Sera
Cayman Chemical Alntolacton 50mg
A sesquiterpene lactone with diverse biological activities; inhibits LPS-induced increases in nitric oxide, IL-6, and TNF-α production in RAW 246.7 cells by 76.09, 81.54, and 71.23%, respectively, at 10 μM; decreases cell viability, GSH levels, and the mitochondrial membrane potential, induces apoptosis, and increases ROS generation in HepG2 cells at 40 μM; inhibits phosphorylation and nuclear translocation of STAT3 in MDA-MB-231 cells; reduces tumor growth in an MDA-MB-231 mouse xenograft model at 2.5 mg/kg
Cayman Chemical Valbenazn 50mg
An inhibitor of VMAT2 (Kis = 110 and 150 nM in rat striatum homogenates and human platelets, respectively); selective for VMAT2 over a panel of 80 receptors, transporters, and ion channels; increases ptosis in rats
Cayman Chemical AdenylosuccInIc ACDamonIu 50mg
A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD
American Research Products Inc CATALASE CAT FLUOROMETRIC KIT
5000265017 CATALASE CAT FLUOROMETRIC KIT
Cayman Chemical -O-Desmethyl VenlafaxIn 50mg
An active metabolite of venlafaxine; inhibits NET and SERT (IC50s = 47.3 and 531.3 nM, respectively); selective for NET and SERT over 50 non-transporter targets; increases extracellular NE in the male rat hypothalamus and 5-HT in the same region when used in combination with WAY-100635; reduces immobility time in the forced swim test in a rat model of cognitive deficits and depression induced by MI when compared with MI-vehicle control animals 16 weeks following MI; improves learning in the passive avoidance step-down test two weeks following MI compared to MI-vehicle control rats and spatial memory in the Morris water maze 16 weeks following MI
Cayman Chemical 25P-NBOMehydrochlorIde 50mg
A phenethylamine that binds 5-HT2A and 5-HT2C with similar affinities (pKis = ~9 for both)
Cayman Chemical Linolenic ACD 100mg
γ-Linolenic acid is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. γ-Linolenic acid produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.{2361}
Cayman Chemical MEGsulfate 100mg
MEG is a selective iNOS inhibitor and scavenger of peroxynitrite. The EC50 values for inhibition of iNOS (LPS-treated rat lung), eNOS (bovine endothelial), and nNOS (rat brain) are 11.5, 110, and 60 µM, respectively.{7417} MEG reacts with peroxynitrite with a second order rate constant of 1,900 M−1s−1 at 37°C.{4278} MEG has potent anti-inflammatory activity, which may be due to the combined effect of MEG acting as an inhibitor of iNOS and as a scavenger of peroxynitrite.{5922}
Cayman Chemical Apum lptopylum Bgaptn 100mg
A furanocoumarin derivative with diverse biological activities; decreases the viability of DLD-1 and LoVo colorectal cancer cells in a concentration-dependent manner, halts the cell cycle at the G0/G1 and sub-G1 phases, and induces apoptosis at 50 μM; has photosensitizing activity; increases the number of sunburn cells in guinea pig skin in response to UVA radiation; increases the pain threshold in assays for mechanical, cold, and hot allodynia, as well as mechanical hyperalgesia, in a rat model of vincristine-induced neuropathic pain at 10 mg/kg; inhibits vincristine-induced increases in plasma TNF-α and IL-1β levels and decreases in GSH levels in the spinal cord and sciatic nerve in rats; inhibits CYP3A4 (IC50 = ~25 μM) in human liver microsomes
Cayman Chemical FlunIxInmeglumIn 50mg
A COX inhibitor (IC50s = 3.24 and 0.55 µM for COX-1 and COX-2, respectively); inhibits carrageenan-induced PGE2 and TXB2 production in sheep exudate and serum, respectively, at 1.1 mg/kg; has anti-inflammatory, analgesic, and antipyretic activity in horses at 1.1 mg/I/kg
Cayman Chemical PergolIdemesylate 100mg
A potent and selective Syk inhibitor (IC50 4 nM) inhibits 92 of Syk activity while other kinases retain 70 activity at a concentration of 50 nM in a panel of 270 kinases inhibits convulxin-induced aggregation of human platelet-rich plasma (IC50 2.5 M) prevents thrombosis in a transgenic mouse model of heparin-induced thrombocytopenia induces CLL B cell apoptosis and inhibits the secretion of chemokines CCL3 CCL4 and CXCL13 inhibits CLL B cell chemotaxis and pseudoemperipolesis
Cayman Chemical LIgnoceroyl EthnolamIde 50mg
A member of the family of fatty N-acyl ethanolamines collectively called endocannabinoids
Cayman Chemical 6-O-SulfocyclodextrInsod 50mg
An anionic cyclodextrin; has been used for the chiral separation of nadolol racemates by capillary electrophoresis