Cell-permeable ceramide analog. N-Acetylsphingosine is a biologically active, cell-permeable ceramide analog. It inhibits cell proliferation and induces monocytic differentiation of HL-60 cells and induces apoptosis. It stimulates protein phosphatase 2A4, activates MAP kinase and SAP kinase and induces PKCδ and ε translocation. Physiological levels of C2 ceramide, produced by the action of a PAF:sphingosine CoA-independent transacetylase, have been detected in HL-60 cells. Alternative Name: N-Acetyl-D-erythro-sphingosine. Formula: C20H39NO3. MW: 341.5. CAS Number: 3102-57-6. Purity: ≥98% (TLC). Appearance: White solid. Solubility: Soluble in 100% ethanol (>25mg/ml) or DMSO (>50mg/ml). Use/Stability: Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. Long Term Storage: -20°C