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An ionizable cationic lipid (pKa = 6.432); has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102
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A SUR1/Kir6.2 channel inhibitor (IC50 = 4.9 µM); selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively); increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets; reduces blood glucose levels in a mouse model of STZ-induced diabetes at 80 mg/kg
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A glycine-conjugated form of ursodeoxycholic acid; has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons; reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin in an astroglial cell model of neonatal hyperbilirubinemia; decreases the severity of symptoms and increases the amount of A. muciniphila in a mouse model of colitis at 500 mg/kg per day
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Recombinant mouse interferon-lambda 2 (IL-28A) supplied as a C-terminal His-tagged protein produced in E. coli and provided lyophilized from PBS with trehalose. The product is intended for cell-culture research, has >95% purity by reducing SDS-PAGE, and an apparent molecular weight of approximately 17-25 kDa. Store frozen and aliquot after reconstitution for extended stability.
Produced in E. coli and C-terminal His-tagged.
Lyophilized from 0.22 μm filtered PBS (pH 7.4) with trehalose.
Purity greater than 95% by reducing SDS-PAGE.
Apparent molecular weight ~17-25 kDa.
For cell culture use only.
Store at -20°C; after reconstitution stable 4°C for one week or frozen for longer.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More