Rabbit Secondary Antibodies
ABclonal Technology 450 Rabbit anti-Human CD59
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis and it is involved in lymphocyte signal transduction This protein is a potent inhibitor of the complement membrane attack complex whereby it binds complement C8 and or C9 during the assembly of this complex thereby inhibiting the incorporation of multiple copies of C9 into the complex which is necessary for osmolytic pore formation This protein also plays a role in signal transduction pathways in the activation of T cells Mutations in this gene cause CD59 deficiency a disease resulting in hemolytic anemia and thrombosis and which causes cerebral infarction Multiple alternatively spliced transcript variants which encode the same protein have been identified for this gene
ABclonal Technology 647 Rabbit anti-Human FATP1
Enables biotin transmembrane transporter activity efflux transmembrane transporter activity and long-chain fatty acid transporter activity Involved in several processes including carboxylic acid transmembrane transport glycerophospholipid biosynthetic process and lipid transport across blood-brain barrier Located in membrane Part of plasma membrane
ABclonal Technology APC Rabbit anti-Human EGFR mAb
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation Mutations in this gene are associated with lung cancer
ABclonal Technology 450 Rabbit anti-Human CD116
The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2 a cytokine which controls the production differentiation and function of granulocytes and macrophages The encoded protein is a member of the cytokine family of receptors This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes Multiple transcript variants encoding different isoforms have been found for this gene with some of the isoforms being membrane-bound and others being soluble
ABclonal Technology 500 Rabbit anti-Human CD45RA
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 488 Rabbit anti-Human CD79a
The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component surface immunoglobulin (Ig) Surface Ig non-covalently associates with two other proteins Ig-alpha and Ig-beta which are necessary for expression and function of the B-cell antigen receptor This gene encodes the Ig-alpha protein of the B-cell antigen component Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology 488 Rabbit anti-Human IL8
The protein encoded by this gene interleukin-8 (IL-8) is a CXC chemokine and major mediator of the inflammatory response IL-8 is secreted by various cells including macrophages neutrophils and T lymphocytes and acts as a chemotactic factor guiding neutrophils to infection sites It is rapidly induced by bacterial and viral products and plays a role in systemic inflammatory response syndrome (SIRS) IL-8 contributes to bronchiolitis caused by respiratory syncytial virus (RSV) and is involved in lung inflammation in cystic fibrosis It is also linked to coronary artery disease endothelial dysfunction and promotes tumor migration angiogenesis and metastasis IL-8 binds to the CXCR2 receptor increasing blood vessel permeability Elevated IL-8 levels correlate with disease severity including sepsis This gene is part of a CXC chemokine gene cluster on chromosome 4q
ABclonal Technology 594 Rabbit anti-Human CDA
This gene encodes an enzyme involved in pyrimidine salvaging The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine respectively It is one of several deaminases responsible for maintaining the cellular pyrimidine pool Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias
ABclonal Technology 647 Rabbit anti-Human IgG Fc
Predicted to enable antigen binding activity and immunoglobulin receptor binding activity Predicted to be involved in several processes including activation of immune response defense response to other organism and phagocytosis Predicted to act upstream of or within several processes including immunoglobulin mediated immune response positive regulation of hypersensitivity and positive regulation of phagocytosis Located in extracellular space
ABclonal Technology 594 Rabbit anti-Human IL23R
The protein encoded by this gene is a subunit of the receptor for IL23A IL23 This protein pairs with the receptor molecule IL12RB1 IL12Rbeta1 and both are required for IL23A signaling This protein associates constitutively with Janus kinase 2 (JAK2) and also binds to transcription activator STAT3 in a ligand-dependent manner
ABclonal Technology 647 Rabbit anti-Human CR2/CD21
This gene encodes a membrane protein which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9) Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 700 Rabbit anti-Human BCL6
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain This protein acts as a sequence-specific repressor of transcription and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL) and may be involved in the pathogenesis of DLCL Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene