Apoptosis Reagents and Kits
Cayman Chemical Cel-Based asy Hoechst Dye 50uL
A dual peptide GCGR and GLP-1R agonist induces cAMP production in BHK-21 cells expressing human GCGR or GLP-1R (EC50s 1.83 and 0.92 pM respectively) reduces body weight and cumulative food intake in a mouse model of diet-induced obesity from 3-5 nmol/kg reduces body weight hepatic fat accumulation and fibrosis and plasma ALT levels in a mouse model of NASH induced by a high-fat high-fructose and high-cholesterol diet
Abcam Human KIF22 knockout HEK-293T cell lysate.
Human KIF22 knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human HADHA knockout HEK-293T cell lysate.
Human HADHA knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human Plcb1 (Phospholipase C beta 1) knockout HeLa cell lysate.
Human Plcb1 (Phospholipase C beta 1) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human EIF2AK2 (PKR) knockout A549 cell lysate.
Human EIF2AK2 (PKR) knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen m-3M3FBS
Chemical. CAS 200933-14-8. Formula C16H16F3NO2S. MW 343.4. m-3M3FBS is a cell permeable and specific activator of phospholipase C PLC that has been shown to stimulate the PLC-mediated intracellular Ca2 release, inositol phosphates production and superoxide generation in various cell types. It activates all PLC isotypes beta2, beta3, gamma1, gamma2 and delta1 in vitro, but not heterotrimeric G proteins, PI 3-kinase or PLD. m-3M3FBS also affects calcium homeostasis independently of PLC activation. m-3M3FBS induces apoptosis in tumor cells through caspase activation, down-regulation of XIAP and intracellular calcium signaling. m-3M3FBS has been shown in vitro to trigger mitochondrial damage and activate NLRP10 a bona fide inflammasome binding to Asc and Caspase-1 in keratinocytes. NLRP10 acts also as inflammasome in intestine epithelial cells and protects against autoinflammation in the gut.
Abcam Human TNFRSF1A (TNF Receptor I) knockout HeLa cell lysate.
Human TNFRSF1A (TNF Receptor I) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human CELF1 (CUG-BP1) knockout HEK-293T cell lysate.
Human CELF1 (CUG-BP1) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
AdipoGen Fc hGrancalcin h rec
Recombinant protein. Human Grancalcin aa 1-217 is fused at the N-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Lyophilized. Contains PBS. Grancalcin is a member of a new family of proteins named penta-EF-hand PEF, which contains five repetitive EF hand motifs. PEF proteins form a unique group including calpain, sorcin, grancalcin, ALG-2 apoptosis-linked gene-2 protein and peflin. The penta-EF hand members are Ca2-binding proteins implicated in regulating cell migration, apoptosis and the mobilization of immune cells. Senescent cells accumulate in the bone marrow and secrete factors, termed senescence-associated secretory phenotype SASP, that can promote skeletal aging. Recently, senescent neutrophils and macrophages in the bone marrow were shown to be critical cell types during skeletal aging releasing Grancalcin GCA to promote such aging.
Apexbio Technology LLC Annexin V-APC/DAPI Apoptosis Kit 20tests
Annexin V-APC/DAPI Apoptosis Kit allow discrimination between cells at various stages of apoptosis and cell death Annexin V is a calcium-dependent phospholipid-binding protein which specifically binds to phosphatidylserine (PS) Under normal conditions PS is located on the inner surface of the cell membrane lipid bilayer but during early apoptosis PS translocates from the inner leaflet to the outer leaflet of the plasma membrane becoming exposed to the extracellular environment By using Annexin V-APC labeling apoptotic cells can be detected easily through flow cytometry or fluorescence microscopy within 15-30 minutes Additionally this kit includes the nuclear stain DAPI which specifically binds to double-stranded DNA to emit blue fluorescence Normally DAPI cannot penetrate intact cell membranes In late apoptotic and dead cells DAPI can cross the compromised membrane to stain the nucleus
ABclonal Technology Caspase-1 Rabbit pAb
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Abcam Human PAK2 knockout HeLa cell lysate.
Human PAK2 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human TNF knockout THP-1 cell lysate.
Human TNF knockout THP-1 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human Lgals9 (galectin 9/Gal-9) knockout THP-1 cell lysate.
Human Lgals9 (galectin 9/Gal-9) knockout THP-1 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Sigma Aldrich Fine Chemicals Biosciences Annexin V from human place1MG
Annexin V from human place1MG
