Human Sera
Cayman Chemical Kaempferol-3-glucosIde 50mg
An anti-inflammatory flavonoid; inhibits IL-1β-stimulated nitric oxide and PGE2 production in patient-derived osteoarthritis chondrocytes from 20-80 UG/ml; inhibits IL-1β-stimulated expression of NOS and COX-2 and activation of MAPK and NF-κB signaling; prevents the loss of E-cadherin, the expression of vimentin, and collagen type-1 production in hydrogen peroxide-exposed human bronchial epithelial cells from 1-20 µM; inhibits EAr swelling, the production of IL-2 and IL-4, and reduces serum IgE levels in a mouse model of atopic dermatitis at 1.5 mg/kg; reduces production of ROS, collagen fiber deposition, and autophagosome formation in epithelial lung tissue of ovalbumin-challenged mice from 10-20 mg/kg
American Research Products Inc Mouse Complement C1q tumor nec
Mouse Complement C1q tumor necrosis factor-related protein 3 (C1QTNF3) ELISA kit from CUSABIO Detection Range 3 12 ng/mL-200 ng/mL Sensitivity 0 78 ng/mL Sample serum plasma tissue homogenates Method Sandwich
Cayman Chemical ValrocemIde 50mg
An anticonvulsant; protects against MES-, PTZ-, picrotoxin-, or bicuculline-induced seizures in mice (ED50s = 151, 132, 275, and 248 mg/kg, respectively); prevents sound-induced seizures in Frings audiogenic-sensitive mice (ED50 = 52 mg/kg) and MES-induced seizures in rats (ED50 = 73 mg/kg); prevents seizures in corneally kindled rats (ED50 = 161 mg/kg)
Cayman Chemical DGlucosamIn6phosphAThy 50mg
A monosaccharide intermediate of the hexosamine biosynthetic pathway; binds the GlmS riboswitch (Ki = 380 µM) and inhibits GlmS production and decreases D-GlcN-6-P levels; precursor in the biosynthesis of UDP-GlcNAc
Cayman Chemical DIoctnoyl Glycol 50mg
A DGK inhibitor (Ki = 58 μM); reduces basal and thrombin-stimulated phosphatidic acid levels in washed isolated human platelets at 30, 100, and 500 μM
Cayman Chemical R4AmIno3hydroxybutyrIc 100mg
A GABA receptor modulator; binds to GABAA and GABAB receptors (IC50s = 1 and 0.35 µM, respectively); inhibits GABA uptake in rat brain synaptosomes (IC50 = 67 µM); induces currents in a patch-clamp assay using Xenopus oocytes expressing human GABAC (EC50 = 19 µM); inhibits electrical discharges in the amygdala in a cat model of N-amidinobenzamide-induced seizures at 20 mg/animal
Cayman Chemical EburnamonIn 100mg
An indole alkaloid with vasodilator and neuroprotective activities; increases cerebral blood flow and capillary circulation in anesthetized dogs at 2.5 mg/kg; prevents scopolamine-induced amnesia in a passive avoidance test in mice at 20 mg/kg; enhances acquisition of the conditioned avoidance response induced by hypobaric hypoxia in rats at 20 mg/kg; increases the onset time to hypoxia-induced brain death in rats at 0.25 mg/kg per minute; increases survival time and inhibits decreases in body temperature induced by hypobaric hypoxia in rats at 45 mg/kg
Cayman Chemical BevntololhydrochlorIde 100mg
A β1-AR antagonist (Ki = 14.79 nM in rat cortical membranes); selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM); inhibits LVA-ICa in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM); inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induce relaxation of isolated guinea pig trachea (pA2 = 6.69); prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension at 250 mg/kg per day
Cayman Chemical Mn III ProtprphyrIn I Chl 50mg
A metalloporphyrin; induces mRNA expression of the genes encoding δ-aminolevulinate synthase and HO in chick embryo liver cells at 10 µM; manganese(III) protoporphyrin IX chloride-containing nanobialys have been used in MRI of fibrin clots in vitro; has been used in the synthesis of MnGGH
Cayman Chemical Clevdpn 50mg
An inhibitor of L-type calcium channels (IC50s = 7.1 and 78.8 nM at -40 and -80 mV, respectively, in isolated guinea pig cardiomyocytes); preferentially inhibits L-type calcium channels in isolated rat portal vein over rat left ventricle (IC50s = 427 and 20,417 nM, respectively); decreases mean arterial pressure in anesthetized normotensive or spontaneously hypertensive rats (ED30s = 316 and 58 nmol/kg, respectively)
Cayman Chemical Etofenamate 50mg
An NSAID and diethylene glycol ester form of flufenamic acid; inhibits lipoxygenase isolated from guinea pig leukocytes (IC50 = 5.3 μM) and production of PGE2 in stimulated rat peritoneal macrophages; reduces acetic acid-induced vascular permeability in mice and UV-induced erythema in guinea pigs in a dose-dependent manner at doses ranging from 40-320 and 5-20 mg/kg, respectively; inhibits inflammation in a rat model of adjuvant-induced arthritis; decreases the pain response in a silver nitrate-induced rat model of arthritis and the acetic acid-induced writhing test in mice, indicating analgesic activity
Cayman Chemical 4MethylNmethylhexnopheno 50mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical Lactoyl PhenylalnIn 50mg
A secondary metabolite; decreases food intake, body weight, and adiposity, as well as improves glucose homeostasis in a mouse model of high-fat diet-induced obesity at 50 mg/kg per day; plasma levels of lactoyl phenylalanine are increased following exercise in mice
Cayman Chemical LInoleIc AcIdpRoxID free 50mg
An essential ω-6 PUFA; the most abundant PUFA in a variety of foods; dietary sources include vegetable oils, meats, nuts, seeds, and eggs; increases migration of IEC-6 rat intestinal epithelial cells in a wound healing assay at 30 μM; rats fed a linoleate-deficient diet exhibit decreased body weight and an increased ratio of eicosatrienoate to arachidonate in liver and serum phospholipids compared with rats fed a control diet, as well as mild scaling of forepaw skin