Sera
Cayman Chemical S10hydroxyCamptothecIn 100mg
An inhibitor of topoisomerase I that demonstrates less toxicity than its parent compound; demonstrates strong anti-tumor activity against a wide range of experimental tumors including L1210 leukemia cells (IC50 = 1.15 μM)
Cayman Chemical 4NItrophenyl DCelobIosId 50mg
An enzyme substrate; has been used to characterize function of endoglucanase 1 from T. harzianum, β-glucosidase from T. xylanolyticum, and GH3 aryl β-glucosidases from A. oryzae
Cayman Chemical namInhydrochlorIde 50mg
A natural degradation product of neomycin; a common core molecule used in the synthesis of aminoglycoside antibiotics
Cayman Chemical HomoplntagInIn 50mg
A flavonoid glycoside; scavenges DPPH radicals (IC50 = 0.35 UG/ml); reverses hydrogen peroxide-induced decreases in GSH levels and GPX and SOD activity in HL-7702 cells from 1-100 UG/ml; prevents palmitic acid-induced increases in protein levels of TLR4, MyD88, caspase-1, and IL-1β levels in HUVECs at 1 and 10 µM; decreases serum ALT, AST, TNF-α and IL-1 levels, as well as reduces liver inflammatory cell infiltration and hepatocyte necrosis in a mouse model of immunological liver injury induced by BCG vaccine and LPS
Cayman Chemical TrIamcInolon acetonIde 100mg
A synthetic corticosteroid; decreases cytokine levels, the firing rate of sensory neurons, and mechanical hypersensitivity in a rat spinal nerve ligation model at 1.5 mg/kg administered prior to and following surgery for three days; decreases outflow facility in a mouse model of steroid-induced glaucoma when 20 µl of a 40 mg/ml suspension is administered subconjunctivally
Cayman Chemical BaloxavIr MarboxIl 100mg
A prodrug form of the antiviral baloxavir acid; inhibits CEN and CEN/RdRp activity in cell-free assays (IC50s = 530 and 340 nM, respectively); prevents mortality in a mouse model of influenza A and B viral infection at 5 or 50 mg/kg twice in a single day; reduces lung viral titers, body weight loss, and mortality in a mouse model of influenza A and B viral infection when administered 72 hours post-infection at 50 mg/kg
Cayman Chemical SB-206553hydrochlorIde 50mg
A 5-HT2C (Ki = 12.6 nM) and 5-HT2B receptor antagonist; selective for 5-HT2C and 5-HT2B over a panel of eight 5-HT receptor subtypes and six additional receptors (Kis = >1 µM for all); inhibits 5-HT-induced contraction of isolated rat stomach fundus (EC50 = 4.8 nM); inhibits 5-HT-induced inositol phosphate release in HEK293 cells expressing human 5-HT2C receptors (EC50 = 3.16 nM); increases the time spent in active social interaction in a social interaction test and increases punished responding in the Geller-Seifter conflict test in rats at 2 and 20 mg/kg; increases suppressed responding in a marmoset conflict model of anxiety at 15 and 20 mg/kg
Cayman Chemical AmIprofos-methyl 50mg
An herbicide; reversibly decreases H. vulgare root and shoot length and inhibits in vitro paclitaxel-induced tubulin polymerization in a dose-dependent manner; completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM; inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM; inhibits the growth of P. falciparum (IC50 = 3.5 μM); completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM
Cayman Chemical AsoxImechlorIde 50mg
An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning
Cayman Chemical DImethIndenmaleate 100mg
A histamine H1 receptor antagonist (Ki = 1.5 nM); selective for histamine H1 receptors over M1 mAChRs and 5-HT receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively); alone or in combination with icodextrin decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgical-induced abdominal trauma in rabbits at 0.1 mg/kg
Cayman Chemical LIpId III-45 50mg
An ionizable cationic lipid; has been used in the generation of LNPs for the delivery of mRNA in vivo; LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice; LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting claudin-18.2 to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model
Cayman Chemical AgomelatIn 100mg
A melatonin receptor agonist (Kis = 0.14 and 0.41 nM for MT1 and MT2, respectively) and 5-HT2B and 5-HT2C antagonist (Kis = 0.26 and 0.71 nM, respectively); inhibits the 5-HT2-mediated penile erection response in rats at 40 mg/kg; increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats at 20-80 mg/kg; reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice in a transgenic neuroendocrine model of depression at 10 mg/kg
Cayman Chemical MenaquInon 4 100mg
A homolog of vitamin K2; formed primarily via conversion of vitamin K1 in vivo; halts the cell cycle at the G1 phase in HepG2, Hep3B, and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner; inhibits IκB, IκBα phosphorylation, and the transcriptional activity of NF-κB
Cayman Chemical VInblastInsulfate 50mg
An antimicrotubule drug used to treat Hodgkin’s lymphoma, non-small cell lung, breast, head and neck, and testicular cancer; inhibits steady-state tubulin addition to microtubules (Ki = 0.18 μM) and inhibits B16 melanoma cell proliferation (IC50 = 1 nM)
Cayman Chemical Schzndrn 50mg
A lignan with diverse biological activities; induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells at 100 μM; prevents glutamate-induced cytotoxicity, inhibits production of NO and ROS, and preserves the mitochondrial membrane potential in isolated rat cortical cells at 10 and 100 μM; reduces cisplatin-induced apoptosis in HK-2 cells; reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats at 1 and 10 mg/kg; enhances oxotremorine-induced tremors in mice; reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy at 10 mg/kg