Human Sera
Cayman Chemical 1Stearoyl2Oleoyl3LInoleo 50mg
A triacylglycerol; has been found in peanut and soybean oils as well as ostrich and emu oils; has been used as a substrate for soybean lipoxygenase in cell-free assays
Cayman Chemical 4-AcetamIdo ntIpyrIn 50mg
An active metabolite of metamizole; inhibits β-galactosidase activity, a marker of LXRα activity, in a yeast two-hybrid assay (IC20 = 79.9 µM); has been found as a micropollutant in reclaimed wastewater
Cayman Chemical EthopropazInhydrochLRIde 100mg
A BChE inhibitor (IC50 = 15.14 µM in human erythrocyte lysates); selective for BChE over AChE at 500 µM; binds to rat forebrain and hindbrain membrane preparations (Kis = 3.1 and 7.2 nM, respectively), which are endogenously enriched in M1 and M2 muscarinic acetylcholine receptors, respectively; decreases the intensity and increases the latency of haloperidol-induced catalepsy, a model of extrapyramidal syndrome, in rats when used in combination with ZM 241395 at 0.232 mg/kg; reduces thermal hyperalgesia in a rat model of neuropathic pain induced by sciatic nerve ligation at 20 and 30 mg/kg
Cayman Chemical 5 4 6DIchlorostrIazIn2y 100mg
An amine-reactive fluorescent protein-labeling agent; has been conjugated to IgG for use as fluorescent antibodies and as a pre-column or on-column reagent to label amino acids and amino acid-containing compounds; has been used as a derivatizing agent in the analysis of ephedrine and pseudoephedrine; ex/em = 492/513 nm, respectively
Cayman Chemical GSK205hydrobromIde 50mg
A TRPV4 and TRPA1 inhibitor (IC50s = 4.19 and 5.56, respectively, for the rat channels); inhibits GSK1016790A-induced calcium influx in whole-cell patch-clamp assays using Neuro2a cells expressing TRPV4 at 5 µM; prevents compression-induced increases in NF-κB transcriptional activity and secreted levels of IL-6 and VEGFA, as well as inhibits compression-induced fractures, abnormal cell morphology, and fissures in the intervertebral space, in primary mouse lumbar spines at 10 µM
Cayman Chemical TrIacontnoIc AcId 100mg
A very long-chain saturated fatty acid; a component of D-003
Cayman Chemical Pnaxatrol 50mg
A sapogenin with diverse biological activities; inhibits the proliferation of human DU15 prostate cancer cells (IC50 = 30 μM) and induces apoptosis by increasing production of ROS and decreasing mitochondrial membrane potential; reduces ischemia and reperfusion-induced myocardial dysfunction, increases LVDevP and GSH levels, and decreases cardiac LDH, CK, and MDA levels in isolated rats at 5 mg/kg for seven consecutive days prior to injury; decreases fasting blood glucose levels in KKAy insulin-resistant mice at 0.2% in chow for 6 weeks
Cayman Chemical GastrodIa elta Gastrodn 100mg
A phenolic glycoside with diverse biological activities; reduces Aβ42-induced cell death of rat hippocampal neurons and BV-2 mouse microglia; improves learning and memory in various transgenic mouse models of Alzheimer's disease; reduces motor deficits and loss of dopaminergic neurons in a rat model of Parkinson's disease; reduces seizure duration and intensity in a rat model of pentylenetetrazole-kindling chronic epileptic seizures from 50-200 mg/kg; increases social interaction and decreases marble burying and grooming behaviors, as well as restores inhibitory synaptic transmission and GAT1 and α5 subunit-containing GABAA expression in the basolateral amygdala in a mouse model of valproic acid-induced autistic-like phenotypes at 100 mg/kg; increases biomechanical bone strength in a rat model of dexamethasone-induced osteoporosis; inhibits ethanol-induced hepatocellular apoptosis and restores liver function in a rat model of alcoholic liver disease
Cayman Chemical RhodIola rosea RosavIn 50mg
A diglycoside with diverse biological activities; scavenges DPPH radicals in a cell-free assay (IC50 = 5.86 UG/ml); inhibits the proliferation of NCI H69, NCI H526, and NCI H446 SCLC cells at 5-100 µM; inhibits concanavalin A- or anti-CD3 and anti-CD28 antibody-induced growth of Jurkat T cells (IC50s = 80 and 74 µM, respectively) and reduces TRAIL levels in isolated mouse splenic T cells at 0.5, 5, and 50 µM; reduces ferroptosis-related mitochondrial changes and increased levels of 4-HNE and MDA in type II alveolar epithelial cells, as well as reduces lung tissue iron levels, in a rat model of intratracheal PM2.5-induced lung injury at 100 µM
Cayman Chemical Esomeprazole 50mg
An H+/K+-ATPase inhibitor; reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay; inhibits histamine-induced gastric acid secretion in rats at 30 mg/kg, s.c.
Cayman Chemical BetazolehydrochlorIde 100mg
A histamine H2 receptor agonist; induces acid secretion in isolated human gastric glands (EC50 = 120 µM); increases pepsin and acid levels in gastric juice in dogs at 3-10 mg/kg
Cayman Chemical 3-O-MethylgunosIn 100mg
An antiviral nucleoside analog; inhibits viral plaque formation and viral RNA synthesis in vaccinia virus-infected Vero cells at 10 µM
Cayman Chemical Pnax gInseng PnaxadIol 50mg
A triterpenoid sapogenin; inhibits the growth of HepG2, A549, MCF-7, and HCT116 cancer cells (IC50s = 63.20, 40.88, 61.96, and 92.53 µM, respectively); reduces tumor growth in an HCT116 mouse xenograft model at 30 mg/kg; inhibits HBV DNA replication in HepG 2.2.15 cells (IC50 = 148.15 µM); decreases the escape latency in the MWM in an APP/PS1 mouse model of Alzheimer’s disease at 50 mg/kg
Cayman Chemical TebIpenmhydrate 100mg
A carbenapenem antibiotic; active against a panel of clinical isolates from a variety of bacterial species (MIC50s = ≤0.0039-8 UG/ml); inhibits β-lactamase; decreases the number of CFUs in the lungs in a mouse model of penicillin-resistant S. pneumoniae infection at doses ranging from 0.32 to 3.2 mg/kg