General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 NPY1R β-Arrestin Cell Line, 2 vials. (93-0397C2)
The PathHunter NPY1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged NPY1R and EA-tagged β-Arrestin-2. Activation of NPY1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Lung, 2x10 ug/PK
BioChain's human DNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of DNA prepared from primary tumor and its adjacent normal tissue; PM consists of DNA prepared from primary tumor and corresponding ponding metastatic tumor. Genomic DNA in each pair is prepared from the same donor. This product line is designed foridentifying tumor-specific genes and tumor metastatic genes.
Eurofins Discoverx PrecisION hCav3.2 Recombinant Stable Cell Line, 2 vials. (CYL3075)
The PrecisION hCav3.2 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Cav3.2 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Cav3.2 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
ATCC Salmonella enterica; subsp. enterica; serovar Bispebjerg
Bacteriophage host. Used as a control strain for the detection of Salmonella and in the examination of dairy products.
ATCC Pfizer Pneumococcal polysaccharide powder Type 5 (d5) 200mg
Purified pneumococcal polysaccharide type 5 is manufactured by Pfizer, Inc., for small-quantity distribution by ATCC. The pneumococcal powder type 5 (200 mg) is a component of the current 13-valent vaccine against Streptococcus pneumoniae. The pneumococcal polysaccharide type 5 can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
ATCC Rhizobium rhizogenes
Rhizobium rhizogenes strain [CIP 104786] is a whole-genome sequenced strain that produces isoprene. This bacterium has applications in agricultural research.
Eurofins Discoverx P2RY1 Gq Calcium Signaling Cell-Based Assay Kit (1321N1)
The P2RY1 Gq Stable Cell Line Calcium Signaling Assay (1321N1) contains a stable clonal cell line used to measure P2RY1 (GPCR) activity via an increase in intracellular calcium. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Brain: Medulla Oblongata, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx cAMP Hunter CHO-K1 OXER1 Gi Cell Line, 2 vials. (95-0089C2)
The cAMP Hunter OXER1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. 5-oxo-ETE) based activation of OXER1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type OXER1, a naturally Gi/Go coupled GPCR. Upon activation of OXER1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Paraffin Tissue Section - Human Gallbladder Tumor: Adenocarcinoma, Poorly Differentiated, 5 sides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from a single human tumor. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
ATCC Pfizer Pneumococcal polysaccharide powder Type 25 (d25F) 10mg
Purified pneumococcal polysaccharide type 25F is manufactured by Pfizer, Inc. for small quantity distribution by ATCC. The pneumococcal polysaccharide type 25F can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
ATCC Mesomycoplasma hyopneumoniae
This strain of Mesomycoplasma hyopneumoniae is a bacterial type strain with applications in respiratory disease research. This organism is grown on Revised Mycoplasma medium.
Eurofins Discoverx Ready-to-Assay GPBA Bile Acid Receptor Frozen Cells, 2 Vials of Cells. (HTS238LRTA)
The Ready-to-Assay GPBA Bile Acid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. lithocholic acid, other bile acids) based activation of GPBAR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses GPBAR1 alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of GPBAR1, the resulting calcium activity can be assayed in either detection mode. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx PathHunter P2RY12 Total Internalization U2OS Cell Line, 2 vials. (93-0952C3)
The PathHunter P2RY12 Total Internalization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This cell line uses EFC technology to measure ligand-induced internalization of P2RY12 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged P2RY12 and a ProLink-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the P2RY12 receptor to the early endosome leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter Rhesus TrkA-P75 Functional Kinase Cell-Based Assay Kit (U2OS)
The PathHunter Rhesus TrkA-P75 Stable Cell Line Functional Kinase Assay (U2OS) measures TrkA-P75 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.