Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human CD46
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I which protects the host cell from damage by complement In addition the encoded protein can act as a receptor for the Edmonston strain of measles virus human herpesvirus-6 and type IV pili of pathogenic Neisseria Finally the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 647 Rabbit anti-Human AXL
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal followed by two fibronectin type-III motifs It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6) This gene may be involved in several cellular functions including growth migration aggregation and anti-inflammation in multiple cell types The encoded protein acts as a host cell receptor for multiple viruses including Marburg Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus
ABclonal Technology 594 Rabbit anti-Human CD1d
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983]) [supplied by OMIM May 2010]
ABclonal Technology 488 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
ABclonal Technology 488 Rabbit anti-Human IL-17A
This gene encodes a member of the IL-17 receptor family and produces IL-17A a proinflammatory cytokine secreted by activated T cells IL-17A triggers pathways that lead to the production of inflammatory molecules chemokines antimicrobial peptides and remodeling proteins It plays a critical role in host defense immune modulation and tissue repair primarily by stimulating non-hematopoietic cells and attracting myeloid cells to inflammation sites IL-17A regulates NF-kappaB and MAPK pathways enhancing the expression of IL6 COX-2 and nitric oxide production It is involved in various infectious diseases inflammatory disorders and cancer Elevated levels of IL-17A are linked to chronic diseases like rheumatoid arthritis psoriasis multiple sclerosis and lung damage in COVID-19 caused by SARS-CoV-2
ABclonal Technology 647 Rabbit anti-Human IgE
IgE is the class of antibodies produced in the lungs skin and mucous membranes It may protect against parasite invasion but it is a major factor in allergic reactions The antigen-specific IgE interacts with mast cells and eosinophils triggers the release of histamine leukotrienes and other substances that lead to the itching sneezing and congestion of allergies - and the life threatening respiratory distress of asthma and anaphylactic shock
ABclonal Technology 647 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
ABclonal Technology 594 Rabbit anti-Human CDCP1
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis Alternative splicing results in multiple transcript variants of this gene
ABclonal Technology 647 Rabbit anti-Human CD8b
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acting as a coreceptor and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules The functional coreceptor is either a homodimer composed of two alpha chains or a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 beta chain isoforms Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described A pseudogene also located on chromosome 2 has been identified
ABclonal Technology PE Rabbit anti-Human CD5 mAb
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes T lymphocytes and a subset of B lymphocytes The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation Alternative splicing results in multiple transcript variants encoding different isoforms
ABclonal Technology 594 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology 488 Rabbit anti-Human CPT1A
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable) together with a carnitine-acylcarnitine translocase CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human IL-2 mAb
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4 IL7 IL9 IL15 IL21 erythropoietin and thrombopoietin The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes that is important for the proliferation of T and B lymphocytes The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7 The expression of this gene in mature thymocytes is monoallelic which represents an unusual regulatory mode for controlling the precise expression of a single gene The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease which suggests an essential role of this gene in the immune response to antigenic stimuli