Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human DLL4
This gene is a homolog of the Drosophila delta gene The delta gene family encodes Notch ligands that are characterized by a DSL domain EGF repeats and a transmembrane domain
ABclonal Technology PE Rabbit anti-Mouse CD8a mAb
Enables identical protein binding activity Acts upstream of or within several processes including cytotoxic T cell differentiation defense response to virus and positive regulation of calcium-mediated signaling Located in external side of plasma membrane Is expressed in several structures including endocrine gland exocrine gland genitourinary system gut and hemolymphoid system gland Orthologous to human CD8A (CD8a molecule)
ABclonal Technology PE Rabbit anti-Mouse CD44 mAb
This gene enables hyaluronic acid and type II TGF-beta receptor binding contributing to cytokine binding and receptor activity It regulates T cell activation protein phosphorylation and intracellular signaling Involved in Wnt signaling epithelium morphogenesis and wound healing it plays a role in inflammatory response Located in the basolateral plasma membrane external plasma membrane and microvilli it is part of the macrophage migration inhibitory factor receptor complex Expressed in various systems including alimentary branchial arch CNS genitourinary and limb Human orthologs are linked to breast carcinoma multiple carcinomas and prostate cancer It is orthologous to human CD44 a molecule in the Indian blood group
ABclonal Technology Mitofilin Rabbit mAb
Enables RNA binding activity Involved in cristae formation Located in mitochondrial inner membrane Part of MICOS complex
ABclonal Technology IL9 Rabbit mAb
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells This cytokine stimulates cell proliferation and prevents apoptosis It functions through the interleukin 9 receptor (IL9R) which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes The gene encoding this cytokine has been identified as a candidate gene for asthma Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness
ABclonal Technology CYP24A1 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This mitochondrial protein initiates the degradation of 1 25-dihydroxyvitamin D3 the physiologically active form of vitamin D3 by hydroxylation of the side chain In regulating the level of vitamin D3 this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
Cayman Chemical SATB2CTerm RabbIt Monclo 100uL
An inhibitor of B-RAF and C-RAF (IC50s 41 7 and 2 nM for wild-type B-RAF B-RAFV600E and wild-type C-RAF respectively) cytotoxic to B-RAFV600E-expressing A375 and SK-MEL-28 melanoma cells (IC50s 57 and 69 nM respectively) as well as COLO 205 and HCT116 colon and B-CPAP and CAL-62 thyroid cancer cells (IC50s 116 65 43 and 479 nM respectively) reduces tumor growth in A375 SK-MEL-28 SK-MEL-2 and SK-MEL-30 mouse xenograft models
ABclonal Technology 488 Rabbit anti-Human CD74
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which when bound to the encoded protein initiates survival pathways and cell proliferation This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta) Multiple alternatively spliced transcript variants encoding different isoforms have been identified
ABclonal Technology 594 Rabbit anti-Human CD204
This gene encodes class A macrophage scavenger receptors which include three isoforms (1 2 and 3) generated by alternative splicing These trimeric membrane glycoproteins are macrophage-specific and involved in various physiological and pathological processes such as atherosclerosis Alzheimer s and host defense Isoforms 1 and 2 are functional receptors that mediate endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite containing the LDL-binding domain does not internalize modified LDL due to altered intracellular processing trapping it in the endoplasmic reticulum Isoform 3 can inhibit isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages
ABclonal Technology 594 Rabbit anti-Human CD33
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology NFYA Rabbit mAb
The protein encoded by this gene is one subunit of a trimeric complex forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes Subunit A associates with a tight dimer composed of the B and C subunits resulting in a trimer that binds to DNA with high specificity and affinity The sequence specific interactions of the complex are made by the A subunit suggesting a role as the regulatory subunit In addition there is evidence of post-transcriptional regulation in this gene product either by protein degradation or control of translation Further regulation is represented by alternative splicing in the glutamine-rich activation domain with clear tissue-specific preferences for the two isoforms
ABclonal Technology GSTA4 Rabbit mAb
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families These enzymes are involved in cellular defense against toxic carcinogenic and pharmacologically active electrophilic compounds At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified alpha kappa mu omega pi sigma theta and zeta This gene encodes a glutathione S-tranferase belonging to the alpha class The alpha class genes which are located in a cluster on chromosome 6 are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson s disease Alzheimer s disease cataract formation and atherosclerosis