General Cell Lines and Cell Cultures
ATCC Cladosporium cladosporioides
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
ATCC Pen-Strep, 100X
This solution contains 10,000 I.U./mL Penicillin, 10,000 (μg/mL) Streptomycin. It is used for reducing the chances of microbial contamination in cell culture. Between 0.5 and 1 mL of Penicillin-Streptomycin solution are added to 100 mL of cell culture media for a final concentration of 50 to 100 I.U./mL penicillin and 50 to 100 (μg/mL) streptomycin. This product has applications for cell culture, cell growth, and viability.
Eurofins Discoverx PathHunter CHO-K1 GPR149 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0420C2A)
The PathHunter GPR149 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR149 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR149 and EA-tagged β-Arrestin-2. Activation of GPR149 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter PTAFR Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0680C3)
The PathHunter PTAFR Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of PTAFR via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged PTAFR. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting PTAFR-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 CCRL2 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0333C2A)
The PathHunter CCRL2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL19) based activation of CCRL2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCRL2 and EA-tagged β-Arrestin-2. Activation of CCRL2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 GCGR β-Arrestin Cell Line, 2 vials. (93-0241C2)
The PathHunter GCGR cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. glucagon) based activation of GCGR GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GCGR and EA-tagged β-Arrestin-2. Activation of GCGR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter NPY2R Activated GPCR Internalization U2OS Cell Line, 2 vials. (93-0721C3)
The PathHunter NPY2R Activated GPCR internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of NPY2R via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged NPY2R. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting NPY2R-arrestin complex is internalized to the early endosome, leading to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 TACR3 β-Arrestin Cell Line, 2 vials. (93-0501C2)
The PathHunter TACR3 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. substance P, senkitide) based activation of TACR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged TACR3 and EA-tagged β-Arrestin-2. Activation of TACR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 GPR35 β-Arrestin Cell Line, 2 vials. (93-0942C2)
The PathHunter GPR35 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. zaprinast) based activation of GPR35 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR35 and EA-tagged β-Arrestin-2. Activation of GPR35 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
ATCC MA-10; Leydig Cell Tumor; Mouse (Mus musculus)
MA-10 is a cell line derived from the testis of a transplantable Leydig cell tumor, M5480P, by alternately growing it in culture and in host animals. Cells obtained from culture-derived tumors were cloned. A clone, designated MA-10, was determined to have retained functional hCG receptors. These cells synthesize progesterone in response to human chorionic gonadotropin (hCG).
ATCC Purified; Influenza A virus (H1N1); A/PR/8/34
Influenza A virus (H1N1) strain A/PR/8/34 is a high-titer, purified, live virus that is propagated in SPF chicken embryonated eggs. This strain was isolated in 1934 from a human patient in Puerto Rico and was deposited by the Centers for Disease Control and Prevention. This product has applications in respiratory disease research, antiviral studies, assay development, and vaccine development.