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Cayman Chemical VIlazodonhydrochlorIde 100mg
An SSRI and a partial agonist of 5-HT1A (IC50 s = 0.2 and 0.5 nM, respectively); increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex at 1 and 3 mg/kg, i.p.; decreases immobility in the forced swim test in both rats and mice at 1 mg/kg
Cayman Chemical N-PropIonylglycIn 100mg
A glycine-conjugated form of propionic acid; urinary levels are increased in patients with propionic acidemia
Cayman Chemical PImonIdazole 100mg
A small molecule radiosensitizer that has proven to be an effective and nontoxic immunochemical hypoxia marker for human squamous cell carcinomas of the cervix, head and neck
Cayman Chemical T16A Inh-A01 50mg
An aminophenylthiazole that inhibits transient TMEM16A-mediated chloride currents with an IC50 value of ~1 µM; blocks CaCC activity in vascular smooth muscle cells and relaxes mouse and human blood vessels
Cayman Chemical PDMPhydrochlorIde 50mg
A ceramide analog that contains a mixture of all four possible stereoisomers; inhibits glucosylceramide synthase by 90% when used at a concentration of 0.8 μM in MDCK cell homogenates and inhibits β-1,4-galactosyltransferase 6, however, the inhibitory activity on both enzymes is attributed to the D-threo enantiomer; enhances curcumin-induced inhibition of proliferation, JNK activation, and Akt inhibition, as well as induction of apoptosis in WM-115 melanoma cells in vitro
Cayman Chemical 2-trns-HexadecenoIc AcId 50mg
An intermediate formed in the β-oxidation of palmitic acid
Cayman Chemical PAPA Nonate 100mg
PAPA NONOate is a NO donor. It spontaneously dissociates in a pH-dependent, first-order process with a half-life of 15 minutes and 77 minutes at 37°C and 22-25°C, respectively, pH 7.4, to liberate 2 moles of NO per mole of parent compound.{1190,5437}
Cayman Chemical PRfluoropropnsulfonIc ACD 50mg
A perfluoroalkyl substance; has been found as a contaminant in groundwater in areas treated with aqueous film-forming foam fire extinguishing agents
Cayman Chemical INCB 3284dImesylate 50mg
A potent, selective, and orally bioavailable antagonist of MCP-1 binding to CCR2 (IC50 = 3.7 nM); inhibits chemotaxis in vitro (IC50 = 4.7 nM) and displays acceptable oral bioavailability in mice, rats, dogs, monkeys, and chimpanzees
Cayman Chemical N 4ACTAmIdophenylIndomet 50mg
N-4AIA is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.{8243} N-4AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.1 and 0.625 µM, respectively.{8243,8513} It is about 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.
Cayman Chemical PrazosInhydrochlorIde 50mg
An α1-AR antagonist; selectively binds to α1-ARs (Kis = 0.2, 0.25, and 0.32 nM for the human recombinant α1A-, α1B-, and α1D-ARs, respectively), over α2-ARs (Kis = 340 and 3.7 nM in α2A-AR-expressing HT-29 cells and α2B-AR-expressing NG108 cells, respectively); binds to MT3 in hamster brain membranes (IC50 = 7.8 nM); inhibits peripheral and central postsynaptic α1-ARs (IC50s = 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively); decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats at 1 mg/kg; increases the number of entries and percentage of time spent in the open arms of the elevated plus maze in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats at 1.5 mg/kg
Cayman Chemical CarbetocInacetate 50mg
A peptide oxytocin receptor agonist; binds to oxytocin receptors (Kd = 1.96 nM); selectively binds to oxytocin receptors over vasopressin V2 receptors (Kds = 1.96 and 61.3 nM, respectively); induces contraction of isolated rat uterine strips (EC50 = 48 nM); inhibits oxytocin-induced contraction of isolated rat uterine strips (pA2 = 8.21); increases the frequency and amplitude of uterine contractions in EArly postpartum dairy cows at 0.35 mg/animal; prevents stress-induced reinstatement of morphine-seeking behavior in mice at 6.4 mg/kg; reverses learned helplessness and decreases social withdrawal induced by chronic unpredictable stress in tree shrews
Cayman Chemical PropIverInhydrochlorIde 50mg
A muscarinic acetylcholine receptor antagonist; binds to M1 and M2 mAChRs in rat bladder and submaxillary gland, respectively (Kis = 0.3 and 0.19 µM, respectively); inhibits carbachol-induced contraction of bladder strips isolated from patients with normal bladder activity and detrusor overactivity associated with benign prostatic hyperplasia (pA2s = 7.7 and 7.6, respectively)
Cayman Chemical MemntInhydrochlorIde 100mg
An NMDA receptor antagonist; blocks NMDA-induced currents in rat retinal ganglion cells by 90% at 12 μM; reverses I1PP2A-induced inhibition of dephosphorylation of tau194-207 in vitro; restores PP2A activity, decreases GSK-3β and Aβ levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory in the AAV1-I1PP2A rat model of Alzheimer's disease at 2 mg/kg; reduces responding on the ethanol-associated lever in a cue-induced ethanol seeking test in rats at 20 mg/kg; decreases secretion of MMP-9, degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia