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An agonist of GLP-1R (Ki 1.1 nM for the human receptor) induces cAMP accumulation in CHO-K1 cells expressing human GLP-1R (EC50 0.06 nM) decreases blood levels of glucose and increases blood levels of insulin in an oral glucose tolerance test in Zucker diabetic obese rats at 1 mg/animal per week reduces blood levels of GIP plasma levels of triglycerides and body weight in the same model
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A cardiac glycoside with cardiotonic and antiarrhythmic activities inhibits Na /K -ATPase in an isoform-specific biphasic manner with IC50 values of 0.298 and 410 UM for the high- and low affinity human erythrocyte isoenzymes respectively and 1.18 and 28.5 UM for the high- and low affinity porcine cerebral cortex isoenzymes respectively increases contractility and rhythmicity in isolated guinea pig heart in a concentration-dependent manner a degradation product of digoxin
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A multi-kinase inhibitor inhibits VEGFR2 PDGFRB FLT3 and c-Kit (IC50s 1.12 0.13 0.63 and 0.14 nM respectively) and is selective for these kinases over RET and AMPKa1 (IC50s 74.1 and 352.2 nM respectively) inhibits VEGF-induced proliferation of HUVECs (IC50 31 nM) decreases VEGF-induced capillary tube formation in HUVECs at 1 UM reduces FBS-induced migration of HUVECs at 0.01 or 0.1 UM reduces tumor volume and growth alone and in combination with gefitinib in an HCC827 NSCLC mouse xenograft model at 80 mg/kg per day
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More