Rabbit Secondary Antibodies
ABclonal Technology ITPR3 Rabbit mAb
This gene encodes a receptor for inositol 1 4 5-trisphosphate a second messenger that mediates the release of intracellular calcium The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus Knockout studies in mice suggest that type 2 and type 3 inositol 1 4 5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth
ABclonal Technology ATP5G1 Rabbit mAb
This gene encodes a subunit of mitochondrial ATP synthase Mitochondrial ATP synthase catalyzes ATP synthesis utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation ATP synthase is composed of two linked multi-subunit complexes the soluble catalytic core F1 and the membrane-spanning component Fo comprising the proton channel The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha beta gamma delta and epsilon) assembled with a stoichiometry of 3 alpha 3 beta and a single representative of the other 3 The proton channel seems to have nine subunits (a b c d e f g F6 and 8) This gene is one of three genes that encode subunit c of the proton channel Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein Alternatively spliced transcript variants encoding the same protein have been identified
ABclonal Technology DLX3 Rabbit mAb
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll) a gene expressed in the head and limbs of the developing fruit fly The Distal-less (Dlx) family of genes comprises at least 6 different members DLX1-DLX6 Trichodentoosseous syndrome (TDO) an autosomal dominant condition has been correlated with DLX3 gene mutation This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17 Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism
Abcam Rabbit F(ab')2 Anti-Mouse IgG - H&L (Biotin), pre-adsorbed.
Rabbit F(ab')2 Anti-Mouse IgG - H&L (Biotin), pre-adsorbed.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology PE Rabbit anti-Mouse CD40 mAb
Predicted to enable antigen binding activity protein domain specific binding activity and ubiquitin protein ligase binding activity Involved in B cell mediated immunity CD40 signaling pathway and cellular calcium ion homeostasis Acts upstream of or within several processes including defense response to other organism positive regulation of B cell activation and positive regulation of interleukin-12 production Located in external side of plasma membrane and intracellular membrane-bounded organelle Part of CD40 receptor complex Is expressed in several structures including alimentary system brain hemolymphoid system gland liver and biliary system and reproductive system Human ortholog(s) of this gene implicated in several diseases including Kawasaki disease autoimmune disease (multiple) end stage renal disease hyperimmunoglobulin syndrome (multiple) and non-Hodgkin lymphoma (multiple) Orthologous to human CD40 (CD40 molecule)
ABclonal Technology Nup107 Rabbit mAb
This gene encodes a member of the nucleoporin family The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC) All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized
ABclonal Technology UFM1 Rabbit mAb
UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1 MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M MIM 603173) (Komatsu et al 2004 [PubMed 15071506])
ABclonal Technology TOM70 Rabbit mAb
This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex This protein is involved in the import of mitochondrial precursor proteins The protein interacts with the SARS-CoV and SARS-Cov-2 ORF9b proteins
ABclonal Technology MUC16/CA125 Rabbit mAb
This gene encodes a membrane-tethered mucin protein involved in forming a protective mucous barrier on epithelial surfaces The protein has an extracellular domain at its amino terminus a large tandem repeat region rich in serines threonines and prolines and a transmembrane domain with a short cytoplasmic tail The repeat region includes SEA (Sea urchin sperm protein Enterokinase and Agrin) leucine-rich and ankyrin repeats forming the ectodomain A potential cleavage site is near an SEA module This protein is believed to protect epithelial cells from pathogens It is used as a cancer marker with higher expression linked to poorer outcomes
ABclonal Technology Meckelin Rabbit mAb
The protein encoded by this gene localizes to the primary cilium and to the plasma membrane The gene functions in centriole migration to the apical membrane and formation of the primary cilium Multiple transcript variants encoding different isoforms have been found for this gene Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6)
Cayman Chemical S100BCTerm RabbIt Monclo 100uL
An inhibitor of SIK2 (IC50 50s 21.63 and 6.63 nM respectively) inhibits TNF-a secretion in RAW 264.7 cells (IC50 ~2.5 UM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 UM inhibits growth of 10 ovarian cancer cell lines (IC50s 0.8-2.6 UM) and increases sensitivity of eight of them to paclitaxel halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 UM has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
ABclonal Technology NCR3 Rabbit mAb
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells The encoded protein interacts with CD3-zeta (CD247) a T-cell receptor A single nucleotide polymorphism in the 5 untranslated region of this gene has been associated with mild malaria suceptibility Three transcript variants encoding different isoforms have been found for this gene
ABclonal Technology CYP11A1 Rabbit mAb
This gene encodes a member of the cytochrome P450 superfamily of enzymes The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol steroids and other lipids This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone the first and rate-limiting step in the synthesis of the steroid hormones Two transcript variants encoding different isoforms have been found for this gene The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide
Cayman Chemical InTRleukIn12R2 RabbIt Mon 50uL
A positive allosteric modulator of AMPA receptors potentiates glutamate-induced currents in HEK293 cells expressing human GluR2 homomeric AMPA receptors (EC50 2.51 UM) as well as HEK293 cells expressing GluR1 GluR3 or GluR4 homomeric AMPA receptors increases novel object exploration in a novel object recognition test in rats at 0.3 and 1 mg/kg reduces escape latencies in the Morris water maze in aged rats
FUJIFILM BIOSCIENCES INC Anti SQSTM1/A170/p62 Rabbit 10
Sequestosome 1 SQSTM1 /A170 mouse /p62 human /ZIP rat a ubiquitin-binding protein expresses oxidative stress-dependently Abnormality of SQSTM1 leads to bone metabolic disorder obesity and Type II diabetes SQSTM1 was reported to bind LC3 which regulates autophagosome formation The protein has attracted the attention of researchers because it is believed to induce a protein from ubiquitin-proteosome system UPS to the lysosome-dependent macroautophagy autophagy system which are two major intracellular pathways for protein degradation This antibody is useful for immunofluorescence immunohistochemistry and Western blotting