Human Sera
Cayman Chemical Coydals ynusuo Coydaln 100mg
An inhibitor of Src and p38 MAPK kinases (Kds 2 7 2 2 and 5 5 nM for c-Src p38a and p38B respectively) also inhibits Fyn Yes Lyn Abl Arg Ack Csk EphB2 EphB4 and Zak at 500 nM inhibits cell growth in a panel of TNBC cell lines (IC50s 6 1-260 nM) and in a patient-derived TNBC cell line (IC50 320 nM) induces cell cycle arrest at the G1/S phase MDA-MB-231 and SUM149 cells at 1 M inhibits cell motility and invasion in MDA-MB-231 and SUM149 cells at 50 nM reduces tumor growth in SUM149 and MDA-MB-231 mouse xenograft models at 10 mg/kg
Cayman Chemical 2Hydroypropyl Headecnoat 50mg
A natural non-caloric sweetener and hexose monosaccharide metabolized by gut bacteria in the colon of pigs
Cayman Chemical Chrysnthemum LInarIn 50mg
A multi-kinase inhibitor inhibits Axl and c-MET (IC50s 7 and 12 nM respectively) inhibits Axl in 293GT cells expressing Axl and c-MET in NCI H1299 NSCLC cells (IC50s 0 26 and 6 nM respectively) inhibits TYRO3 and MER (IC50s 3 5 and 1 89 nM respectively) induces complete regression of tumors in an Axl/NIH3T3 mouse xenograft model at 0 3 mg/kg induces tumor stasis and regression in an EBC-1 NSCLC mouse xenograft model at 3 and 10 mg/kg respectively reduces tumor growth in an MC38 mouse syngeneic model concomitantly with innate and adaptive immune cell activation
Cayman Chemical ClndamycIn PalmItathydroc 50mg
An esterified form of elaidic acid has been found in biodiesel produced by the microalga Botryococcus Iranian olive fruit oil and certain cultivars of O sativa black rice bran
Cayman Chemical 1Pentadecnoylracglycerol 100mg
An esterified form of trans-vaccenic acid has been used as a standard for the identification and quantification of fatty acids in Uruguayan Colonia cheese by GC-MS
Cayman Chemical PIlsIcaInIdehydrochLRIde 100mg
A dual inhibitor of VEGFR and FGFR (IC50s 5-26 and 6-35 nM for VEGFR1-3 and FGFR1-4 respectively) selective for VEGFR1-3 and FGFR1-4 over a panel of 308 kinases at 1 UM inhibits PDGFRa PDGFRB and DDR1 (IC50s 35 169 and 6 nM respectively) as well as MAP4K4 MINK1 RET SIK2 YES1 and Tie2 (IC50s 49 41 8 23 152 and 174 nM respectively inhibits FGFR-dependent proliferation in H1581 lung SNU-16 stomach and RT4 bladder cancer cells (IC50s 104 132 and 192 nM respectively) and VEGF-induced tube formation by HUVECs (IC50 33 nM) decreases tumor volume in a RT4 mouse xenograft model at 20 and 40 mg/kg reduces tumor growth and intratumor phosphorylation of FGFR in a SNU-16 mouse xenograft model at 30 mg/kg
Cayman Chemical ThIoacetazon 100mg
An ERK5 inhibitor (IC50 87 nM in an enzyme assay) selective for ERK5 over TNK2 (IC50 959 nM) but does inhibit LRRK2G2019S (IC50 26 nM) inhibits EGF-induced ERK5 autophosphorylation in HeLa cells (EC50 0.19 M)
Cayman Chemical BaloxavIr MarboxIl 100mg
An inhibitor of protein synthesis inhibits the activity of a variety of enzymes including DNase I RNase A and S1 as well as trypsin and chymotrypsin in a concentration-dependent manner inhibits replication of SARS-CoV (EC50 200 Ug/ml) and EV71 in Vero cells (EC50 2.9 UM) as well as reduces cytopathogenicity induced by HIV-1 and HIV-2 in MT-4 cells (IC50s 1.1 and 0.85 Ug/ml respectively) inhibits sanguinarine-induced apoptosis in K562 leukemia cells at 100 UM decreases CNS CD4 T cell infiltration and reduces hind limb weakness and paralysis in a mouse model of myelin oligodendrocyte glycoprotein-induced EAE at 20 mg/kg
Cayman Chemical GYKI 52466hydrochlorIde 50mg
An analytical reference standard categorized as an arylcyclohexylamine induces discriminative stimulus effects in rats comparable with those induced by PCP intended for research and forensic applications
Cayman Chemical DInotefurn 100mg
An immunomodulator with diverse biological activities a TLR7 agonist that inhibits RANKL-induced osteoclast differentiation of murine BMDMs dietary administration prevents development of TCCs in a mouse model of carcinogen-induced bladder carcinoma at 200 mg/kg twice per week reduces pulmonary collagen accumulation and BALF monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis at 100 mg/kg delays disease onset and progression and increases plasma IFN levels in a mouse model of EAE
Cayman Chemical Isoalntolacton 50mg
A topoisomerase II-a poison inhibits topoisomerase II-a by 78.9 at 20 UM selective for topoisomerase II-a over topoisomerase I providing 100 and 0 inhibition respectively at 100 UM inhibits proliferation of HCT15 T47D DU145 and HeLa cancer cells (IC50s 0.014 0.00267 0.072 and 2.46 UM respectively) induces apoptosis in T47D cells at 10 and 30 UM reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer at 12 mg/kg per day
Cayman Chemical Epmed folum Epmedn C 50mg
A TRB agonist (EC50 7 nM in a reporter assay) selectively binds to TRB over TRa (Kds 0.1 and 1.8 nM respectively) increases hepatic SR-B1 levels and serum C4 levels in mice fed normal chow or high-cholesterol diets at 97 nmol/kg reduces serum cholesterol and triglyceride levels in these same models decreases plasma cholesterol levels in a mouse model of hypothyroidism induced by an iodine-deficient diet containing 5-propyl-2-thio-uracil at 154 nmol/kg
Cayman Chemical SB-399885hydrochlorIde 50mg
A TRPV1 antagonist (Ki 72 nM for the recombinant guinea pig channel) inhibits capsaicin- or pH decrease-induced guinea pig TRPV1 channel activation (IC50s 58 and 470 nM respectively) reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs at 20 mg/kg reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain at 30 mg/kg decreases capsaicin-induced production of CGRP and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine
Cayman Chemical SRT 3025hydrochlorIde 50mg
A monosaccharide intermediate of the hexosamine biosynthetic pathway binds the GlmS riboswitch (Ki 380 UM) and inhibits GlmS production and decreases D-GlcN-6-P levels precursor in the biosynthesis of UDP-GlcNAc