Sera
Cayman Chemical NpentadecnoylLHomoserIn 50mg
A bacterial quorum-sensing signaling molecule; activates the LasR quorum sensing receptor of bacteria in a reporter assay; induces GFP production in a P. putida F117 reporter strain expressing the pKR-C12 quorum-sensing operon at 0.094 nM
Cayman Chemical -nabasInhydrochlorIde 50mg
An alkaloid agonist of nAChRs with teratogenic activity; induces depolarization of TE 671 cells endogenously expressing human fetal muscle-type nAChRs (EC50 = 10.1 µM); binds to α4β2 subunit-containing nAChRs in K177 cells (Ki = 37.63 nM); teratogenic in vivo, inducing congenital defects, including cleft palate and severe fixed excessive flexure of carpal joints, in piglets when administered to pregnant dams during gestation days 43-53 at a dose of 2.6 mg/kg twice per day
Cayman Chemical Chrysophnol 50mg
An anthraquinone with diverse biological activities; induces necrosis in J5 human liver cancer cells at 25, 50, 75, 100, and 200 µM; reduces LPS-induced production of NO and PGE2 and inhibits LPS-induced DNA oxidation in BV-2 microglia at 5, 10, and 50 µM; decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of DSS-induced colitis at 5 mg/kg; increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of MCAO-induced ischemia-reperfusion injury at 0.1, 1, and 10 mg/kg
Cayman Chemical DLRythroPPMPhydroCLOrId 100mg
A stereoisomer of DL-threo-PPMP; has no effect on glucosylceramide synthetase activity; used as a negative control for DL-threo-PPMP, D-threo-PPMP, and L-threo-PPMP inhibitory activity
Cayman Chemical SpIroxamIn 100mg
A tertiary amine fungicide; an inhibitor of Δ14 reductase/Δ8→Δ7 isomerase; inhibits the growth of N. parvum, B. dothidea, D. seriata, and L. theobromae isolates from grape vines (EC50s = 0.97-10.28 mg/L); reduces network formation in rat cortical cultures from 0.03-30 μM; cytotoxic to MDA-kb2 cells (EC20 = 9.29 μM)
Cayman Chemical IsoguvacInhydrochlorIde 100mg
A GABAA; binds to rat synaptic cortical membranes (Ki = 55 nM); activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively); inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM); inhibits potassium/low magnesium-induced seizures in rat pups; chronic administration improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of ASD at 2 mg/kg
Cayman Chemical OxychlororaphIn 100mg
A microbial metabolite with diverse biological activities; cytotoxic to A549, HeLa, and SW480 cancer cells (IC50s = 32-40 μM); halts the cell cycle at the G1 phase and induces apoptosis in A549 cells; active against Streptomyces bacteria and T. mentagrophytes, E. floccosum, C. albicans, M. audouini, and B. dermatitidis fungi from 12.5 to 50 ppm
Cayman Chemical BenzetImIdehydrochlorIde 100mg
A muscarinic acetylcholine receptor antagonist; induces mydriasis and inhibits pilocarpine-induced salivation and lacrimation in rats (ED50s = 0.06 and 0.04 mg/kg, respectively)
Cayman Chemical AmbenonIumchlorIde 50mg
An AChE inhibitor (IC50 = 0.7 nM); selective for AChE over BChE (IC50 = 6.82 µM); increases the secretion of APP in primary rat basal forebrain cells at 10 µM; induces repetitive firing of electrically stimulated gastrocnemius muscle in anesthetized cats at 5 UG/animal; inhibits tubocurarine- or decamethonium-induced paralysis in anesthetized cats at 3 UG/animal
Cayman Chemical trns-nrolIdol 50mg
A sesquiterpene with diverse biological activities; inhibits the growth of S. aureus, B. subtilis, E. coli, and S. cerevisiae; reduces viability of CaCo-2 adenocarcinoma cells (IC50 = 28.7 mg/L); insecticidal against A. aegypti (LC50 = 9 mg/L)
Cayman Chemical AdefovIr dIpIvoxIl 50mg
A prodrug form of adefovir; inhibits HBV DNA synthesis in HepG2 2.2.15 cells infected with HBV (EC50 = 0.517 μM); cytotoxic to HepG2 2.2.15 cells (CC50 = 540 μM); inhibits HBV replication in the liver of HBV transgenic mice (ED50 = 0.2 μmol/kg per day)
Cayman Chemical AloglIptInbenzoate salt 100mg
An orally bioavailable DPP-4 inhibitor (IC50 = 6.9 nM) that is selective for DPP-4 over DPP-2, DPP-8, DPP-9, prolyl endopeptidase, FAP, and tryptase (IC50s = >100,000 nM); inhibits DPP-4 activity in vivo in rats, dogs, and cynomolgus monkeys (EC50s = 3.4, 4.9, and 5.6 ng/ml, respectively, in plasma); increases plasma GLP-1 and insulin levels and decreases blood glucose levels during an oral glucose challenge in Zucker fa/fa rats (10 mg/kg); decreases plasma DPP-4 activity and increases GLP-1 levels in diabetic ob/ob mice when administered for 29 days (2.8 mg/kg per day)
Innovative Research Inc Rat IgG Depleted Srm 100ml
Rat IgG Depleted Serum 100ml - Rat IgG Depleted Serum from Innovative Research has been purified from normal rat serum by affinity chromatography. This is a Frozen liquid. This product can be used as a control in applications like ELISA and Western Blot. It can be used for a wide range of in vitro applications, including tissue culture and more.
Cayman Chemical aPyroldInobutIothIophenon 50mg
An analog of α-PBP that has a thiofuran group in place of the phenyl group