Modifying Enzyme Buffers
Modifying Enzyme Buffers
Thermo Scientific™ Buffers for RNA Transctription and Post-Transcriptional Modifications
Thermo Scientific enzymes for in vitro transcription are designed for efficient and reliable RNA synthesis. These enzymes cover the entire synthesis workflow from template preparation to post-transcriptional modifications, ensuring optimal performance and high yields of synthesized RNA.
Thermo Scientific™ Agarase (0.5 U/μL)
Specifically digests the agarose polysaccharide core, which allows for gentle yet efficient recovery of DNA or RNA fragments from low melting point agarose.
Thermo Scientific™ Pyrophosphatase, inorganic (0.1 U/μL)
Catalyze the hydrolysis of inorganic pyrophosphate to two orthophosphates.
Thermo Scientific™ Alkaline Phosphatase Buffer-1 (5X)
For cellular and molecular biology applications
Thermo Scientific™ Kinase buffer II (5X)
For cellular and molecular biology applications
Thermo Scientific™ Kinase buffer I (5X)
For cellular and molecular biology applications
Revvity Health Sciences Inc HTRF Stimulation Buffer #1 (5X), 8 mL
HTRF Stimulation Buffer #1 (5X), 8 mL
AdipoGen VX-745
Chemical. CAS 209410-46-8. Formula C19H9Cl2F2N3OS. MW 436.3. VX-745 is a potent inhibitor of p38α MAPK IC50=10nM with 20-fold selectivity over p38β and 1000-fold selectivity over closely related kinases, ERK1, MK2 and JNK1-3. p38α is a member of the mitogen-activated protein kinase MAPK family of serine/threonine protein kinases and is widely expressed in endothelial, immune or inflammatory cells and plays a central role in the regulation of proinflammatory cytokine production including TNF-α, IL-1β and IL-6. VX-745 is an anti-inflammatory agent that blocks IL-1β and TNF-α release in whole blood in vitro with IC50 values of 150 and 180nM, respectively. VX-745 showed anti-inflammatory efficacy in an animal model of rheumatoid arthritis and recently anti-neuroinflammatory potential in prevention of early-stage Alzheimers diseases AD.
AdipoGen Ruxolitinib phosphate salt
Chemical. CAS 1092939-17-7. Formula C17H18N6 . H3O4P. MW 306.4 . 98.0. Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 IC50=322nM. Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro.
Sigma Aldrich Fine Chemicals Biosciences Pyruvate Kinase from rabbi
Pyruvate kinase from rabbit muscle catalyzes an ATP-dependent phosphorylation of glycolate to yield 2-phosphoglycolate.
Sigma Aldrich Fine Chemicals Biosciences Pyruvate Kinase from rabbi
Pyruvate Kinase (PK) is a glycolysis enzyme and has four isozymes L R M1 and M2. The L isozyme is localized in gluconeogenic tissues particularly in the liver. Whereas the R and M1 are localized in the adult skeletal muscles heart brain and erythrocytes respectively. M2 is localized in the nucleus of the cells.