Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 647 Rabbit anti-Human CD204
This gene encodes class A macrophage scavenger receptors which produce three isoforms (1 2 and 3) via alternative splicing These trimeric integral membrane glycoproteins are macrophage-specific and involved in various processes like atherosclerosis Alzheimer s disease and host defense Isoforms 1 and 2 mediate the endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite having the necessary domain cannot internalize modified LDL due to altered intracellular processing and trapping within the endoplasmic reticulum Isoform 3 also inhibits the function of isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages
ABclonal Technology 488 Rabbit anti-Human IL9
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells This cytokine stimulates cell proliferation and prevents apoptosis It functions through the interleukin 9 receptor (IL9R) which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes The gene encoding this cytokine has been identified as a candidate gene for asthma Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness
ABclonal Technology PE Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology PE Rabbit anti-Human PTH1R mAb
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology 647 Rabbit anti-Human TrkA
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family This kinase is a membrane-bound receptor that upon neurotrophin binding phosphorylates itself and members of the MAPK pathway The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes Mutations in this gene have been associated with congenital insensitivity to pain anhidrosis self-mutilating behavior mental retardation and cancer Alternate transcriptional splice variants of this gene have been found but only three have been characterized to date
ABclonal Technology 594 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 488 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology 647 Rabbit anti-Human IgD
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells where it is coexpressed with IgM The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases
ABclonal Technology PE Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 488 Rabbit anti-Human CD93
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker The encoded protein was once thought to be a receptor for C1q but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells The intracellular cytoplasmic tail of this protein has been found to interact with moesin a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton
ABclonal Technology 700 Rabbit anti-Human CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 610 Rabbit anti-Human CD22
Predicted to enable CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in B cell activation negative regulation of B cell receptor signaling pathway and regulation of endocytosis Located in early endosome and recycling endosome
ABclonal Technology 594 Rabbit anti-Human IL-5
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31
ABclonal Technology 647 Rabbit anti-Human CD40
This gene is part of the TNF-receptor superfamily and encodes a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation The transcription factor AKNA regulates the receptor and its ligand which is important for cell interactions TNFR2 interacts with this receptor mediating signal transduction The receptor-ligand interaction is critical for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple alternatively spliced variants encoding different isoforms have been identified