Sera
Cayman Chemical GnglIosIde GM1porcInam 50mg
A mixture of ganglioside GM1; interacts with other proteins to increase calcium influx, affecting various calcium-dependent processes, including inducing neuronal outgrowth during differentiation; acts as a receptor for cholera toxin and the heat-labile enterotoxin from E. coli; induces apoptosis in activated T cells; found at higher levels on T cells isolated from patients with RCC; levels are decreased in the substantia nigra pars compacta in postmortem brain from patients with Parkinson’s disease accumulates in neurons in ganglioside GM1 gangliosidosis
Cayman Chemical ThonzonIumbromIde 100mg
A quaternary ammonium-containing cationic surfactant with diverse biological activities; an inhibitor of F. tularensis AcpB (Ki = 0.59 µM) and C. albicans V-ATPase (EC50 = 69 µM); inhibits osteoclastogenesis RANKL-induced osteoclastogenesis in BMDMs; inhibits bone resorption by mature osteoclasts at 100 and 200 nM; prevents LPS-induced bone loss in a calvarial osteolytic mouse model at 5 mg/kg per day; induces mortality in C. oncophora, O. ostertagi, H. contortus, and T. circumcincta (EC50s = 4.5, 10.8, 5.1, and 6.7 µM, respectively) but is cytotoxic to HEK293 and RAW 264.7 cells (CC50s = 9.2 and 5.7 µM, respectively)
Cayman Chemical MethsuxImIde 100mg
An anticonvulsant; inhibits CYP2C19-mediated metabolism of chlorproguanil and proguanil at 100 µM; protects against leptazol-induced convulsions in rats when administered at a dose of 100 mg/kg
Sigma Aldrich Fine Chemicals Biosciences Bovine Calf Serum USA orig
Animal serum is commonly used to supplement basal media formulations for the optimal growth of many cell types in vitro. Bovine Calf Serum (BCS) is collected from calves that are less than 12 months old. The serum contains approximately double the protein of fetal bovine serum (fBS). BCS will promote growth in a variety of mammalian cell lines and is often used as a cost-effective substitute for fBS.
Cayman Chemical Buparvaquon 50mg
An inhibitor of cytochrome bc1 in the parasites T. annulata and T. parva (in vitro EC50 of 1.5 x 10-8 M and 6.1 x 10-10 M, respectively)
ABclonal Technology C2 Rabbit pAb
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Cayman Chemical ULIPRISTAL ACETATE 50MG
A selective progesterone receptor modulator (SPRM) that binds to human PR-A, PR-B, rabbit uterine PR, and rabbit thymic GR (EC50s = 8.5, 7.7, 13.6, and 15.4 nM, respectively); inhibits growth of IGROV-1 and SKOV3 human ovarian cancer cells (IC50s = 15.5 and 31.5 μM, respectively) even after resistance to combined cisplatin and paclitaxel treatment has developed; reverses the proliferative effect of progesterone on patient-derived germ-line mutant BRCA1 breast tissue xenografts in ovariectomized athymic mice; inhibits ovulation in female mice when administered within 6 h of treatment with hCG (40 mg/kg, i.p.)
Cayman Chemical LysylysylysIntrIfluoroac 100mg
A tripeptide; has been conjugated to oleyl amine for the generation of cationic liposomes with anticancer activity
Cayman Chemical ImeglImInhydrochlorIde 50mg
An anti-hyperglycemic compound; inhibits high-glucose- or tert-butyl hydroperoxide-induced cell death in HMEC-1 cells at 100 µM; reduces tert-butyl hydroperoxide-induced cytochrome c levels, as well as mitochondrial membrane permeability without affecting mitochondrial respiration, in HMEC-1 cells at 100 µM; decreases plasma glucose levels and increases plasma insulin levels in a rat model of high-fat diet-induced obesity at 150 mg/kg in the diet; reduces colonic balloon-induced pain-related muscle contractions in rats at 100 mg/kg; reduces colonic hyperpermeability in a rat model of LPS-induced IBS at 100 mg/kg
Cayman Chemical EmavusertIb 50mg
An IRAK4 inhibitor (IC50 = 31.7 nM); selective for IRAK4 over FLT3, Cdk2, Aurora A kinase, GSK3β, and MUSK at 1 µM; inhibits TLR2-, TLR5-, or IL-1R-mediated IL-6 release in isolated human whole blood (IC50s = 989, 696, and 1,375 nM, respectively); reduces tumor volume in an OCI-Ly3 DLBCL mouse xenograft model from 25-200 mg/kg