Rabbit Secondary Antibodies
ABclonal Technology APC Rabbit anti-Mouse CD11a
Predicted to enable ICAM-3 receptor activity and cell adhesion molecule binding activity Involved in cell-cell adhesion Acts upstream of or within several processes including activated T cell proliferation positive regulation of T cell proliferation and positive regulation of calcium-mediated signaling Located in cell-cell junction external side of plasma membrane and immunological synapse Is expressed in heart hemolymphoid system and vault of skull Orthologous to human ITGAL (integrin subunit alpha L)
ABclonal Technology PE Rabbit anti-Mouse CD22 mAb
Enables CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in several processes including negative regulation of calcium-mediated signaling negative regulation of immunoglobulin production and regulation of B cell proliferation Located in external side of plasma membrane and neuronal cell body membrane Is integral component of plasma membrane Is expressed in several structures including alimentary system brain hemolymphoid system gland liver and biliary system and reproductive system Orthologous to human CD22 (CD22 molecule)
ABclonal Technology PE Rabbit anti-Mouse CD14 mAb
This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte macrophage cells This gene product acts as a co-receptor that binds several microbial and fungal molecules including lipopolysaccharides (LPS) This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex The product of this gene is found in two forms either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor
ABclonal Technology PE Rabbit anti-Mouse CD11b mAb
Enables complement component C3b binding activity heparan sulfate proteoglycan binding activity and heparin binding activity Contributes to cargo receptor activity Involved in several processes including central nervous system development endocytosis and positive regulation of neuron death Acts upstream of or within several processes including activated T cell proliferation leukocyte migration and microglia development Located in external side of plasma membrane and nucleus Is integral component of membrane Part of integrin alphaM-beta2 complex Is expressed in several structures including central nervous system heart lymphatic vessel thymus and yolk sac Human ortholog(s) of this gene implicated in lupus nephritis Orthologous to human ITGAM (integrin subunit alpha M)
ABclonal Technology PE Rabbit anti-Mouse CD44 mAb
This gene enables hyaluronic acid and type II TGF-beta receptor binding contributing to cytokine binding and receptor activity It regulates T cell activation protein phosphorylation and intracellular signaling Involved in Wnt signaling epithelium morphogenesis and wound healing it plays a role in inflammatory response Located in the basolateral plasma membrane external plasma membrane and microvilli it is part of the macrophage migration inhibitory factor receptor complex Expressed in various systems including alimentary branchial arch CNS genitourinary and limb Human orthologs are linked to breast carcinoma multiple carcinomas and prostate cancer It is orthologous to human CD44 a molecule in the Indian blood group
ABclonal Technology APC Rabbit anti-Mouse TNF-a
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily Members of this family are classified based on primary sequence function and structure This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation In mouse deficiency of this gene is associated with defects in response to bacterial infection with defects in forming organized follicular dendritic cell networks and germinal centers and with a lack of primary B cell follicles Alternative splicing results in multiple transcript variants
ABclonal Technology PerCP Rabbit anti-Mouse CD45
This gene encodes a protein with heparan sulfate proteoglycan binding heparin binding and protein tyrosine phosphatase activities It plays roles in lymphocyte differentiation regulation of macromolecule metabolism and signal transduction It is involved in processes such as lymphocyte activation and protein phosphorylation The protein is located on the plasma membrane focal adhesions and membrane rafts and is expressed in structures like the 3rd branchial arch alimentary system cardiovascular system and placenta It is used in studies of systemic lupus erythematosus Its human ortholog is linked to diseases like hepatitis C multiple sclerosis and severe combined immunodeficiency It is orthologous to human PTPRC (protein tyrosine phosphatase receptor type C)
ABclonal Technology PE Rabbit anti-Mouse CD14 mAb
This gene encodes a protein that plays an important role in the innate immune response and is expressed in monocyte macrophage cells This gene product acts as a co-receptor that binds several microbial and fungal molecules including lipopolysaccharides (LPS) This proteins LPS-binding activity is enhanced by the LPS binding protein (LBP) to allow binding to the TLR4-MD-2 co-receptor complex The product of this gene is found in two forms either as a soluble protein or attached to the cell surface by a glycosylphosphatidylinositol anchor
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure Rabbit Anti-Goat IgG Fc Fragment Specific
Alexa Fluor 488-AffiniPure Rabbit Anti-Goat IgG Fc Fragment Specific
ABclonal Technology FITC Rabbit anti-Mouse CD32
CD32 (Fcgr2) is a 40 kD transmembrane glycoprotein member of the immunoglobulin superfamily The extracellular region of CD32 consists of two Ig C-type domains that binds the Fc region from monomeric IgG with low affinity but binds immune complexes efficiently CD32 can mediate phagocytosis of immune complexes and modulate cell activation CD32 is expressed by Macrophages neutrophils mast cells and B cells
ABclonal Technology APC Rabbit anti-Mouse CD25 mAb
Enables interleukin-2 binding activity and interleukin-2 receptor activity Acts upstream of or within several processes including Notch signaling pathway activation-induced cell death of T cells and regulation of T cell proliferation Located in external side of plasma membrane Is expressed in bone marrow Used to study Sjogren s syndrome and inflammatory bowel disease Human ortholog(s) of this gene implicated in immunodeficiency 41 lymphopenia multiple sclerosis type 1 diabetes mellitus and type 1 diabetes mellitus 10 Orthologous to human IL2RA (interleukin 2 receptor subunit alpha)
ABclonal Technology PE Rabbit anti-Mouse CD40 mAb
Predicted to enable antigen binding activity protein domain specific binding activity and ubiquitin protein ligase binding activity Involved in B cell mediated immunity CD40 signaling pathway and cellular calcium ion homeostasis Acts upstream of or within several processes including defense response to other organism positive regulation of B cell activation and positive regulation of interleukin-12 production Located in external side of plasma membrane and intracellular membrane-bounded organelle Part of CD40 receptor complex Is expressed in several structures including alimentary system brain hemolymphoid system gland liver and biliary system and reproductive system Human ortholog(s) of this gene implicated in several diseases including Kawasaki disease autoimmune disease (multiple) end stage renal disease hyperimmunoglobulin syndrome (multiple) and non-Hodgkin lymphoma (multiple) Orthologous to human CD40 (CD40 molecule)
ABclonal Technology PE Rabbit anti-Mouse/Rat CD27
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process Involved in negative regulation of apoptotic process and positive regulation of JNK cascade Acts upstream of or within negative regulation of T cell apoptotic process Located in external side of plasma membrane Is expressed in several structures including femur hemolymphoid system intestine pituitary gland and reproductive system Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2 Orthologous to human CD27 (CD27 molecule)