General Cell Lines and Cell Cultures
Eurofins Discoverx ChemiScreen AT1 Angiotesin Receptor Stable Cell Line, 2 vials. (HTS064C)
The ChemiScreen AT1 Angiotensin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. Angiotensin-II) based activation of AGTR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses AGTR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of AGTR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen PAR2 Receptor Stable Cell Line, 2 vials. (HTS037C)
The ChemiScreen PAR2 Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAR2) based activation of F2RL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses F2RL1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of F2RL1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx RBL-2H3 ADORA2A Gq Cell Line, 2 vials. (95-1008C11)
The ADORA2A Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. adenosine, NECA) based activation of ADORA2A GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses ADORA2A, a naturally Gq coupled GPCR. Upon activation of ADORA2A, the resulting calcium activity can be fluorescently assayed using the Calcium No WashPLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx Ready-to-Assay MRGPRX2 Receptor Frozen Cells, 2 Vials of Cells. (HTS058RTA)
The Ready-to-Assay MRGPRX2 Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. cortistatin-14, PAMP) based activation of MRGPRX2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MRGPRX2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of MRGPRX2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Biochain Institute Inc Frozen Tissue Section - Parkinson's Disease: Brain, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Cell Applications Inc Proliferating Dermal Microvascular Endothelial Cells (CADMEC), Pre-Screened, Neonatal
Proliferating Dermal Microvascular Endothelial Cells (CADMEC), Pre-Screened, Neonatal
ATCC Geobacillus stearothermophilus N
This strain is recommended by ATCC for use in the tests described in AOAC Official Methods 982.15, 982.18, and 988.08 where only the taxon is specified. Used in the assay of beta-lactam antibiotics.
ATCC HCT116-SLC15A4-KO-c10; Colorectal carcinoma; Human (Homo sapiens)
The HCT116-SLC15A4-KO-c10 cell line contains a -7 deletion in SLC15A4 gene and combined with the parental cell line and other HCT116 derivatives can be used in cancer drug screening.
Cell Applications Inc Human Coronary Artery Endothelial Cells, with Asthma Total Kit
Human Coronary Artery Endothelial Cells, with Asthma Total Kit(300AS-05a) Cryopreserved (HCAEC-AS),1 vial, adult(212-500) MesoEndo Cell Growth Media 500ml(090K) Subculture Reagent Kit
Cell Applications Inc Proliferating Bovine Pulmonary Artery Smooth Muscle Cells (BPASMC)
Proliferating Bovine Pulmonary Artery Smooth Muscle Cells (BPASMC)
STEMCELL Technologies Plerixafor Mobilized Human Peripheral Blood Mononuclear Cells, Frozen, Size: 1 x 10^8 cells
Start your assays with ready-to-use, ethically sourced, mobilized primary mononuclear cells. We help you get the cells you need with personalized service, custom products, flexible delivery times, and the option to reserve entire lots to prescreen cells for applications. Donors are mobilized with G-CSF, plerixafor, or G-CSF and plerixafor prior to collection. Isolated from leukapheresis samples using density gradient separation or red blood cell lysis and cryopreserved in CryoStorCS10 medium, cells are obtained using Institutional Review Board (IRB)-approved consent forms and protocols. Additional documentation and high-resolution HLA typing (Class I and Class II alleles and CMV status) are available upon request. ACDA is added as an anticoagulant. Contact techsupport@stemcell.com for donor specifications (BMI category, smoking status, ethnicity, etc.). Donors are screened for HIV-1, HIV-2, hepatitis B, and hepatitis C. Certain products are only available in select territories.
Cell Applications Inc Proliferating Corneal Epithelial Cells (HCEpC), Adult
Proliferating Corneal Epithelial Cells (HCEpC), Adult
ATCC HCM-CSHL-0090-C25; Cancer Model Primary; Pancreatic Ductal Adenocarcinoma; Human (Homo sapiens)
A patient-derived next-generation cancer model generated by the Human Cancer Models Initiative (HCMI). HCM-CSHL-0317-C18 (ATCC No. PDM-359) was isolated from primary cancer of colon tissue. This tumor-derived model can be used in basic research and pharmacological screening applications. Data for the parental tumor and the tumor-derived organoid models are available at the GDC. Additional molecular characterizations may be available at the GDC. Additional controlled data may be available via dbGaP.
Cayman Chemical OrexIn A17-33humnmous 1mg
A peptide orexin receptor 1 agonist; selectively induces calcium mobilization in CHO cells overexpressing human OX1R over CHO cells overexpressing human OX2R (EC50s = 8.29 and 187 nM, respectively)