Blood Gas Analyzers and Accessories
Cayman Chemical ANTIBODY ICA 27243 50mg
An activator of Kv7.2/Kv7.3 subunit-containing channels; enhances rubidium efflux in an agonist-induced rubidium efflux assay using CHO cells expressing Kv7.2/Kv7.3 (EC50 = 0.38 µM); selective for Kv7.2/Kv7.3 channels over Kv7.4 channels (EC50 = 7.1 µM); 100-300-fold selective for Kv7.2/Kv7.3 over Kv7.3/Kv7.5 channels; selective for Kv7.2/Kv7.3 channels over a panel of neurotransmitter receptors and Nav1.2 at 10 µM, as well as GABAA receptors and high voltage-activated calcium channels at 30 µM; protects against maximal electroshock-induced seizures in a rat model of epilepsy (ED50 = 1.5 mg/kg); prevents amphetamine- and chlordiazepoxide-induced hyperactivity without affecting basal locomotor activity in a mouse model of manic-like hyperactivity at 10 mg/kg
