Human Sera
Cayman Chemical 5a-ndrost-16-en-3a-ol 50mg
A pheromone with diverse biological activities; enhances GABA-activated currents in primary mouse cerebellar granule cells (EC50 = 0.4 µM); increases the amplitude of GABA-activated currents in HEK293 cells expressing human α1β2γ2 and α2β2γ2 subunit-containing GABAA receptors from 0.1-1 µM; has antidepressant-like effects in mice from 5-10 mg/kg; has anxiolytic-like effects in mice from 30-50 mg/kg; protects against PTZ- or electroshock-induced seizures in mice (ED50s = 48.9 and 21.9 mg/kg, respectively)
Cayman Chemical DGlucosamIn6phosphAThy 50mg
A monosaccharide intermediate of the hexosamine biosynthetic pathway; binds the GlmS riboswitch (Ki = 380 µM) and inhibits GlmS production and decreases D-GlcN-6-P levels; precursor in the biosynthesis of UDP-GlcNAc
Cayman Chemical Medroxyprogesteron 100mg
A progesterone receptor agonist (Ki = 241 nM); a metabolite of medroxyprogesterone 17-acetate; induces a conformational change in the C-terminal domain of the progesterone receptor (EC50 = 47.3 nM); increases alkaline phosphatase activity in T47D breast cancer cells (EC50 = 23 nM)
Cayman Chemical IonIzable LIpId 4 50mg
An ionizable cationic lipid (pKa = 6.1) and hydrogen peroxide-induced rearrangement product of the cationic lipid CA-lipid 5; CALNPs containing CA-lipid 5 and encapsulating siRNA against EGFP undergo hydrogen peroxide-induced removal of the phenylboronic acid groups from CA-lipid 5 in MCF-7 cells in vitro, generating ionizable lipid 4-containing LNPs with reduced positive charges at physiological pH, facilitating intracellular siRNA release and gene silencing; LNPs containing ionizable lipid 4 and encapsulating siRNA against PLK1 reduce tumor volume in an MCF-7 mouse xenograft model
Cayman Chemical MozavaptnhydrochlorIde 100mg
A vasopressin V2 receptor antagonist (Ki = 9.42 nM in HeLa cells expressing the human receptor); selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes, respectively; increases urine volume and decreases urine osmolality in rats from 10-30 mg/kg
Cayman Chemical PhosphatIdylethnolamInbov 50mg
A mixture of phosphatidylethanolamines isolated from bovine brain; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules
Cayman Chemical TIznIdInhydrochlorIde 50mg
An α2-adrenergic receptor agonist (α2-AR); reduces neuronal excitation induced by noxious stimuli and depresses spontaneous neuronal firing in anesthetized cats; neuronal depression can be reversed by the selective α2-AR antagonist RX781094 but not the α1-AR antagonists prazosin and WB-4101; acts as a muscle relaxant that inhibits α- and γ-rigidity in rats, reflex muscle tone in rabbits, and the linguomandibular reflex in cats
Cayman Chemical 3 4-MDPAhydrochlorIde 50mg
A lesser known psychoactive substituted amphetamine of the phenethylamine class that has been used as an internal standard for qualitative and quantitative analyses of hallucinogenic designer drugs in biological samples; intended for forensic and research purposes
Cayman Chemical SchIsntherIn B 50mg
A lignan; inhibits formation of AGEs in vitro; decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimer's disease induced by amyloid-β (1-42) at 0.1 mg/kg; increases glial expression of GLP-1 and decreases immobility time in the FST in mice; increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST
Cayman Chemical DGlutamylglycIntrIfluor 100mg
An excitatory amino acid antagonist; decreases the amplitude of EPSPs in electrically stimulated rat hippocampal slices at 200 mM; subdural administration inhibits NMDA-, kainate-, or quisqualate-induced paw biting, indicating antinociceptive activity, in mice (EC50s = 63, 9.5, and 31 µM, respectively); reduces sound-induced wild running and inhibits the clonic and tonic phases of sound-induced seizures in DBA/2 mice (ED50s = 0.058, 0.046, and 0.054 µmol, i.c.v., respectively)
Cayman Chemical ClofarabIn 100mg
A nucleoside analog that inhibits ribonucleotide reductase and DNA polymerase-α (IC50s = 65 and 3.9 nM, respectively) and is cytotoxic to K562 myelogenous leukemia cells (IC50 = 5 nM) as well as various other leukemias and solid tumors
Cayman Chemical 11-deoxy CortIcosteron 100mg
An endogenous mineralocorticoid; a metabolite of progesterone and precursor to aldosterone and corticosterone; metabolized to the neuroactive compound THDOC, which positively modulates GABAA receptors and produces effects similar to barbiturates in rats; levels increase following naloxone or CRH injection in cynomolgus monkeys; levels decrease following dexamethasone administration; increased 3.4-fold in obese and diabetic mice
Cayman Chemical Aranidipine 50mg
A Cav3.2 antagonist; inhibits inward currents in Xenopus oocytes expressing human Cav3.2 channels at 10 µM; decreases mean blood pressure and increases heart rate in SHRs at 10 mg/kg; It increases aortic and coronary blood flow and decreases blood pressure, but not heart rate, in normotensive dogs at 0.3 mg/kg; decreases blood pressure, as well as increases coronary blood flow velocity and heart contractile force, in dogs at 10 UG/kg; inhibits diet-induced increases in serum levels of total cholesterol, phospholipids, and triglycerides, as well as reduces aortic plaque area, in rabbits fed a high-cholesterol diet at 3 or 10 mg/kg
Cayman Chemical PhenylpIpRazInhydroCLOrI 100mg
The base compound from which bioactive drugs, such as the entactogen mCPP, are derived; intended for forensic applications