Human Sera
Cayman Chemical Hexaconazole 50mg
A triazole fungicide; inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol; curative against powdery mildew on barley plants at 6.7 mg/L; improves water, proline, and protein contents as well as increases non-enzymatic and enzymatic antioxidant and apigenin-7-glucoside content in M. chamomilla plants during a water deficit stress tolerance test at 15 mg/L; inhibits the differentiation of mouse embryonic stem cells into cardiomyocytes (EC50 = 16.6 μM); induces bone morphological defects in mouse fetuses
Cayman Chemical IsovalerylLcarnItInchlor 100mg
A naturally occurring acylcarnitine; formed via metabolic conversion of L-leucine; increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes at 1 mM; inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver at 77 and 100 μM, respectively
Cayman Chemical ImatInIbmesylate 100mg
An inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit; inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC50s = ~0.3 and ~0.1 μM, respectively); inhibits the proliferation of Bcr-Abl-dependent R10(–) cells (IC50s = ~35-40 nM) and HMC-1 cells expressing constitutively active c-Kit in a concentration-dependent manner; prolongs survival in a mouse model of chronic myeloid leukemia at 100 mg/kg twice daily; inhibits replication of MERS-CoV and SARS-CoV in Vero E6 cells at 25 and 50 µM; reduces viral titers in IBV-infected Vero cells at 10 µM
Cayman Chemical R3Oxocyclopentncarboxy 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical RTetrahydrofurn3ylamIn 50mg
A synthetic intermediate useful for pharmaceutical synthesis.
MOLECULAR DEPOT LLC High Vitamin D - 50 mL
High Vitamin D Serum (50 mL) is human serum containing high levels of 25-OH vitamin D (200 ng/mL of total 25-OH vitamin D) This product is useful for the dilution of 25-OH vitamin D solutions as well as the research and development of 25-OH vitamin D high and low working solutions This product is liquid stable For in vitro research use only
Cayman Chemical LauroylLcarnItInchLRIde 50mg
An acylcarnitine and a quaternary ammonium-containing cationic surfactant; has been used to permeabilize porcine enterocytes for delivery of the polar fluorescent probe lucifer yellow
Cayman Chemical N3oxohexadecnoylLHomose 50mg
An unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria
Cayman Chemical NaphthofluoresceIn 50mg
A cell-permeable inhibitor of furin (IC50 = 12 μM); inhibits furin-mediated cleavage of the pro-form of MT1-MMP, resulting in decreased levels of active MT1-MMP; inhibits the invasion of Matrigel by the human fibrosarcoma cell lines HT1080
Cayman Chemical PerIndoprIl 100mg
An orally active ACE inhibitor that effectively lowers blood pressure; metabolized to perindoprilat, a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro)
Cayman Chemical PodophylotoxIn 100mg
A lignan with diverse biological activities; inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM); induces mitotic arrest at the G2/M phase in CCRF CEM cells from 0.01 to 5 UG/ml; is protective against HSV-1 infection in Vero cells at 5 µM; inhibits proliferation of several DLBCL cell lines (IC50s = 0.0098-0.017 µM); a starting material in the semisynthesis of etoposide and teniposide
Cayman Chemical Daclatsvr 50mg
An NS5A inhibitor (Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively); potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively); disrupts NS5A subcellular localization when used at a concentration of 1 nM; inhibits HCV RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM; inhibits OAT1B1 and OAT1B3 (IC50s = 1.5 and 3.27 µM, respectively)
Cayman Chemical SunItInIbmalate 50mg
A multi-kinase inhibitor; inhibits FLK1 (Ki = 9 nM), PDGFRβ (Ki = 8 nM), and FLT3; at least 10-fold selective for FLK1 and PDGFRβ over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl, and Src; inhibits VEGF-dependent FLK1 and PDGF-dependent PDGFRβ phosphorylation (IC50s = 10 and 10 nM, respectively); inhibits phosphorylation of FLT3 and FLT3-ITD (IC50s = 250 and 50 nM, respectively); decreases VEGF- and FGF-induced proliferation of HUVECs; IC50s = 30 and 700 nM, respectively); reduces tumor growth in a variety of mouse xenograft models at 20-80 mg/kg per day
Cayman Chemical Latnoprost 50mg
An FP receptor agonist and prodrug of latanoprost (free acid); induces phosphoinositide turnover in isolated human ciliary muscle and human trabecular meshwork cells, HEK293 cells expressing human ocular FP receptors, mouse NIH3T3 fibroblasts, and rat A7r5 vascular smooth muscle cells (EC50s = 313, 564, 173, 142, and 110 nM, respectively); topical ocular application reduces IOP in cynomolgus monkeys in a model of laser-induced glaucoma at 0.005% twice per day