General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter HCRTR1 Total GPCR Internalization U2OS Cell Line, 2 vials. (93-0729C3)
The PathHunter HCRTR1 Total GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of HCRTR1 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged HCRTR1 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the HCRTR1 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 mCXCR3 β-Arrestin Cell Line, 2 vials. (93-0553C2)
The PathHunter mCXCR3 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL11/I-TAC) based activation of mCXCR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged mCXCR3 and EA-tagged β-Arrestin-2. Activation of mCXCR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC Fusarium keratoplasticum; genomic DNA
Genomic DNA isolated from Fusarium keratoplasticum FIV/74. This fungal strain is also available as ATCC Catalog No.: 36031™.
Eurofins Discoverx ChemiScreen SST2 Somatostatin Receptor Stable Cell Line, 2 vials. (HTS028C)
The ChemiScreen SST2 Somatostatin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SSTR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SSTR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx PathHunter U2OS ACVR1B/BMPR2 Dimerization Cell Line, 2 vials. (93-1072C3)
The PathHunter ACVR1B/BMPR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. activin A) induced dimerization of ACVR1B/BMPR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR1B target protein fused to PK alongside BMPR2 target protein fused to EA. Upon ligand-induced dimerization of ACVR1B/BMPR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Vector Biolabs human CDK9 shRNA Adenovirus (Ad-h-CDK9-shRNA)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
Biochain Institute Inc Paraffin Tissue Section - Parkinson's Disease: Brain: Hippocampus, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx InCELL Hunter A549 HCK Kinase Binding Cell Line, 2 vials. (96-0041C15)
The InCELL Hunter A549 HCK Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of HCK via detection of HCK levels. This product uses EFC technology. The cell line included overexpresses HCK target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Biochain Institute Inc Paraffin Tissue Section - Human Colon Tumor: Adenocarcinoma (Ulcer), 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Salmonella enterica; subsp. enterica; genomic DNA
Genomic DNA isolated from Salmonella enterica subsp. enterica serovar Infantis strain MZ1479. This bacterial strain is also available as ATCC Catalog No. BAA-1675™.
ATCC Lactobacillus plantarum; Strain: IDCC 3502
Lactobacillus plantarum strain IDCC 3502 was isolated from homemade kimchi in South Korea.
ATCC Corynebacterium diphtheriae; genomic DNA
Genomic DNA isolated from Corynebacterium diphtheriae. This bacterial strain is also available as ATCC Catalog No. 700971™.
ATCC Quantitative Synthetic; Powassan virus; lineage II RNA
Quantitative synthetic Powassan virus lineage II RNA can be used for assay development, verification, and validation as well as monitoring of day-to-day test variation and lot-to-lot performance of molecular-based assays. The quantitative format allows for the generation of a standard curve for quantitative PCR (qPCR) to determine viral load. This preparation includes fragments from the E, NS1, NS5, and 3’ UTR regions.