Human Sera
Cayman Chemical TebufenozIde 100mg
An insecticide and ecdysone receptor agonist (IC50 = 0.85 nM); induces a premature molt and is lethal to S. litura third instar larva (LD50 = 0.33 µM per larva); inhibits p-glycoprotein in LLC-PK1 porcine kidney epithelial cells transfected with MDR1 (IC50 = 21.5 µM); decreases colony formation and induces apoptosis and cell cycle arrest in HeLa cells when used at concentrations ranging from 50 to 200 UG/ml
Cayman Chemical Tocopherol 50mg
A form of vitamin E with antioxidant and anti-inflammatory properties; traps and detoxifies reactive nitrogen oxide species, including nitrogen dioxide, in cell-free assays; reduces PGE2 synthesis induced by LPS in RAW 264.7 macrophages and by IL-1β in A549 cells (IC50s = 7.5 and 4 μM, respectively); inhibits LPS-induced nitrite release and iNOS expression in RAW 264.7 cells at 10 μM and reduces COX-2 activity in A549 cells pretreated with IL-1β; serum levels are decreased in patients with cardiovascular disease
Cayman Chemical GentIopIcrIn 100mg
An iridoid glycoside with diverse biological activities; attenuates ANIT-induced acute cholestasis and liver damage and reverses bile acid dyshomeostasis in mice at 130 mg/kg; increases the paw withdrawal threshold in the cold-plate test and latency to paw withdrawal in the plantar test in mice at 25, 50, and 100 mg/kg; decreases NMDA receptor-mediated EPSCs in the nucleus accumbens and reverses morphine-induced conditioned place preference in mice at 100 mg/kg
Cayman Chemical OrItavncInphosphate 50mg
A semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria; inhibits the growth of clinical isolates of MRSA, MSSA, VREF, VSRF, and other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L); inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for single dose); improves survival of mice in an inhalation model of B. anthracis Ames anthrax
Cayman Chemical CypermethrIn 50mg
A type II pyrethroid insecticide; prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system; reduces survival of ticks in vitro (1-1.5 mg); reduces survival of lice in sheep fleece and prevents re-infestation in contact-challenged sheep (5 and 10 ppm); induces developmental neurotoxicities in zebrafish (50 to 200 μg/L); induces Parkinson's disease-like neurodegeneration in rats (15 mg/kg twice weekly for 24 weeks)
Cayman Chemical Lpofermat 50mg
An inhibitor of fatty acid transport (IC50 = 4.84 μM in Caco-2 cells); inhibits uptake of long- and very long-chain, but not medium-chain, fatty acids in mmC2C12, rnINS-1E, Caco-2, and HepG2 cells (IC50s = 3-6 μM); inhibits induction of BiP and CHOP, apoptosis, and lipid droplet accumulation, as well as reduces production of ROS and reverses decreases in GSH levels induced by palmitate in HepG2 and INS-1E cells; inhibits absorption of 13C-oleate in mice at 500 mg/kg
Cayman Chemical Tocopherol 50mg
A lipid-soluble form of vitamin E with antioxidant activity; scavenges DPPH radicals (EC50 = 68.2 μM); inhibits LPS-induced COX-2 gene expression in mouse RAW 264.7 macrophage cells at 100 μM
Cayman Chemical TelotrIstat EtIprate 50mg
A prodrug form of telotristat; reduces levels of 5-HT in mouse jejunum and blood at 15-300 mg/kg; inhibits increases in IL-1β and IL-6 levels, histological damage in the colon, and weight loss in a mouse model of trinitrobenzene sulfonic acid-induced colitis at 200 mg/kg; reduces colonic levels of MPO, IL-1β, and IL-17, as well as worm burden, in mice infected with T. muris at 300 mg/kg
Cayman Chemical GR89696fumarate 50mg
A κ-opioid receptor agonist; inhibits twitch responses in isolated mouse vas deferens (IC50 = 0.12 nM); reduces acetylcholine-induced writhing in mice (ED50 = 0.0005 mg/kg); reduces hippocampal neuronal loss in a gerbil model of cerebral ischemia induced by bilateral carotid artery occlusion at 10 and 30 mg/kg
Cayman Chemical Myrislignan 50mg
A lignan with diverse biological activities; inhibits hypocotyl or root growth of cress (IC50s = 429 and 517 µM, respectively); inhibits production of NO, increases in iNOS and COX-2 levels, and release of TNF-α and IL-6 in LPS-stimulated RAW 264.7 cells at 50 UG/ml; inhibits proliferation of, and induces apoptosis in, A549 lung cancer cells; reduces tumor growth in an A549 lung cancer mouse xenograft model at 3, 5, and 8 mg/kg; decreases parasite burden in the liver, brain, and spleen in a mouse model of T. gondii infection at 100 mg/kg
Cayman Chemical SematIlIdehydrochlorIde 50mg
A class III antiarrhythmic agent; prolongs electrically stimulated APD and increases ERP in isolated guinea pig left atria; decreases spontaneous sinoatrial beating rates and induces ERP prolongation of the atrioventricular node in isolated perfused canine hearts; increases ERP, prolonging cardiac refractoriness, in situ in open-chest dog hearts at 1 mg/kg; inhibits PES-induced arrhythmias in dogs
Cayman Chemical CyntrnIlIprole 50mg
An anthranilic diamide insecticide; an allosteric RyR activator; 300- to 500-fold selective for insect over mouse RyR1, greater than 2,000-fold selective for insect over rat RyR2, and inactive in human IMR32 cells expressing RyR2 and RyR3; active against the diamondback moth (PP50 = 0.1 ppm); induces mortality of the green peach aphid, cotton melon aphid, and white fly (EC50s = 1.1, 0.4, and 5.8 ppm, respectively)
Cayman Chemical AzImIlIdehydrochlorIde 50mg
A class III antiarrhythmic agent; blocks IKr and IKs currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively); prolongs APD in isolated calf Purkinje fibers and ventricular trabeculae from 0.1-10 μM; increases the ERP in isolated perfused guinea pig hearts and ferret papillary muscles; increases ERP and the absolute refractory period and decreases heart rate in dogs from 0.3-30 mg/kg; reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia; prevents sustained and non-sustained ventricular tachyarrhythmias in dogs from 10-30 mg/kg
Cayman Chemical GInsenosIde Rb3 100mg
A steroid glycoside with diverse biological activities; inhibits OGD-induced JNK-mediated activation of NF-κB and apoptosis in H9c2 mouse cardiac myoblasts; reduces myocardial apoptosis and production of ROS in a rat model of myocardial ischemia-reperfusion injury at 20 mg/kg; prevents increases in serum creatinine, BUN, MDA, and decreases in SOD activity and GSH levels, as well as inhibits renal cell apoptosis in a mouse model of cisplatin-induced nephrotoxicity at 10 and 20 mg/kg; decreases the abundance of cancer cachexia-associated gut microbiota and the number of polyps in the ApcMin/+ mouse model of colon cancer; decreases immobility time in the forced swim and tail suspension tests in mice
