Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Human CD94 mAb
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation Several genes of the C-type lectin superfamily including members of the NKG2 family are expressed by NK cells and may be involved in the regulation of NK cell function KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus Three transcript variants encoding two different isoforms have been found for this gene
ABclonal Technology 450 Rabbit anti-Human CD55
This gene encodes a glycoprotein involved in the regulation of the complement cascade Binding of the encoded protein to complement proteins accelerates their decay thereby disrupting the cascade and preventing damage to host cells Antigens present on this protein constitute the Cromer blood group system (CROM) Alternative splicing results in multiple transcript variants The predominant transcript variant encodes a membrane-bound protein but alternatively spliced transcripts may produce soluble proteins
Vector Laboratories GPA33-A33 RABBIT ANTI-HU 50UG
A33 antibody LS-C371955 is a biotin-conjugated rabbit polyclonal antibody to human A33 (GPA33) (aa22-235). Application: IHC, IHC-P, ELISA; Reactivity: Human; Format: Biotin, Unmodified
ABclonal Technology PE Rabbit anti-Human CD153 mAb
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF8 CD30 which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch This cytokine was shown to enhance cell proliferation of some lymphoma cell lines while to induce cell death and reduce cell proliferation of other lymphoma cell lines The pleiotropic biologic activities of this cytokine on different CD30 lymphoma cell lines may play a pathophysiologic role in Hodgkin s and some non-Hodgkin s lymphomas Two transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human GPRC5D
The protein encoded by this gene is a member of the G protein-coupled receptor family however the specific function of this gene has not yet been determined
ABclonal Technology PE Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens
ABclonal Technology 488 Rabbit anti-Human IL-17A
This gene encodes a member of the IL-17 receptor family and produces IL-17A a proinflammatory cytokine secreted by activated T cells IL-17A triggers pathways that lead to the production of inflammatory molecules chemokines antimicrobial peptides and remodeling proteins It plays a critical role in host defense immune modulation and tissue repair primarily by stimulating non-hematopoietic cells and attracting myeloid cells to inflammation sites IL-17A regulates NF-kappaB and MAPK pathways enhancing the expression of IL6 COX-2 and nitric oxide production It is involved in various infectious diseases inflammatory disorders and cancer Elevated levels of IL-17A are linked to chronic diseases like rheumatoid arthritis psoriasis multiple sclerosis and lung damage in COVID-19 caused by SARS-CoV-2
ABclonal Technology 488 Rabbit anti-Human CD58
This gene encodes a member of the immunoglobulin superfamily The encoded protein is a ligand of the T lymphocyte CD2 protein and functions in adhesion and activation of T lymphocytes The protein is localized to the plasma membrane Alternatively spliced transcript variants have been described
ABclonal Technology PE Rabbit anti-Human CD45 mAb
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 594 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 488 Rabbit anti-Human TROP-2
This intronless gene encodes a carcinoma-associated antigen This antigen is a cell surface receptor that transduces calcium signals Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy