 of 0 544 M for USP1 In cellular models such as K562 leukemia cells and primary AML cells SJB2-043 reduces USP1 levels and promotes proteasomal degradation of ID1 as well as decreasing ID2 and ID3 protein levels Treatment with SJB2-043 also increases Ub-FANCD2 and Ub-PCNA in HeLa cells reflecting modulation of DNA repair processes This compound serves as a valuable tool for studies investigating USP1 function and the regulation of ID proteins in cancer and stem cell biology
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STEMCELL Technologies Bleomycin (Sulfate), Size: 5 mg
Bleomycin is a glycopeptide-derived antibiotic, isolated from the bacterium Streptomyces verticillus, that creates DNA strand scission and exhibits antitumor activity against squamous cell carcinomas and malignant lymphomas (Galm et al.). Bleomycin induces lung injury leading to acute inflammatory response and pulmonary fibrosis (Kulkarni et al.). This product is supplied as the sulfate salt of the molecule.CANCER RESEARCH· Induces single- and double-strand DNA breaks in tumor cells (Hecht).DISEASE MODELING· Induces lung fibrosis in mice (Kulkarni et al.).
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Medchemexpress LLC HY-101404A 10mg Medchemexpress, L-Homocysteine thiolactone (hydrochloride) CAS:31828-68-9 Purity:>98%
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Medchemexpress, HY-101404A 10mg L-Homocysteine thiolactone (hydrochloride) CAS:31828-68-9 L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of homocysteine; prevents translational incorporation of homocysteine into proteins. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Menin-MLL inhibitor 20 | 2448173-47-3 | 98.8% | 50 MG
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Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities. The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, including the mixed-lineage leukaemia (MLL) family, methylate lysine 4 on histone H3 tails, which is crucial for modulating chromatin structures and DNA accessibility and plays an important role in gene expression regulation during early development and hematopoiesis. This product is for research use only.
- Irreversible menin-MLL interaction inhibitor
- Exhibits antitumor activities
- Modulates chromatin structures and DNA accessibility
- Plays an important role in gene expression regulation
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eMolecules 128517-07-7 | Romidepsin | Broadpharm | MFCD18433404 | 540.690 | C24H36N4O6S2 | 0.000 | C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C | 5mg | 795361433
Romidepsin | Broadpharm | 128517-07-7 | MFCD18433404 | 540.690 | C24H36N4O6S2 | 0.000 | C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C | 5mg | 795361433
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Medchemexpress LLC HY-B0274 50mg Medchemexpress, Chlorprothixene CAS:113-59-7 Purity:>98%
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Medchemexpress, HY-B0274 50mg Chlorprothixene CAS:113-59-7 Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Ibuprofen-d3 | 121662-14-4 | MFCD06658737 | 99.9% | 209.30 | C13H15D3O2 | 10 MG
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Ibuprofen-d3 is the deuterium-labeled form of ibuprofen used as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS. It is supplied as a white to off-white solid and retains ibuprofen's COX-1 and COX-2 inhibitory profile, making it suitable for analytical and research applications.
- Deuterium-labeled internal standard for mass spectrometry and NMR.
- High purity (≈99.9%) for reliable quantitation.
- Soluble in DMSO up to 100 mg/mL with ultrasonic assistance.
- Stable when stored protected from light at recommended temperatures.
- Available in small analytical sizes suitable for standards and assays.
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