Human Sera
Cayman Chemical O6-BenzylgunIn 50mg
An analytical reference standard categorized as a phenethylamine has been associated with fatalities and acute overdoses induces the head-twitch response in mice indicating hallucinogenic potential intended for research and forensic applications
Cayman Chemical 5O 4 4DImethoxytrItylth 50mg
A dual inhibitor of EGFR and HER2 (IC50s 23 and 17 nM respectively) selective for EGFR and HER2 over a panel of 36 kinases (IC50s 250-10000 nM) inhibits proliferation of BT474 cells (GI50 17 nM) induces tumor regression in a 4-1st gastric adenocarcinoma rat xenograft model at 25 and 50 mg/kg
Cayman Chemical RamosetronhydrochlorIde 50mg
A selective potent and cell-permeable inhibitor of mTOR (IC50 4.3 nM) which blocks signaling through both mTORC1 and mTORC2 induces G1 cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines and reduces tumor growth in nude mice with PTEN-null tumors
Cayman Chemical 4methoxyaPyrroldInobutIop 50mg
A purine derivative that reversibly antagonizes aryl hydrocarbon receptor signaling (IC50 127 nM in CD34 cells) induces a 50-fold increase in human embryonic stem cells expressing CD34 (EC50 120 nM) and a 17-fold increase in stem cells that retain the ability to engraft immunodeficient mice
Cayman Chemical MoxIfloxacInhydrochlorIde 50mg
An inhibitor of GVIA iPLA2 inhibits GVIA iPLA2 by 99.9 at 0.091 mol fraction in a mixed micelle activity assay is selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows 80.8 and 36.8 inhibition respectively inhibits iPLA2B activity in cytosolic extracts from INS-1 cells overexpressing iPLA2B (IC50 ~50 nM) as well as iPLA2Y activity in mouse heart membrane fractions (IC50 ~1-3 M) inhibits glucose-induced increases in PGE2 production and insulin secretion in human pancreatic islets at 10 M inhibits thapsigargin-induced apoptosis in INS-1 cells overexpressing iPLA2B in a concentration-dependent manner reduces blood glucose levels in an intraperitoneal glucose tolerance test and incidence of diabetes and increases serum insulin levels in NOD mice at 20 mg/kg 3 times per week
Cayman Chemical SInomenInhydrochlorIde 100mg
The pharmacologically inactive optical enentiomer of (R)-LSF
Cayman Chemical ParoxetInhydrochlorIde 100mg
A potent pan-Aurora kinase inhibitor that favors Aurora A (Ki 0.6 nM) over Aurora B (Ki 18 nM) or Aurora C (Ki 4.6 nM) inhibits proliferation of clear cell renal carcinoma (IC50 2/M phase
Cayman Chemical Hexnoyl GlycIn 100mg
A pentacyclic triterpenoid with diverse biological activities active against S. aureus B. thuringiensis E. coli S. enterica and S. dysenteriae (MICs 1.9 1.9 7.8 3.9 and 1.9 Ug/ml respectively) and scavenges hydroxyl and superoxide radicals in cell-free assays at 1 mg/ml cytotoxic to DU145 prostate and MCF-7 breast cancer cells as well as U87 glioblastoma cells (IC50s 112.57 132.29 and 163.6 Ug/ml) reduces LPS-induced adherence of THP-1 monocytes to HUVECs in a co-culture model of monocyte-endothelial cell adhesion from 10-50 UM decreases liver necrosis in several mouse models of liver injury at 200 Umol/kg
Cayman Chemical aHydroxyglutarIc ACDodIu 100mg
An expected phase 1 metabolite of AKB48 intended for research and forensic applications
Cayman Chemical 1Oxyl2 2 5 5tetramthylpyr 50mg
A less active chlorine-deficient analog of W-7 the potent calmodulin antagonist (Ki 11 M) suitable for use as a control compound for understanding the specificity of other calmodulin antagonists
Cayman Chemical 1Stearoyl2MyrIstoylsngly 50mg
An analog of PCA inhibits the reuptake of serotonin (IC50 330 nM) and dopamine (IC50 2.3 M)
Cayman Chemical BromphenIramInmaleate 100mg
A metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase enhances utilization by anion transporters most commonly leading to excretion in urine and bile
Cayman Chemical MethsuxImIde 50mg
A potent orally bioavailable inhibitor of casein kinase 2 (CK2 Ki 0 38 nM) inhibits proliferation in a panel of cancer cell lines that overexpress CK2 and prevents tumor growth of breast and pancreatic cancer cell xenografts in mice
Cayman Chemical MethIcIlInsodIum salt 100mg
A metabolite of estradiol 3-sulfate that has been modified by a UDP-glucuronosyltransferase enhances utilization by anion transporters most commonly leading to excretion in urine and bile
Cayman Chemical 3MethylcytIdInmethosulfat 50mg
An active metabolite of propranolol decreases isoproterenol-induced tachycardia and vasodepression in cats (EC50 54 Ug/kg) increases heart rate in catecholamine-depleted rats at 10 and 80 Ug/kg decreases heart rate myocardial contractility and cardiac output in dogs in a dose-dependent manner reduces superoxide-induced lipid peroxidation in isolated rat hepatic microsomes (IC50 1 1 UM) and prevents superoxide-induced depletion of GSH levels in BAEC cells (EC50 1 2 UM)