Sera
Cayman Chemical UDPD-GlucosesodIum salt 100mg
A nucleotide sugar and P2Y14 receptor agonist; induces inositol phosphate production in COS-7 cells expressing the human P2Y14 receptor (EC50 = 0.588 µM)
Cayman Chemical 3-MethoxytyrosIn 50mg
An active metabolite of L-DOPA; inhibits L-DOPA-induced neuroprotection in rat primary mesencephalic dopaminergic neurons at 10 and 100 µM
Cayman Chemical BMK methyl glycIdate 50mg
An analytical reference standard categorized as a precursor in the synthesis of phenylacetone; intended for research and forensic applications
Cayman Chemical MPPodde 100mg
An active metabolite of MPTP, a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism; inhibits complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress
Cayman Chemical LactosylceramIdebovIn but 50mg
A mixture of LacCers isolated from bovine buttermilk with variable N-acyl chain lengths; expressed on the plasma membrane of human phagocytes; mediates phagocytosis, chemotaxis, and superoxide generation; forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors; elevated levels in kidney cortex homogenates and urine are directly correlated with hyperglycemia, insulin resistance, and obesity in db/db transgenic diabetic mice; promotes recruitment of CNS-infiltrating monocytes and microglia, and enhances neurodegeneration in mice with chronic EAE, a model of MS; correlated with increased levels of pro-inflammatory cytokines IL-6, MCP-1, and MIP-1β, as well as lipids and macrophages in atherosclerotic plaques
Cayman Chemical IbndronatesodIum hydrate 50mg
A bisphosphonate that has been used in formulations for the treatment of osteoporosis; inhibits bone resorption
Cayman Chemical CarfIlzomIb 50mg
An irreversible inhibitor of the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases; induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM)
Cayman Chemical NordeoxycholIc AcId 100mg
A metabolite of norcholic acid and derivative of deoxycholic acid; hepatic levels are decreased in rats in a high-fat diet model of NAFLD; serum levels are lower in men compared with women; has commonly been used as an internal standard for the quantification of bile acids in various sample types by GC- and LC-MS
Cayman Chemical AcepromazInmaleate 100mg
A phenothiazine antipsychotic and a dopamine receptor antagonist; binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits acetylcholine-induceed contractions of guinea pig ileum (IC50 = 840 nM); inhibits morphine-induced vomiting in dogs; inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively)
Cayman Chemical PInoresInol DIglucosIde 50mg
A lignan with diverse biological activities; inhibits peroxidation of a linoleic acid emulsion by 64.2% at 20 μg/ml, scavenges hydrogen peroxide and DPPH, ABTS, and superoxide anion free radicals, and has ferrous ion metal chelating activity in cell-free assays; inhibits increases in serum levels of inorganic phosphate, IL-6, and TNF-α and decreases in serum calcium levels and transverse diameter, weight, bone mineral content, and bone mineral density of the right femur in a rat model of osteoporosis induced by dexamethasone at 10, 20, and 40 mg/kg
Cayman Chemical BenznIdazole 100mg
An orally bioavailable antiprotozoal agent; inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively); inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions at 100 μM; decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease at 100 mg/kg per day
Innovative Research Inc Human Immunoglobulin G (IgG) Depleted Serum 100ml
Immunoglobulin G (IgG) Depleted Human Serum from Innovative Research is prepared from high-quality human serum using immobilized Protein A.
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 50mg
A phospholipid; a major component of E. coli bilayers; vesicles composed of 1,2,-POPE can be disrupted by polycationic antimicrobials; has been used in combination with other lipids in the formation of LNPs for spleen- and liver-specific targeting in mice
Cayman Chemical DLRythroPDMPhydroCLOrId 100mg
A PDMP mixture containing D-erythro (1S,2R) PDMP and L-erythro (1R,2S) PDMP; protects GlcCer synthase from degradation and increases ceramide levels in MDCK cells at 40 µM; inhibits UDP galactose:ceramide galactosyltransferase by 27% in mouse brain microsomes at 100 µM; inhibits the growth of isolated rabbit skin fibroblasts at 50 µM but is cytotoxic at >50 µM
Cayman Chemical E-5- 2-BromovInyluracIl 50mg
A pyrimidine base; is an inactive metabolite of the antiviral agents sorivudine and BVDU that may be regenerated to BVDU in vivo; irreversibly inactivates DPD in an NADPH-dependent manner; enhances the efficacy of the chemotherapeutic agent and DPD substrate 5-FU in a P388 murine leukemia model at 200 µmol/kg, increasing survival time