General Cell Lines and Cell Cultures
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Heart: Aorta Valve, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx cAMP Hunter CHO-K1 GPR84 Gi Cell Line, 2 vials. (95-0158C2)
The cAMP Hunter GPR84 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. embelin) based activation of GPR84 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GPR84, a naturally Gi/Go coupled GPCR. Upon activation of GPR84, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS EpoR/EpoR Dimerization Cell Line, 2 vials. (93-0965C3)
The PathHunter EpoR/EpoR Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. erythropoietin) induced dimerization of EpoR/EpoR receptors. This product uses EFC technology. The cell line included overexpresses EpoR target protein fused to PK alongside EpoR target protein fused to EA. Upon ligand-induced dimerization of EpoR/EpoR, detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/interleukins.
Invivogen Raji-hPD-1 Cells, Human Lymphoblast-Like Cells, Target Cells for ADCC Assays, 3-7 x 10^6 cells
Raji-hPD-1 cells are engineered human lymphoblast-like cells designed for in vitro assays, especially antibody-dependent cellular cytotoxicity (ADCC) studies. They feature stable overexpression of human PD-1, verified by flow cytometry. These cells serve as target cells for ADCC and CAR-T cell toxicity assays, supporting functional immune checkpoint research. Their guaranteed mycoplasma-free status and high passage stability make them reliable for experiments.
ATCC Genomic DNA from; Cowpox virus; Strain Brighton Red
Genomic DNA isolated from a preparation of Cowpox virus strain Brighton (ATCC VR-302). This product can be used for PCR and other molecular biology applications.
Vector Biolabs codon-optimized FLP (FLPo) and eGFP Adenovirus (Ad-GFP-FLPo)
FLP from Saccharomyces cerevisiae, a site-specific recombinases (SSR) from the λ integrase family, recognizes distinct 34 bp FRT sites. It has been widely used for generating conditional knockout mice, mediated by FLP/FRT system. Initial use of FLP in mammalian cells revealed inefficient recombinase activity due to thermo-instability of the FLP protein. Subsequent screening for thermo-stable mutants resulted in the identification of FLPe, with a 4-fold increase in recombination efficiency at 37C. However the recombination efficiency of FLPe in cells remains very low because of its non-mammalian origin. This mouse codon optimized FLPe greatly increase the recombination efficiency in mouse cells.This adenovirus express a mouse codon-optimized FLP recombinase (FLPo), along with an eGFP marker. FLPo and eGFP are driven by the same CMV promoter and separated by a 2A peptide.
Biolegend Veri-Cells™ Activated (Cytokine) PBMC
Veri-Cells™ Activated (Cytokine) PBMC Apps: FC; Size: 50 tests
ATCC Quantitative Genomic DNA from; Staphylococcus saprophyticus; subsp. saprophyticus
Quantitative genomic DNA from Staphylococcus saprophyticus subsp. saprophyticus strain NCTC 7292 (ATCC 15305) can be used for assay development, verification, and validation as well as monitoring day-to-day test variation and the lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
Eurofins Discoverx PathHunter CHO-K1 NPY1R β-Arrestin Cell Line, 2 vials. (93-0397C2)
The PathHunter NPY1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged NPY1R and EA-tagged β-Arrestin-2. Activation of NPY1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS mFCGR2B Clustering Cell Line, 2 vials. (93-1139C3)
The Path Hunter mFcyRIIb clustering cell line is a stable, engineered cell line designed to increase signal produced from a Checkpoint Cell Line via antibody-mediated crosslinking of the receptors. This product is a companion product used to determine cross-linking based increases in potency of agonist antibodies. The cell line included overexpresses mFcyRIIb Fcg receptor. When co-cultured with a Checkpoint Cell Line in the presence of agonist antibody, the Fcg receptor binds to the antibody, inducing receptor clustering. The induced receptor clustering leads to increased activation and downstream signaling, leading to increased EFC signal production. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
ACROBiosystems Human Mesothelin 2Vials
Mesothelin (MSLN) is also known as CAK1 antigen Pre-pro-megakaryocyte-potentiating factor which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.
ATCC SU-DHL-6; Large Cell Lymphoma; Human (Homo sapiens)
SU-DHL-6 is a lymphoblast-like cell that was isolated from the peritoneal effusion of a White, 43-year-old, male patient with large cell lymphoma. This cell line was deposited by A Epstein in 1977.
Eurofins Discoverx ChemiScreen EP4 Prostanoid Receptor Membrane Preparation, 1 vial. (HTS142M)
The ChemiScreen EP4 Prostanoid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of PTGER4 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
ATCC Streptococcus pneumoniae; s. africa 19a-7
Intermediate resistance to penicillin. Representative strain of the Pneumococcal Molecular Epidemiology Network (PMEN).
Eurofins Discoverx ChemiBrite FP Prostanoid Receptor Stable Cell Line, 2 vials. (HTS093L)
The ChemiBrite FP Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin F2a) based activation of PTGFR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGFR, a naturally Gq coupled GPCR. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGFR, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.