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Protein interaction antibody pairs are sets of antibodies that are known to be capable of detecting specific protein - protein interactions; they can be used together in an immunoassay.
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The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4 5-bisphosphate to 1D-myo-inositol 1 4 5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane Mutations in this gene have been found in autoinflammation antibody deficiency and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3
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This gene encodes one member of a family of translation repressor proteins The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E) which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5 end of mRNAs Interaction of this protein with eIF4E inhibits complex assembly and represses translation This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling resulting in its dissociation from eIF4E and activation of mRNA translation
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