Sera
Cayman Chemical R4AmIno3hydroxybutyrIc 100mg
A GABA receptor modulator; binds to GABAA and GABAB receptors (IC50s = 1 and 0.35 µM, respectively); inhibits GABA uptake in rat brain synaptosomes (IC50 = 67 µM); induces currents in a patch-clamp assay using Xenopus oocytes expressing human GABAC (EC50 = 19 µM); inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures at 20 mg/animal
Cayman Chemical BazedoxIfenacetate 50mg
An indole-based SERM that binds to both ERα (IC50 = 26 nM) and ERβ (IC50 = 99 nM); antagonizes 17β-estradiol-dependent and hormone-independent growth of breast cancer cell proliferation (80% reduction with 10 nM) in a manner related to cell cycle arrest and downregulation of cyclin D1 and ERα
Cayman Chemical IsoquercetIn 50mg
A flavonoid with diverse biological activities; reduces viral titers of H5N1 influenza isolates by 79.66% in a plaque assay at 1 ng/ml; inhibits apoptosis, increases cell viability, and decreases the level of ROS in an oxygen-glucose deprivation/reoxygenation assay in primary rat hippocampal neurons at 25, 50, and 100 UG/ml; decreases TNF-α-induced cell death in primary mouse hepatocytes (IC50 = 37.5 µM); reduces infarct volume and neurological symptoms in a rat model of MCAO at 50 mg/kg
Cayman Chemical MethIdathIon 100mg
An organophosphate insecticide; inhibits insect cholinesterase; reduces cattle lice (L. vituli, D. bovis, and H. eurysternus) infestation by 99.1% at 3.5 mg/kg; selectively toxic to lice over cattle, only inhibiting cattle plasma acetylcholinesterase activity by 20% with no effect on survival at 24 mg/kg; increases SCE and induces cell cycle arrest at the M1 phase in V79 cells at 40 μg/ml; increases liver enzyme activity, inhibits cholinesterase, and induces chronic liver inflammation in male beagle dogs from 1.4-4.7 mg/kg; induces loss of striation and myocytolysis of cardiomyocytes and reduces serum cholinesterase activity in rats 5 mg/kg
Cayman Chemical ScutelarIn 100mg
A flavone with diverse biological activities; inhibits proliferation of PC-9 and H1975 NSCLC cells and induces apoptosis and autophagy at 160 µM; reduces tumor growth in an H1975 mouse xenograft model at 30 and 60 mg/kg per day; decreases serum total cholesterol and LDL-cholesterol and increases HDL-cholesterol in a high-fat diet-induced mouse model of NAFLD at 25 and 50 mg/kg; decreases hepatic MDA, GOT, GPT activity, increases CAT and T-AOC activity, and increases the hepatic expression of PPARγ, PGC-1α, and Nrf2 in a mouse model of NAFLD; prevents deficits in spatial and novel object memory in rats in the Y maze and novel object recognition test, respectively at 5, 25, and 50 mg/kg per day
Cayman Chemical EntecavIrhydrate 100mg
An antiviral nucleoside analog and inhibitor of HBV reverse transcriptase (IC50 = 0.5 nM); reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with HBV (EC50 = 3.75 nM); reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection at 1 mg/kg
Cayman Chemical TopIroxostat 50mg
An inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM); inhibits ABCG2 in isolated human plasma (IC50 = 0.18 µM); increases LPS-induced decreases in Bcl-2 levels and decreases LPS-induced increases of Bax and cleaved caspase-3 levels in H9c2 rat cardiomyocytes at 5 µM; chronic administration results in the presence of urinary xanthine crystals and induces nephropathy in rats at 0.2 and 1 mg/kg, respectively
Cayman Chemical LasofoxIfentartrate 50mg
A third-generation SERM that selectively binds to human ERα (IC50 = 1.5 nM) and inhibits bone loss in ovariectomized rats; used in the treatment of postmenopausal osteoporosis and ER-positive breast cancer; also acts as an inverse agonist at the CB2 cannabinoid receptor
Cayman Chemical ndrographolIde 100mg
A diterpenoid compound that inhibits NF-κB binding to DNA promoters and induces expression of the CYP1A enzymes to produce immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, antiviral, antibacterial, antidiabetic, antioxidative stress, antipyretic, antiedematogenic, and antinociceptive activities
Cayman Chemical CarteololhydrochlorIde 50mg
A β-adrenergic receptor antagonist (Kd = 13 nM); blocks isoproterenol-induced increases in heart rate, contractile force, and blood pressure in vagotomized dogs (ED50s = 2.3, 3.1, and 1.8 UG/kg, respectively); the (R) and (S)-enantiomers EAch reduce intraocular pressure in rabbits (1% solution)
Cayman Chemical OrbIfloxacIn 100mg
A fluoroquinolone antibiotic used in animals, including dogs, cattle, and swine, to combat gastrointestinal and respiratory infections
Cayman Chemical FluphenazInN2chLRoethn 50mg
A derivative of fluphenazine that contains an alkylating chlorethylamine chain, which produces irreversible protein binding; a relatively selective, irreversible antagonist of D2 receptors both in vitro (IC50 = 100 nM) and in vivo; irreversibly inhibits calmodulin at higher doses (IC50 = 10 µM)
Cayman Chemical 3SIalylactosesodIum salt 100mg
An abundant oligosaccharide in the milk of many mammals, including cows and humans, particularly postpartum; avidly binds several viral strains, including strains of influenza, HIV-1, reovirus, and polyomavirus, in some cases altering viral infectivity