General Cell Lines and Cell Cultures
ACROBiosystems HEK293/Human PD-1 Stable Cell Line
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IF
Cell Biologics PORCINE DERMAL FIBROBLASTS-NEO
PORCINE PRIMARY DERMAL FIBROBLASTS (NEONATAL) - Frozen Vial
Genscript Corporation CD47 hFc ChimeraBiotin Avi
CD47 (Cluster of Differentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRP ) CD-47 acts as a don t eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers
Expression Systems CHO-ES (suspension CHO K1) cells, Frozen in ESF SFM, 20M cells/vial
Expression Systems offers CHO mammalian cell lines adapted to serum-free suspension culture in ESF SFM. The availability of pre-adapted cells saves significant time and expense associated with the adaptation of cultures.
CHO-ES cells are derived from the CHO (Chinese Hamster Ovary) cell line. CHO-ES cells are adapted for suspension culture in ESF SFM and are available as a frozen vial.
• Capable of high levels of recombinant protein expression
• Good growth in adherent or suspension culture
• Quality and performance testing
Organism: Cricetulus griseus, hamster, Chinese
Tissue: Ovary
Cell Type: Epithelial
Biosafety Level 1: Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
To download Instructions for Use and/or COA please visit: www.expressionsystems.com