Human Sera
Cayman Chemical FentIconazolenItrate 50mg
An internal standard for the quantification of fenofibrate by GC- or LC-MS
Cayman Chemical Pogostmons hrba Pogoston 50mg
A ferroptosis inhibitor (IC50 10 nM for erastin-induced ferroptosis in IMR-32 cells) decreases iron-induced plasma LDH levels in a mouse model of acute iron poisoning at 20 Umol/kg not toxic to mice at 20 Umol/kg for four weeks
Cayman Chemical CyntrnIlIprole 50mg
An inhibitor of staphylococcal FabI (Ki 12 8 nM) selective for isolates of methicillin-susceptible and methicillin-resistant S aureus (MIC90s 0 008 g/ml) over isolates of S pneumoniaeBhemolytic streptococci Enterococcus Enterobacteriaceae non-fermentative Gram-negative bacilli and M catarrhalis (MIC90s 4 g/ml) increases survival in a murine acute lethal septicemia model at 1 mg/kg
Cayman Chemical 4NItrophenylNacetylDgl 100mg
A cationic amphipathic lipid DDA liposomes containing an Ag85B-ESAT-6 antigen induce antigen deposition at the injection site in mice has been used in the study of lipid bilayer dynamics
Cayman Chemical LIxIsenatIdeacetate 50mg
An ionizable cationic lipid has been used in the generation of LNPs LNPs containing cKK-E15 and encapsulating Cre mRNA and induce the expression of Cre in Kupffer cells endothelial cells and hepatocytes in Ai14 mice translation of mRNA delivered to the liver by LNPs containing cKK-E15 is inhibited by LPS in Ai14 mice but not by low-grade chronic liver inflammation in a B16/F10 murine model of cancer-induced inflammation the delivery of LNPs containing cKK-E15 is not dependent upon ApoE or Ldlr expression in mice
Cayman Chemical -LIquIrItIgenIn 100mg
A polyphenol with diverse biological activities inhibits the formation of superoxide radicals singlet oxygen hydrogen peroxide and hydroxyl radicals in vitro (IC50s 26 7 0 83 0 39 and 25 07 Umol/L respectively) reduces hydroxyl radical-induced damage to plasmid DNA prevents LPS-induced release of TNF-a IL-1B and IL-6 expression of JNK and p38 and nuclear translocation of NF-KB in RAW 264 7 cells from 12 5-50 UM reduces serum levels of TNF-a IL-1B and IL-6 and decreases pulmonary edema pulmonary congestion and thickening of the alveolar wall in a mouse model of LPS-induced acute lung injury inhibits osteoclast formation polarization and osteoclastic bone resorption in vitro reduces titanium particle-induced bone erosion and the number of mature osteoclasts in mice
Cayman Chemical AcepromazInmaleate 100mg
A carbamate insecticide an inhibitor of acetylcholinesterase (IC50 4 3 UM) an antagonist of a4B4 subunit-containing nicotinic acetylcholine receptors (IC50 165 UM for the rat receptor) lethal to German cockroaches (LD50s 2 45 4 73 and 1 06 g/insect for newly emerged males newly emerged females and 4-week-old nymphs respectively) induces LDH release from and inhibits the growth of flounder gill cells (IC50s 86 59 and 89 96 g/ml respectively) induces yolk sac and pericardial edema in zebrafish embryos at 100 and 200 g/ml inhibits rat blood and brain cholinesterase decreases ambulation and rearing in an open field test and increases latency to escape foot shock after an audio stimulus in the two-way active avoidance box in rats at 8 3 mg/kg
Cayman Chemical ML-241hydrochlorIde 50mg
An analytical reference standard that is structurally similar to known phytocannabinoids intended for research and forensic applications
Cayman Chemical 2Fluoro2deoxyarabInoCy 50mg
An analytical reference standard categorized as a sedative induces sedation in dogs has analgesic activity alone and an additive analgesic effect in combination with fentanyl and morphine in rats has been found in fentanyl samples seized by law enforcement intended for analytical forensic applications
Cayman Chemical 2-BFIhydrochlorIde 50mg
An ACE inhibitor (IC50 2.6 nM) and active metabolite of imidapril inhibits bradykinin-induced contractions in isolated guinea pig ileum (IC50 1.7 nM) reduces CCL2-induced adhesion of THP-1 monocytes to TNF-a-activated HUVECs at 50 nM inhibits the angiotensin I-induced pressor response in unanesthetized normotensive rats at 1 mg/kg
Cayman Chemical LenacapavIr 50mg
A protein-modifying agent introduces sulfhydryl groups to proteins used in conjunction with the protein cross-linking reagent SMCC in the conjugation of proteins with IgG antibodies for use in ELISAs
Cayman Chemical CNDAChydrochlorIde 50mg
An ionizable cationic lipid has been used in the generation of single-component LNPs for the delivery of siRNA LNPs containing lipid OA2 and siRNA targeting Socs1 decrease Socs1 expression by ~50 in isolated mouse BMDCs vaccination with ovalbumin-induced isolated mouse BMDCs transfected with LNPs composed of lipid OA2 and Socs1-targeting siRNA increases survival and decreases tumor volume in a B16-OVA murine melanoma model
Cayman Chemical PropIophenon 50mg
A quaternary ammonium-containing cationic surfactant CMC 15.7 and 8.1 mM in water and PBS pH 7.4 respectively binds to DNA active against L. monocytogenes (MIC 120 mg/L)
Cayman Chemical 1PalmItoyl2oleoyl3lInole 50mg
A peptide and an active metabolite of GLP-1 (7-36) amide inhibits hydrogen peroxide-induced decreases in ATP levels and t-BHP-induced increases in ROS levels in primary mouse hepatocytes and H-4-II-E cells at 100 nM reduces body weight gain the ratio of weight gain to food intake and hepatic gluconeogenesis in a mouse model of HFD-induced obesity at 18.5 nmol/kg per day decreases plasma levels of glucose and insulin and hepatic triglyceride levels in a mouse model of VHFD-induced obesity when infused at 18.5 nmol/kg per day
Cayman Chemical MolsIdomIn 100mg
A TLR7 agonist selectively induces NF-KB signaling in HEK293 cells expressing recombinant human TLR7 but not HEK293 cells expressing recombinant human TLR8 or TLR9 at 1 UM induces IFN-a production in plasmacytoid dendritic cell-enriched isolated human PBMCs from 10-1000 ng/ml delays the onset of lung metastasis in a B16/F10 murine melanoma model at 150 mg/kg