Human Sera
Cayman Chemical GSK1838705A 50mg
An IGF-1R and IR inhibitor (IC50s = 2 and 1.6 nM, respectively); selective for IGF-1R and IR over a panel of 47 kinases (IC50s = >1,600 nM); inhibits ALK (IC50 = 0.5 nM); inhibits ligand-induced phosphorylation of IGF-1R and IR as well as phosphorylation of Akt, IRS-1, and ERK in MCF-7 breast carcinoma cells; inhibits the growth of a panel of cancer cell lines (EC50s = 24-8,378 nM); completely inhibits IGF-1-induced phosphorylation of IGF-IR, Akt, and IRS-1 as well as reduces tumor growth in the COLO 205 and NIH-3T2/LISN mouse xenograft models at ≥1 and ≥10 mg/kg, respectively; induces tumor cell apoptosis and reduces tumor growth in U87MG glioma and PC3R prostate cancer mouse xenograft models
Cayman Chemical GunosIn 5-dIphosphatesod 50mg
A purine nucleotide; precursor of GTP; has been used to study GTPases; activates the SUR2B/Kir6.1 channel in HEK293T cells in a patch-clamp assay at 100 µM
Cayman Chemical CLOrcyclIzInhydroCLOrID 100mg
A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC50 = 44 nM), preventing viral entry into host cells
Cayman Chemical DetomIdInhydrochlorIde 50mg
A selective α2-adrenoceptor agonist (Ki = 1.62 nM) that binds to α1-adrenoceptors with much weaker potency (Ki = 415 nM); primarily used as a sedative for horses in large animal veterinary medicine
Cayman Chemical 4ethylN NDImethylcathInon 50mg
A potential stimulatory designer drug of the amphetamine and cathinone chemical classes; intended for forensic purposes
Cayman Chemical 5 4 6DIchlorostrIazIn2y 50mg
An amine-reactive fluorescent protein-labeling agent; has been conjugated to IgG for use as fluorescent antibodies and as a pre-column or on-column reagent to label amino acids and amino acid-containing compounds; has been used as a derivatizing agent in the analysis of ephedrine and pseudoephedrine; ex/em = 492/513 nm, respectively
Cayman Chemical Efondpn 50mg
An L- and T-type calcium channel inhibitor; inhibits hamster Cav1.2a and human Cav3.2 (IC50s = 1.8 and 350 nM, respectively); inhibits L- and T-type calcium channels and fetal bovine serum-induced hypertrophy in isolated mouse cardiomyocytes; increases survival in a mouse model of acute myocardial infarction induced by ligation of the left coronary artery at 200 mg/kg; inhibits SARS-CoV-2 Mpro (IC50 = 38.5 µM)
Cayman Chemical Cortexolon 17apropIonAT 100mg
A peripherally selective androgen receptor antagonist; binds to AR and inhibits AR-regulated transcription in a reporter cell line in vitro; inhibits androgen-regulated lipid synthesis in primary human sebocytes; inhibits inflammatory cytokine production from primary human sebocytes and scalp dermal papilla cells; inhibits testosterone propionate-induced flank organ enlargement in Syrian golden hamsters by 84% when administered topically at 400 μg/animal
Cayman Chemical MadecasosIde 50mg
A natural triterpenoid with a wide range of reported anti-inflammatory, wound healing, and antioxidant activities; suppresses LPS-induced TNF-α production via inhibition of ERK, p38, and NF-κB activity
Cayman Chemical Docosattraenyl EthnlamID 50mg
An endocannabinoid containing docosatetraenoic acid in place of the arachidonate moiety of AEA; acts on CB1 receptors with a potency and efficacy similar to that of AEA but its specific role and relative importance as a cannabinergic neurotransmitter have not been elucidated
Cayman Chemical AlocryptopIn 50mg
An isoquinoline alkaloid; active against S. aureus, P. aeruginosa, and E. coli (MICs = 250, 125, and 125 UG/ml, respectively), P. falciparum and E. histolytica (IC50s = 5.08 and 135 µM, respectively), and a panel of seven phytopathogenic fungi (IC50s = 15.2-42.4 UG/ml)
Cayman Chemical D-OrnIthIn lactam 100mg
A building block; has been used in the synthesis of HCV NS5B inhibitors, as well as αVβ3 integrin receptor antagonists
Cayman Chemical CInamyl3 4dIhydroxyaCyn 50mg
A 5-LO inhibitor (IC50 = 15 nM); selective for 5-LO over 12-LO and 15-LO (IC50s = 500 and 300 nM, respectively); inhibits A23187-induced 5-LO product formation in isolated human PMNs, monocytes, and whole blood (IC50s = 0.5, 0.45, and 1.5 µM, respectively); increases survival in a mouse model of PAF-induced lethal shock at 3.5 mg/kg; reduces pleural levels of LTB4 in a rat model of carrageenan-induced pleurisy
Cayman Chemical NItrendIpIn 100mg
A dihydropyridine used as an antihypertensive agent due to its ability to block L-type and T-type calcium channels; also binds to adenosine A1, A2A, and A3 receptors with Ki values of 8.96, 23.0, and 8.3 µM, respectively
Cayman Chemical DodecylphosphocholIn-d38 50mg
An internal standard for the quantification of dodecylphosphocholine by GC- or LC-MS