Reverse transcriptase-IN-1 (Compound 12z) is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. It demonstrates antiviral activity against HIV-1 IIIB, E138K, and K103N mutants, with EC50 values of 3.4 nM, 4.3 nM, and 3.6 nM respectively. It also exhibits an IC50 of 13.7 nM against the HIV-1 reverse transcriptase enzyme. Studies indicate significantly improved oral bioavailability and potential as an orally bioavailable candidate for human HIV-1 infection research.
- Potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor
- Demonstrates antiviral activity against various HIV-1 mutants
- Exhibits IC50 of 13.7 nM against HIV-1 reverse transcriptase enzyme
- Improved oral bioavailability
- Potential candidate for human HIV-1 infection research