Fluorescent in situ hybridization Reagents
Genscript Corporation ROR1 30-305Ig-likeFrizzled
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1) is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains highly related to those of the Trk-family receptor tyrosine kinases and by the extracellular Frizzled-like cysteine-rich domains and kringle domains which are common to receptors of the Wnt family members
Genscript Corporation ROR1 30-305Ig-likeFrizzled
ROR1 (Receptor tyrosine kinase-like orphan receptor 1) also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1) is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains highly related to those of the Trk-family receptor tyrosine kinases and by the extracellular Frizzled-like cysteine-rich domains and kringle domains which are common to receptors of the Wnt family members
Genscript Corporation FGFR1 alpha IIIcBiotin Hi
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes including cell growth differentiation angiogenesis wound healing and tumorgenesis The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development cell proliferation differentiation and migration Required for normal mesoderm patterning and correct axial organization during embryonic development normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system
Genscript Corporation FGFR1 alpha IIIcBiotin Hi
Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes including cell growth differentiation angiogenesis wound healing and tumorgenesis The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after ligand binding FGFR1 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development cell proliferation differentiation and migration Required for normal mesoderm patterning and correct axial organization during embryonic development normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system
ABclonal Technology Phospho-JAK2-Y1007/1008 Rabbit pAb
This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling. The primary isoform contains a FERM domain for receptor association, an SH2 domain for STAT binding, a pseudokinase domain, and a C-terminal kinase domain. Cytokine binding activates the kinase, which then phosphorylates and activates STAT proteins. Growth factors like TGF-beta 1 also activate this kinase, influencing gene transcription. Mutations in this gene are linked to inflammatory diseases and cancers. It is a target of IL6, involved in immune response and inflammation. Disruption of the IL6/JAK2/STAT3 pathway leads to increased cellular proliferation and myeloproliferative neoplasms. A mutation in the pseudokinase domain causes constitutive activation, leading to hypersensitivity to cytokines. This gene and its pathway are therapeutic targets for inflammatory conditions. Alternative splicing produces multiple isoforms.
ABclonal Technology Phospho-JAK2-Y1007 Rabbit pAb
This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling. The primary isoform contains a FERM domain for erythropoietin receptor association, an SH2 domain for STAT binding, a pseudokinase domain, and a C-terminal kinase domain. Cytokine binding triggers autophosphorylation and activation of this kinase, which then phosphorylates STAT proteins. Growth factors like TGF-beta 1 also activate this kinase, leading to STAT translocation to the nucleus to influence gene transcription. Mutations in this gene are linked to inflammatory diseases and cancers. It is a target of IL6, which regulates immune responses and inflammation. Disruption of the IL6/JAK2/STAT3 pathway causes increased cell proliferation and myeloproliferative neoplasms. A mutation in the pseudokinase domain causes constitutive activation, making it hypersensitive to cytokine signaling. Alternative splicing produces multiple isoforms.
ABclonal Technology Phospho-JAK2-Y1007 Rabbit pAb
This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling. The primary isoform contains a FERM domain for erythropoietin receptor association, an SH2 domain for STAT binding, a pseudokinase domain, and a C-terminal kinase domain. Cytokine binding triggers autophosphorylation and activation of this kinase, which then phosphorylates STAT proteins. Growth factors like TGF-beta 1 also activate this kinase, leading to STAT translocation to the nucleus to influence gene transcription. Mutations in this gene are linked to inflammatory diseases and cancers. It is a target of IL6, which regulates immune responses and inflammation. Disruption of the IL6/JAK2/STAT3 pathway causes increased cell proliferation and myeloproliferative neoplasms. A mutation in the pseudokinase domain causes constitutive activation, making it hypersensitive to cytokine signaling. Alternative splicing produces multiple isoforms.
ABclonal Technology Phospho-JAK2-Y1007/1008 Rabbit pAb
This gene encodes a non-receptor tyrosine kinase involved in cytokine and growth factor signaling. The primary isoform contains a FERM domain for receptor association, an SH2 domain for STAT binding, a pseudokinase domain, and a C-terminal kinase domain. Cytokine binding activates the kinase, which then phosphorylates and activates STAT proteins. Growth factors like TGF-beta 1 also activate this kinase, influencing gene transcription. Mutations in this gene are linked to inflammatory diseases and cancers. It is a target of IL6, involved in immune response and inflammation. Disruption of the IL6/JAK2/STAT3 pathway leads to increased cellular proliferation and myeloproliferative neoplasms. A mutation in the pseudokinase domain causes constitutive activation, leading to hypersensitivity to cytokines. This gene and its pathway are therapeutic targets for inflammatory conditions. Alternative splicing produces multiple isoforms.