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Four distinct genes encoding closely related FGF receptors FGF R1 - 4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid-box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains referred to as the alpha isoform or only IgII and IgIII referred to as the beta isoform
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Four distinct genes encoding closely related FGF receptors FGF R1 - 4 are known All four genes for FGF Rs encode proteins with an N-terminal signal peptide three immunoglobulin (Ig)-like domains an acid-box region containing a run of acidic residues between the IgI and IgII domains a transmembrane domain and the split tyrosine-kinase domain Multiple forms of FGF R1 - 3 are generated by alternative splicing of the mRNAs A frequent splicing event involving FGF R1 and 2 results in receptors containing all three Ig domains referred to as the alpha isoform or only IgII and IgIII referred to as the beta isoform
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Fibroblast growth factor receptor 4(FGFR4) also known as CD334 (cluster of differentiation 334) is a member of the fibroblast growth factor receptor family where amino acid sequence is highly conserved between members and throughout evolution A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation
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The R-PLEX Human FGF BP1 Assay is a multiplex immunoassay kit from Meso Scale Diagnostics that allows for the simultaneous quantitative measurement of human FGF Basic Protein 1 in cell and tissue lysates serum plasma (EDTA) saliva and urine It utilizes electrochemiluminescence (ECL) detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements This assay kit includes a 96-well plate coated with capture antibodies detection antibodies labeled with an ECL compound calibrators controls 10X diluent and wash buffer It can accurately quantify FGF BP1 levels between 0 61 - 10 000 pg/mL with an incubation time of 2 hours
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Methoprene acid is an analog of the insect growth regulator, juvenile hormone. It binds directly to RXR and is a transcriptional activator in both insect and mammalian cells. It is RXR specific and does not activate the RAR pathway. Purity: ≥98% (TLC). Solubility: Soluble in DMSO or methanol. Long Term Storage: -20°C.
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Recombinant extracellular domain of canine CD40 expressed in HEK293 cells with a C-terminal His tag. Supplied lyophilized for research use in receptor-ligand interaction, signaling assays, and antibody binding studies.
Recombinant extracellular domain E21-A194 expressed in HEK293 cells.
C-terminal His tag for detection and purification.
Purity greater than 95% as determined by reducing SDS-PAGE.
Approximate molecular weight 30-40 kDa.
Supplied lyophilized with stabilizers and available as a 100 μg aliquot.
Suitable for receptor-ligand interaction, antibody binding, and signaling assays.
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Recombinant human guanylate-binding protein 1 (GBP1) expressed in HEK293 cells and supplied as a C-terminal His-tagged protein in PBS. GBP1 is a large GTPase involved in innate immunity, inflammasome regulation, and antiviral responses; this high-purity preparation is suitable for biochemical and cell-based assays.
Expressed in HEK293 cells
C-terminal 10xHis tag for detection and purification
Purity >95% by reducing SDS-PAGE
Approximate molecular weight 65 kDa
Supplied in 0.22 μm filtered PBS, pH 7.4
Shipped on dry ice; recommended storage at -80°C
Available in small packs down to 2 μg for assay optimization
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IgE is an important component of the immunoglobulin chain that coordinates humoral immunity As a receptor membrane-bound IgE initiates clonal expansion and B cell differentiation IgE Protein Mouse (HEK293 His) is the recombinant mouse-derived IgE protein expressed by HEK293 with C-His C-6 His labeled tag
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