General Cell Lines and Cell Cultures
Biochain Institute Inc Frozen Tissue Array - Rabbit Male Adult Normal Tissue, Multi-tissue I, 5 slides/PK
BioChain's rabbit normal multiple frozen tissue arrays are designed for studying tissue specific cellular localization of genes or proteins of interest in different rabbit tissues. Up to 30 different frozen tissues from the same male or female rabbit are mounted on positively charged glass slides. Total RNA and cDNA from those tissues may also be available upon request.
Eurofins Discoverx PathHunter TBXA2R Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0918C3)
The PathHunter TBXA2R Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of TBXA2R via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged TBXA2R. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting TBXA2R-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 rCHRM4 β-Arrestin Cell Line, 2 vials. (93-0870C2)
The PathHunter rCHRM4 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. acetylcholine) based activation of rCHRM4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rCHRM4 and EA-tagged β-Arrestin-2. Activation of rCHRM4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS CSF2RB/CSF2RA Dimerization Cell Line, 2 vials. (93-1078C3)
The PathHunter CSF2RB/CSF2RA Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GM-CSF) induced dimerization of CSF2RB/CSF2RA receptors. This product uses EFC technology. The cell line included overexpresses CSF2RB target protein fused to PK alongside CSF2RA target protein fused to EA. Upon ligand-induced dimerization of CSF2RB/CSF2RA, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx cAMP Hunter CHO-K1 HRH3 Gi Cell Line, 2 vials. (95-0103C2)
The cAMP Hunter HRH3 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. histamine) based activation of HRH3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type HRH3, a naturally Gi/Go coupled GPCR. Upon activation of HRH3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC MP46; Uveal Melanoma; Human (Homo sapiens)
MP46 is an epithelial-like cell line that was isolated in 2006 from the primary tumor in the uveal of a 69-year-old, male patient with melanoma. This cell line was deposited by F Nemati, Institute Curie.
Eurofins Discoverx PathHunter U2OS ACVRL1/ACVR2B Dimerization Cell Line, 2 vials. (93-0964C3)
The PathHunter ACVRL1/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVRL1 target protein fused to PK alongside ACVR2B target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/ACVR2B, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter CHO-K1 MRGPRX1 β-Arrestin Cell Line, 2 vials. (93-0919C2)
The PathHunter MRGPRX1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. BAM) based activation of MRGPRX1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged MRGPRX1 and EA-tagged β-Arrestin-2. Activation of MRGPRX1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx Ready-to-Assay NK3 Tachykinin Receptor Frozen Cells, 2 Vials of Cells. (HTS190RTA)
The Ready-to-Assay NK3 Tachykinin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. tachykinins) based activation of TACR3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TACR3 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of TACR3, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen OXGR1 α-Ketoglutarate Receptor Stable Cell Line, 2 vials. (HTS191C)
The ChemiScreen OXGR1 α-Ketoglutarate Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. α-ketoglutarate) based activation of OXGR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OXGR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OXGR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen M1 Acetylcholine Muscarinic Receptor Stable Cell Line, 2 vials. (HTS044C)
The ChemiScreen M1 Acetylcholine Muscarinic Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. acetylcholine) based activation of CHRM1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CHRM1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CHRM1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CGRP1 Calcitonin Receptor-Like Receptor Stable Cell Line, 2 vials. (HTS172C)
The ChemiScreen CGRP1 Calcitonin Receptor-Like Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. calcitonin) based activation of CALCRL - RAMP1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CALCRL alongside RAMP1 modifying protein and endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CALCRL, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ACROBiosystems HEK293/Human Transferrin R Stable Cell Line
CD antigen CD71 is also known as Transferrin receptor protein 1, TfR, sTfR, p90, TfR1, Trfr, which belongs to the peptidase M28 family and M28B subfamily. CD71 /TFR contains one PA (protease associated) domain. CD71 / TfR1 is required for iron delivery from transferrin to cells. CD71 is a potential new target in cases of human leukomia & lymphoma. CD71 /TFRC / TfR has been shown to interact with GABARAP and HFE.
Enzo Life Sciences LEADING LIGHT Wnt Cell Line Assay Reagents (1 Pack)
For use with the LEADING LIGHT. .The assay has been used successfully in different assay formats (including HTS applications) to identify several distinct categories of small molecule compounds that modulate the Wnt signaling pathway.The LEADING LIGHT.Note: the complete LEADING LIGHT Wnt Reporter Assay Starter Kit (Prod. No. ENZ-61001) is available. Alternative name: Wnt reporter reagents. Shipping: Shipped on Dry Ice. Long Term Storage: -80°C
iQ Biosciences Purified Human CD8 T Cells, 10M cells/vial
High-quality, high-viability (> 90%) human CD8 T cells are purified from PBMCs of healthy blood donors sourced from a world-renowned blood center. Highly enriched (typically > 90%) post-selection purity achieved via magnetic isolation. All orders come with an iQ Certificate of Analysis.