General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen SST2 Somatostatin Receptor Membrane Preparation, 1 vial. (HTS028M)
The ChemiScreen SST2 Somatostatin Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of SSTR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay SST2 Somatostatin Receptor Frozen Cells, 2 Vials of Cells. (HTS028RTA)
The Ready-to-Assay SST2 Somatostatin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen PTH1 Parathyroid Hormone Receptor Stable Cell Line, 2 vials. (HTS030C)
The ChemiScreen PTH1 Parathyroid Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. parathyroid hormone) based activation of PTH1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTH1R alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PTH1R, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CRTH2/DP2 Prostanoid Receptor Membrane Preparation, 1 vial. (HTS031M)
The ChemiScreen CRTH2/DP2 Prostanoid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of PTGDR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach or to screen for GPCR activity using GTPγS assays. Increased binding affinities or GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay GPR54/KiSS1 Receptor Frozen Cells, 2 Vials of Cells. (HTS032RTA)
The Ready-to-Assay GPR54/KiSS1 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand based activation of KISS1R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses KISS1R alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of KISS1R, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen GPR14 Urotensin II Receptor Membrane Preparation, 1 vial. (HTS033M)
The ChemiScreen GPR14 Urotensin II Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of UTS2R surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen NTR1 Neurotensin Receptor Stable Cell Line, 2 vials. (HTS034C)
The ChemiScreen NTR1 Neurotensin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neurotensin) based activation of NTSR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NTSR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of NTSR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay NTR1 Neurotensin Receptor Frozen Cells, 2 Vials of Cells. (HTS034RTA)
The Ready-to-Assay NTR1 Neurotensin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. neurotensin) based activation of NTSR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NTSR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of NTSR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen CCR9 Chemokine Receptor Stable Cell Line, 2 vials. (HTS036C)
The ChemiScreen CCR9 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL25/TECK) based activation of CCR9 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR9 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR9, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen CCR9 Chemokine Receptor Membrane Preparation, 1 vial. (HTS036M)
The ChemiScreen CCR9 Chemokine Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of CCR9 surface expression. ChemiScreen membrane preps can be used to screen for GPCR activity using GTPγS assays. Increased GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx ChemiScreen PAR2 Receptor Stable Cell Line, 2 vials. (HTS037C)
The ChemiScreen PAR2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAR2) based activation of F2RL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses F2RL1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of F2RL1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen PAR2 Receptor Membrane Preparation, 1 vial. (HTS037M)
The ChemiScreen PAR2 Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of F2RL1 surface expression. ChemiScreen membrane preps can be used to screen for GPCR activity using GTPγS assays. Increased GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Revvity Health Sciences Inc Tag-lite Serotonin 5HT-4 Receptor Frozen & Labeled Cells, 200 Assay Points
Tag-lite Serotonin 5HT-4 Receptor Frozen & Labeled Cells, 200 Assay Points
Revvity Health Sciences Inc Tag-lite Adrenergic β2 Receptor Frozen & Labeled Cells, 200 Assay Points
Tag-lite Adrenergic β2 Receptor Frozen & Labeled Cells, 200 Assay Points
Revvity Health Sciences Inc Tag-lite δ-Opioid Receptor (OP1) Frozen & Labeled Cells, 200 Assay Points
Tag-lite δ-Opioid Receptor (OP1) Frozen & Labeled Cells, 200 Assay Points