General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen NOP/ORL1 Opioid Receptor Stable Cell Line, 2 vials. (HTS040C)
The ChemiScreen NOP/ORL1 Opioid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orphanin FQ) based activation of OPRL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRL1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of OPRL1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay V2 Vasopressin Receptor Frozen Cells, 2 Vials of Cells. (HTS060RTA)
The Ready-to-Assay V2 Vasopressin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. vasopressin) based activation of AVPR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AVPR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of AVPR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx cAMP Hunter CHO-K1 CXCR5 Gi Cell Line, 2 vials. (95-0082C2)
The cAMP Hunter CXCR5 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL13/BCA-1/BLC) based activation of CXCR5 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CXCR5, a naturally Gi/Go coupled GPCR. Upon activation of CXCR5, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 FFAR3 (GPR41) Gi Cell Line, 2 vials. (95-0136C2)
The cAMP Hunter FFAR3 (GPR41) Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. FFAs) based activation of FFAR3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type FFAR3, a naturally Gi/Go coupled GPCR. Upon activation of FFAR3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Amsbio LLC STAT3 Leeporter™ Luciferase Reporter-Ba/F3 Cell Line
STAT3 Leeporter™ Luciferase Reporter-Ba/F3 Cell Line
Eurofins Discoverx PathHunter CHO-K1 HRH1 β-Arrestin Cell Line, 2 vials. (93-0503C2)
The PathHunter HRH1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. histamine) based activation of HRH1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged HRH1 and EA-tagged β-Arrestin-2. Activation of HRH1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 ADRA2C Gi Cell Line, 2 vials. (95-0053C2)
The cAMP Hunter ADRA2C Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. epinephrine and norepinephrine) based activation of ADRA2C GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADRA2C, a naturally Gi/Go coupled GPCR. Upon activation of ADRA2C, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 RXFP1 Gs Cell Line, 2 vials. (95-0127C2)
The cAMP Hunter RXFP1 (LGR7) Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. relaxin-2) based activation of RXFP1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type RXFP1, a naturally Gs coupled GPCR. Upon activation of RXFP1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Betacoronavirus 1 RNA; Strain: OC43; Human coronavirus OC43
Genomic RNA isolated from a preparation of cell lysate and supernatant from HCT-8 cells (ATCC CCL-244) infected with Betacoronavirus 1 strain OC43 (ATCC VR-1558).This product was prepared using methods known to inactivate viruses. It is suitable for use in RT-PCR or other RNA-based procedures. The source organism and host cells are also available through the ATCC catalog.
Eurofins Discoverx Ready-to-Assay GPR120 Receptor Frozen Cells, 2 Vials of Cells. (HTS225LRTA)
The Ready-to-Assay GPR120 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. free fatty acids) based activation of FFAR4 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses FFAR4 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of FFAR4, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Lonza Walkersville Rat Brain Striatum Astrocytes
Ready-to-use Clonetics Rat Brain Striatum Astrocytes are obtained from rat brain passaged once and prepared as cell suspensions for shipment on dry ice Each vial contains approximately 1 million cells Astrocytes can be easily thawed and cultured Astrocytes can be harvested and re-plated or stored frozen for later use The cells are shipped overnight on dry ice Recommended medium AGM BulletKit (CC-3186)
![ATCC Quantitative Genomic DNA from; Enterococcus faecalis; Strain: [Portland]](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502381735.PNG-250.jpg)
ATCC Quantitative Genomic DNA from; Enterococcus faecalis; Strain: [Portland]
Quantitative Genomic DNA from Enterococcus faecalis can be used for assay development, verification, validation, monitoring of day-to-day test variation, and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine bacterial load.
iXCells Biotechnologies Human Peripheral Blood CD19 B
Human Peripheral Blood CD19+ B Cells (Untouched)
iXCells Biotechnologies Human Cardiac Microvascular En
Human Cardiac Microvascular Endothelial Cells (HCMEC)