Human Sera
Cayman Chemical BaloxavIr MarboxIl 100mg
A prodrug form of the antiviral baloxavir acid; inhibits CEN and CEN/RdRp activity in cell-free assays (IC50s = 530 and 340 nM, respectively); prevents mortality in a mouse model of influenza A and B viral infection at 5 or 50 mg/kg twice in a single day; reduces lung viral titers, body weight loss, and mortality in a mouse model of influenza A and B viral infection when administered 72 hours post-infection at 50 mg/kg
Cayman Chemical HydroxyfasudIl 50mg
An inhibitor of ROCK1 and ROCK2 (IC50s = 0.15 and 0.57 µM, respectively) and an active metabolite of HA-1077; decreases blood viscosity and prevents cerebral vasospasm in a canine model of subarachnoid hemorrhage at 3 and 10 mg/kg; reverses hypertension-associated dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in spontaneously hypertensive rats
Cayman Chemical CJC-1295acetate 50mg
A synthetic peptide derivative of GHRH; does not contain a DAC moiety, which reduces its half-life; increases the secretion of growth hormone in primary rat anterior pituitary cells when used from pM to µM concentrations; increases the secretion of growth hormone into rat blood at 1 µmol/kg, s.c.
Cayman Chemical BMY 14802hydrochlorIde 50mg
An atypical antipsychotic; selectively binds to σ receptors over α1-ARs and dopamine D2 receptors (IC50s = 112, 520, and 6,340 nM, respectively); inhibits the conditioned avoidance response and apomorphine-induced stereotypy in rats (ED50s = 26.4 and 33 mg/kg, respectively)
Cayman Chemical LysylysylysIntrIfluoroac 50mg
A tripeptide; has been conjugated to oleyl amine for the generation of cationic liposomes with anticancer activity
Cayman Chemical SB-206553hydrochlorIde 50mg
A 5-HT2C (Ki = 12.6 nM) and 5-HT2B receptor antagonist; selective for 5-HT2C and 5-HT2B over a panel of eight 5-HT receptor subtypes and six additional receptors (Kis = >1 µM for all); inhibits 5-HT-induced contraction of isolated rat stomach fundus (EC50 = 4.8 nM); inhibits 5-HT-induced inositol phosphate release in HEK293 cells expressing human 5-HT2C receptors (EC50 = 3.16 nM); increases the time spent in active social interaction in a social interaction test and increases punished responding in the Geller-Seifter conflict test in rats at 2 and 20 mg/kg; increases suppressed responding in a marmoset conflict model of anxiety at 15 and 20 mg/kg
Cayman Chemical CnabIdIvarIn 100mg
An analytical reference standard categorized as a phytocannabinoid; considered an impurity in the commercial preparations of cannabidiol; intended for research and forensic applications
Innovative Research Inc Single Donor Human Alzheimer's Serum
Single Donor Human Alzheimer's Serum from Innovative Research is whole blood derived. Available volumes are variable, and range from 0.5ml to 1.0ml per vial (you can select your exact samples from our inventory, if desired). A detailed patient history and clinical information is recorded at the time of draw, and multiple samples and plasma/serum matched sets from the same donor are often available.
Cayman Chemical MetaramInoltartrate 100mg
A vasoconstrictor; increases cardiac output, mean arterial pressure, and coronary blood flow and decreases pulse rate in a canine model of cardiogenic shock when administered at a dose of 0.05 mg/kg; increases survival in a canine model of hemorrhagic hypotension; reverses acetoxycycloheximide-induced transient amnesia in a shock avoidance test in rats
Cayman Chemical 7-NItroIndazole 50mg
A non-selective inhibitor of NOS isoforms in vitro (IC50s = 0.71, 0.78, and 5.8 µM for rat nNOS, bovine eNOS, and rat iNOS, respectively); shows good anti-nociceptive effects without affecting blood pressure via inhibition of eNOS in vivo
Cayman Chemical AmIprofos-methyl 50mg
An herbicide; reversibly decreases H. vulgare root and shoot length and inhibits in vitro paclitaxel-induced tubulin polymerization in a dose-dependent manner; completely inhibits tubulin polymerization in Hemanthus endosperm cells at a concentration of 0.1 μM; inhibits calcium accumulation in corn mitochondria (ID50 = 140 nM) and induces a 3-fold increase in the rate of calcium efflux from rat liver mitochondria at a concentration of 100 nM; inhibits the growth of P. falciparum (IC50 = 3.5 μM); completely inhibits microtubule polymerization in P. falciparum trophozoites at a concentration of 20 μM
Cayman Chemical AsoxImechlorIde 50mg
An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning
Cayman Chemical DImethIndenmaleate 100mg
A histamine H1 receptor antagonist (Ki = 1.5 nM); selective for histamine H1 receptors over M1 mAChRs and 5-HT receptor subtype 5-HT2A (Kis = 64 and 2,400 nM, respectively); alone or in combination with icodextrin decreases adhesions between the abdominal wall and intraperitoneal viscera and local vascularization following surgical-induced abdominal trauma in rabbits at 0.1 mg/kg
Cayman Chemical LIpId III-45 50mg
An ionizable cationic lipid; has been used in the generation of LNPs for the delivery of mRNA in vivo; LNPs containing lipid III-45 and encapsulating a luciferase mRNA reporter accumulate in liver and adipose tissue in mice; LNPs containing lipid III-45 have been used to deliver an mRNA sequence encoding an antibody targeting claudin-18.2 to mice and reduce tumor volume in an MDA-MB-231 mouse xenograft model
Cayman Chemical AgomelatIn 100mg
A melatonin receptor agonist (Kis = 0.14 and 0.41 nM for MT1 and MT2, respectively) and 5-HT2B and 5-HT2C antagonist (Kis = 0.26 and 0.71 nM, respectively); inhibits the 5-HT2-mediated penile erection response in rats at 40 mg/kg; increases extracellular levels of noradrenaline and dopamine in the frontal cortex of freely moving rats at 20-80 mg/kg; reduces immobility time in the forced swim test and increases the amount of time spent in the open arms of the elevated plus maze in mice in a transgenic neuroendocrine model of depression at 10 mg/kg