Sera
Cayman Chemical Blonsern 100mg
A mixed antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors (Kis = 0.14, 0.49, and 0.81 nM, respectively) that also binds to 5-HT6 (Ki = 11.7 nM); developed as a novel antipsychotic that displays 20- and 94-fold higher affinity for D2 receptors compared to haloperidol and risperidone, respectively
Cayman Chemical SARACATINIB 50MG
A dual inhibitor of c-Src and Abl (IC50 = 2.7 and 30 nM, respectively); less effectively inhibits other kinases; blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival; reduces osteoclast bone resorption
Cayman Chemical BalsalazIde 50mg
A prodrug form of 5-ASA; cleaved by bacterial azoreductases in the intestinal lumen to release 5-ASA; decreases IL-2 levels and increases IL-6 levels in the serum and colonic mucosa membrane, as well as decreases micro- and macroscopic colonic damage, in a rat model of DNCB-induced colitis at 600 mg/kg per day
Cayman Chemical Alcaftadn 50mg
A H1 histamine receptor antagonist (IC50 = 8.6 nM) with anti-inflammatory and mast cell stabilizing effects; reduces edema and erythema in a guinea pig model of allergic conjunctivitis (ED50 = 0.1 mg/kg); has been used in clinical formulations in eye drops for treatment of ocular itching associated with allergic conjunctivitis
Cayman Chemical R S-natbIn 50mg
A minor tobacco alkaloid; an agonist of α4β2 and α6/α3β2β4 subunit-containing nAChRs (EC50s = 6.1 and 3.6 µM, respectively); selective for these nAChRs over α3β4 subunit-containing nAChRs or α7 nAChRs (EC50s = 70.6 and 158.5 µM, respectively); stimulates dopamine release from isolated rat brain synaptosomes (EC50s = 1.76 and >100 µM, respectively); has anxiolytic-like activity in zebrafish at 10 mg/L; decreases disease severity in a mouse model of thyroglobulin, CFA, and M. tuberculosis immunization-induced moderate experimental autoimmune thyroiditis; decreases food and nicotine self-administration in monkeys (ED50s = 2.085 and 0.854 mg/kg, respectively); has been used as a biomarker of tobacco use
Cayman Chemical RopInIrolehydrochlorIde 50mg
A dopamine D2 receptor agonist (Ki = 29 nM in a radioligand binding assay); selective for D2 over D1 dopamine receptors (Ki = >100,000 nM), as well as a panel of adrenergic, serotonin, benzodiazepine, and GABA receptors (IC50s = >9,000 nM); reduces spontaneous locomotor activity in mice at doses less than 50 mg/kg but increases it at a dose of 100 mg/kg; induces contralateral asymmetry in an open field test in 6-OHDA-lesioned mice; reverses locomotor deficits and restores interest in novel stimuli in a marmoset model of MPTP-induced Parkinson's disease
Cayman Chemical EstramustIn PhosphATsodIu 50mg
A derivative of estradiol that destabilizes microtubules (Kds = 10 and 15 µM for MAP-1 and MAP-2, respectively); induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells; induces apoptosis in U87MG human malignant glioma cells
Cayman Chemical GemcItabInhydrochlorIde 100mg
An active metabolite of NUC-1031 and gemcitabine elaidate and a prodrug form of gemcitabine di- and triphosphates; cytotoxic to HepG2 and A549 cells (IC50s = 5.2 and 16 nM, respectively); inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models; sensitizes tumors to PD-1-targeting antibodies, decreases the number of tumor-infiltrating Tregs, and increases survival in an MC-38 syngeneic mouse model of colon carcinoma at 12 mg/kg
Cayman Chemical Crotonsde 50mg
A guanosine analog with diverse biological activities; cytotoxic to P338, L5178Y, Sp2/O, HL-60, and Raji cells in vitro (EC50s = 21, 370, 120, 70, and 400 μM, respectively); reduces tumor growth by 60% in S-180 sarcoma and Ehrlich carcinoma solid tumor mouse models at 48 mg/kg per day for 12 days; has been used as an internal standard for the semi-quantitative analysis and comparison of RNA metabolites in MCF-7 breast cancer cells and MCF-10A mammary epithelial cells; decreases the force and rate of contraction in isolated guinea pig atria (EC50s = 2.8 and 17.8 μM, respectively); reduces carotid blood pressure in anesthetized cats at 0.5 μmol/kg
Cayman Chemical RopIvacaInhydrochLRId 100mg
A potent and reversible sodium channel blocker; induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve; depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine
