Rabbit Secondary Antibodies
ABclonal Technology 488 Rabbit anti-Human NG2
A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells
ABclonal Technology PerCP Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
Jackson Immuno Research Labs RABBIT ANTI-HUMAN IGG (H+L) AL
Alexa Fluor 647-AffiniPure Rabbit Anti-Human IgG (H+L) (min X Ms Sr Prot)
ABclonal Technology 647 Rabbit anti-Human CD307b
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
Abcam Rabbit Anti-Human IgG H&L (DyLight 488) preadsorbed.
Rabbit Anti-Human IgG H&L (DyLight 488) preadsorbed.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology 647 Rabbit anti-Human CD300c
The CMRF35 antigen which was identified by reactivity with a monoclonal antibody is present on monocytes neutrophils and some T and B lymphocytes (Jackson et al 1992 [PubMed 1349532])
ABclonal Technology 488 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
ABclonal Technology 647 Rabbit anti-Human Ki67
Enables protein C-terminus binding activity Involved in regulation of chromosome segregation and regulation of mitotic nuclear division Located in chromosome nuclear body and nucleolus Colocalizes with condensed chromosome Implicated in Crohn s disease breast cancer human immunodeficiency virus infectious disease and pancreatic cancer Biomarker of several diseases including Barrett s esophagus autoimmune disease of musculoskeletal system (multiple) endocrine gland cancer (multiple) gastrointestinal system cancer (multiple) and interstitial cystitis
ABclonal Technology PE Rabbit anti-Human CD161 mAb
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation Several genes of the C-type lectin superfamily including the rodent NKRP1 family of glycoproteins are expressed by NK cells and may be involved in the regulation of NK cell function The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins a transmembrane domain and a cytoplasmic domain The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus
ABclonal Technology 488 Rabbit anti-Human IL-17A
This gene encodes a member of the IL-17 receptor family and produces IL-17A a proinflammatory cytokine secreted by activated T cells IL-17A triggers pathways that lead to the production of inflammatory molecules chemokines antimicrobial peptides and remodeling proteins It plays a critical role in host defense immune modulation and tissue repair primarily by stimulating non-hematopoietic cells and attracting myeloid cells to inflammation sites IL-17A regulates NF-kappaB and MAPK pathways enhancing the expression of IL6 COX-2 and nitric oxide production It is involved in various infectious diseases inflammatory disorders and cancer Elevated levels of IL-17A are linked to chronic diseases like rheumatoid arthritis psoriasis multiple sclerosis and lung damage in COVID-19 caused by SARS-CoV-2
ABclonal Technology APC Rabbit anti-Human CD153
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD307b
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1 The encoded protein has four extracellular C2-type immunoglobulin domains a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs This protein may be a prognostic marker for chronic lymphocytic leukemia Alternatively spliced transcript variants have been described but their biological validity has not been determined
ABclonal Technology 488 Rabbit anti-Human CPT1A
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable) together with a carnitine-acylcarnitine translocase CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human IL-2 mAb
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4 IL7 IL9 IL15 IL21 erythropoietin and thrombopoietin The protein encoded by this gene is a secreted cytokine produced by activated CD4 and CD8 T lymphocytes that is important for the proliferation of T and B lymphocytes The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7 The expression of this gene in mature thymocytes is monoallelic which represents an unusual regulatory mode for controlling the precise expression of a single gene The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease which suggests an essential role of this gene in the immune response to antigenic stimuli