Apoptosis Reagents and Kits
Abcam ANNEXIN V/ANXA5-CY5 APOPTOSIS ..
ANNEXIN V/ANXA5-CY5 APOPTOSIS ..
The product is subject to the following: Abcam Restricted Use Statement
Abcam Hinokitiol, Iron chelator antio x idant, 50MG
MW 164.2 Da, Purity >98%. Iron chelator antioxidant. Inhibits UVB-induced apoptosis. Cytotoxic to cancer cells. Antioxidant, anti-inflammatory and antitumor. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Biotium Apoptosis and Necrosis Quantitation Kit Plus (50 assays)
The Apoptosis and Necrosis Quantitation Kit Plus is a simple, convenient assay for quantifying apoptotic (green; Abs/Em: 490/515 nm) and necrotic (red; Abs/Em with DNA: 528/617 nm) cells within the same cell population by flow cytometry or fluorescence microscopy. Apoptosis is accompanied by phosphatidylserine (PS) translocation from the inner to the outer leaflet of the plasma membrane. Exposed PS is recognized by Annexin V, a calcium-dependant high-affinity phospholipid-binding protein. CF488A conjugated Annexin V stains apoptotic cells green. CF488A is spectrally similar to fluorescein (FITC), but is brighter and more photostable. Necrosis results from severe cellular injury causing loss of plasma membrane integrity. Ethidium homodimer III (EthD-III), a membrane impermeant high-affinity DNA binding dye stains cells with compromised membranes red. It is superior option to propidium iodide (PI) or ethidium homodimer I due to higher DNA affinity and fluorescence quantum yield.
Abcam Human AK1 knockout HeLa cell lysate.
Human AK1 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human SYP (Synaptophysin) knockout HEK-293T cell lysate.
Human SYP (Synaptophysin) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human NT5E knockout A-431 cell lysate.
Human NT5E knockout A-431 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Annexin A5/Annexin V Rabbit pAb
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications.
Abcam CRT0066101, protein kinase D inhibitor, 10MG
MW 411.3 Da, Purity >99%. Potent and selective protein kinase D inhibitor (IC₅₀ values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro. Also available in simple stock solutions (ab146740) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human EEA1 knockout HeLa cell lysate.
Human EEA1 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical ANTIBODY Z-FF-FMK 10mg
An inhibitor of cathepsin B (Ki = 2.7 nM); inhibits cell division, cell cycle progression, DNA replication, and chromosome decondensation in isolated T. niger fertilized embryos at 100 µM; prevents Aβ40-induced increases in cathepsin L activity, as well as prevents Aβ40-induced apoptosis, DNA fragmentation, and increases in cleaved PARP levels, in primary rat cortical neurons at 10 µM; inhibits quinolinic acid-induced nuclear translocation of NF-κB, as well as inhibits quinolinic acid-induced increases in phosphorylated IκBα and IKKα levels, in the unilateral striatum in rats at 5 nmol/animal
Abcam Human CPT1A knockout HEK-293T cell lysate.
Human CPT1A knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC RK-33 2mg 1070773-09-9
RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Abcam Human WDR4 knockout HeLa cell lysate.
Human WDR4 knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Annexin A2 Rabbit pAb
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms.
Abcam Belnacasan (V x -765), 5MG
MW 509 Da, Purity >98%. Potent and selective inhibitor against caspase-1 with Ki of 0.8 nM. Orally absorbed. Also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM, in vitro. Inhibits LPS-induced IL-1β production in collagen-induced arthritis mouse model, in vivo.
The product is subject to the following: Abcam Restricted Use Statement