An atypical antipsychotic a dopamine D2 and D3 receptor antagonist (Kis 5.37 and 6.45 nm respectively) inhibits head twitches induced by 5-hydroxy-L-tryptophan in mice (ED50 0.13 mg/kg) an a2-AR antagonist reducing the clonidine-stimulated hind limb flexor reflex in rats blocks apomorphine- and methamphetamine-induced gnawing behavior and body turning in rats induces catalepsy and inhibits apomorphine-induced vomiting in dogs