Modifying Enzymes
ABclonal Technology T4 RNA Ligase 2, truncated KQ
T4 RNA Ligase 2, truncated KQ (T4 Rnl2tr R55K, K227Q), specifically catalyzes the ligation of a 5-adenylated DNA or RNA to the 3 OH end of an RNA molecule. This enzyme-mediated ligation does not require ATP but necessitates a pre-adenylated adapter. T4 RNA Ligase 2, truncated KQ, a double-point mutant of T4 RNA Ligase 2 with R55K and K227Q substitutions, significantly reduces the non-specific ligation of RNA (such as concatenation or self-circularization) compared to T4 RNA Ligase 2, truncated, while maintaining enzyme activity similar to that of T4 RNA Ligase 2, truncated.
New England Biolabs, Inc. Thymine-DNA Glycosylase (TDG)-500 units
Thymine-DNA glycosylase (TDG) catalyzes the hydrolysis of the N-glycosidic bond of thymine or uracil mispairs opposite guanine that arise from spontaneous deamination events of 5-methylcytosine (5mC) and cytosine, respectively.The excision of the mispaired thymine or uracil base leaves an abasic (AP) site that can then be chemically or enzymatically cleaved.
- Active on dsDNA
- Monofunctional glycosylase that removes dT or dU nucleobases mispaired with dG to create an AP site
- Removes 5-formylcytosine, 5-carboxylcytosine, 5-hydroxymethyluracil, ethenocytosine, 5-fluorouracilIsolated from a recombinant source
- Supplied with 10X TDG Reaction Buffer
Medchemexpress LLC HY-110115 10mg Medchemexpress, TC-Mps1-12 CAS:1206170-62-8 Purity:>98%
Medchemexpress, HY-110115 10mg TC-Mps1-12 CAS:1206170-62-8 TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical N-Oleoyl ProlIn 25mg
An endogenous N-acyl amine that is decreased in lumbar spinal cord after capsaicin administration (1 UG/10 µl) and has surfactant properties (critical micelle concentration = 4.8 µM)
Medchemexpress LLC TC-Mps1-12 | 1206170-62-8 | 99.8% | 324.38 | 100 MG
TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM. It inhibits the growth of pMps1 cell lines and A549 cells in a dose-dependent manner, exhibiting good pharmacokinetic properties.
- Potent and selective Mps1 inhibitor
- Inhibits the growth of pMps1 cell lines with IC50 values of 131 nM in autophosphorylation assay
- Inhibits the growth of A549 cells in a dose-dependent manner in vivo, showing 47% tumor growth inhibition at 100 mg/kg without body weight loss
- Exhibits good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng h/mL at an oral dose of 25 mg/kg
ABclonal Technology Xanthine Oxidase (XDH) Rabbit mAb
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.
Biotang Inc Staphylokinase Recombinant, produced in E.Coli is a non-glycosylated polypeptide chain containing 136 amino acids and having a molecular weight of 15.5 kd.
Staphylokinase Recombinant, produced in E.Coli is a non-glycosylated polypeptide chain containing 136 amino acids and having a molecular weight of 15.5 kd.
Cayman Chemical Oleoyl-L-carnItInchlorIde 1mg
A long-chain acylcarnitine and GlyT2 inhibitor (IC50 = 340 nM); selective for GlyT2 over GlyT1 (IC50 = >10,000 nM); plasma levels are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality
Medchemexpress LLC ADAMTS-5 Inhibitor 50mg | 929634-33-3 | 449.92 g·mol⁻¹ | C16H11ClF3N3OS3 | 50 MG
ADAMTS-5 Inhibitor is a small-molecule research compound that potently inhibits ADAMTS-5 (aggrecanase-2) with an IC50 of 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4. It is supplied as a solid with a reported purity of 99.59%, a molecular weight of 449.92 g·mol⁻¹, and formula C16H11ClF3N3OS3. For research use only.
- Potent ADAMTS-5 inhibition (IC50 1.1 μM).
- Greater than 40-fold functional selectivity over ADAMTS-4.
- High reported purity of 99.59%.
- Supplied as a solid; also available as a 10 mM solution in DMSO.
- Available in multiple milligram packaging options (5 mg-500 mg) and larger quantities on request.
- Intended for research use only.
Worthington Biochemical Corporation DEOXYRIBONUCLEASE II 80KU
A dialyzed, lyophilized powder. 9025-64-3
ABclonal Technology Acetyl-CoA Carboxylase
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA the rate-limiting step in fatty acid synthesis There are two ACC forms alpha and beta encoded by two different genes ACC-alpha is highly enriched in lipogenic tissues The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA Multiple alternatively spliced transcript variants divergent in the 5 sequence and encoding distinct isoforms have been found for this gene
Amsbio LLC Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum/ 5 IU
Heparinase I (EC 4.2.2.7) from Flavobacterium heparinum 5 IU
Cayman Chemical 3-Phenylpropanoyl-Coenzyme A
A medium-chain and phenyl-substituted acyl CoA; has been used as an enzymatic substrate in potential screening assays for MCAD deficiency in newborn-derived primary fibroblasts
ABclonal Technology T4 DNA Ligase
T4 DNA Ligase catalyzes the formation of a phosphodiester bond between juxtaposed 5 phosphate and 3 hydroxyl termini in duplex DNA or RNA. This enzyme will join blunt end and cohesive end termini as well as repair single stranded nicks in duplex DNA and some DNA/RNA hybrids. T4 DNA ligase will seal nicks for these DNA substrates. T4 DNA Ligase is applicable to cloning of restriction fragments and to joining linkers and adapters to blunt-ended DNA.
Abcam Bano x antrone dihydrochloride (AQ4N), Topoisomerase II inhibitor, 10MG
MW 517.4 Da, Purity >97%. Bioreductive AQ4 precursor. Topoisomerase II inhibitor. Converts under hypoxia to DNA-affinic mitoxantrone (ab141041) structural analog. Induces DNA intercalation. Shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement