General Clinical Chemistry Analyzers and Accessories
Abcam GSK-690693 hydrochloride, ATP-competitive pan-Akt kinase inhibitor, 25MG
MW 425.5 Da, Purity >99%. Novel ATP-competitive pan-Akt kinase inhibitor (IC₅₀ values are 2, 13 and 9 nM for Akt1, 2 and 3 respectively). Also exhibits some inhibition of AMPK, PKA and PAK and PKC isoforms (IC₅₀ < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Vistusertib (AZD2014), 50MG
MW 462.5 Da, Purity >98%. Novel potent and selective mammalian rapamycin (mTOR) inhibitor (IC₅₀ = 2.8 nM). Highly selective against multiple PI3K isoforms. Also targets P-Akt (IC₅₀ = 80 nM) and pS6 (IC₅₀ = 200 nM). An oral inhibitor with potential anti-neoplastic activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam 7-Cl-O-Nec1, metabolically stable RIP1 inhibitor, 25MG
MW 277.7 Da, Purity >98%. Necrostatin-1 (ab141053) analog with superior selectivity and metabolic stability in blocking RIP1. No off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1. Higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC₅₀ = 210 nM vs. EC₅₀ = 490 nM).
The product is subject to the following: Abcam Restricted Use Statement
Bellco Glass, Inc. Glass chamber with hose connections & compression fitting for 12mm OD probes. Used with any 12mm OD probes - to measure parameters from process such as an off line pH. Type 1a Borosilicate glass chamber Two hose barb connections Replacement ca
Glass chamber with hose connections & compression fitting for 12mm OD probes. Used with any 12mm OD probes - to measure parameters from process such as an off line pH. Type 1a Borosilicate glass chamber Two hose barb connections Replacement ca
Nova Biomedical Corporation FLEX2 AUTOSMP STM ROTARY VALVE
Bioprofile Flex2 Autosampler STM Rotary Valve to 3-Way Valve Tubing Assembly.
Hach Company Cell Cap for 5500sc Silica and Phosphate Analyzers (Replacement spare for colorimeter cell)
Hach cell cap (MPN 6767800) is a replacement cap designed for the 5500sc silica and phosphate analyzers. It covers and helps protect the analyzer's colorimeter cell and is intended as a maintenance spare for replacement when the original cap is damaged or worn.
- Replacement cap for colorimeter cell.
- Helps protect optical surfaces from contamination.
- Intended as a maintenance spare for affected analyzers.
Abcam Fluo-4 AM, Fluorescent labeling reagent, 1MG
Fluo-4 AM, Fluorescent labeling reagent (ab241082) is part of the reagents, controls & accessories range. Abcam offers high-quality biological reagents and tools including antibodies, proteins, assays, cell lines and lysates.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Ponesimod, sphingosine-1-phophate receptor agonist, 1MG
MW 461 Da. Ponesimod is a potent agonist of sphingosine-1-phophate receptor. (S1P₁/EDG-1; IC₅₀s = 6, >10,000, 2,068, 1,956, and 142 nM for S1P₁-S1P₅, respectively, in a radioligand binding assay). Selectively activates S1P₁ in a GTPγS assay (EC₅₀s = 5.7, >10,000, 105, 1,108, and 59.1 nM, for S1P₁-S1P₅, respectively).
The product is subject to the following: Abcam Restricted Use Statement
Abcam RITA, p53 activator, 5MG
MW 292.4 Da, Purity >98%. p53 activator. Tricyclic thiophene derivative that binds to p53 and induces its accumulation in tumor cells. Prevents p53-HDM2 (MDM2) interaction in vitro and in vivo and affects p53 interaction with several negative regulators. Induces expression of p53 target genes and apoptosis in various tumor cell lines expressing wild-type p53.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY2940680 (Taladegib), 50MG
MW 512.5 Da. Potent Hedgehog signaling pathway inhibitor. Smoothened antagonist. Inhibits growth of cancer cell lines containing a disease-relevant Smoothened gene mutation. Has anti-tumor activity in animal models.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SIS3, Smad3 inhibitor, 5MG
MW 490 Da, Purity >98%. Potent and selective Smad3 inhibitor. Selectively inhibits TGF-beta 1/ALK5-induced Smad3 phosphorylation. Inhibits the TGF-beta 1 effect on type I procollagen expression at the transcriptional levels via the Smad3-binding site. Has no effect on Smad2, p38, MAPK, ERK or PI 3-kinase signaling.
The product is subject to the following: Abcam Restricted Use Statement
Abcam CUR 61414, Hedgehog signaling pathway antagonist, 25MG
MW 550.7 Da, Purity >98%. Novel, cell permeable Hedgehog signaling pathway antagonist (IC₅₀ = 100-200 nM). Selectively binds to smoothened (Smo) (Ki = 44 nM). Blocks the formation of and induces the regression of basaloid lesions in skin punches and shrinks UV-induced basaloid lesions in adult mouse skin. Inhibits proliferation and induces apoptosis in tumor cells without affecting non-tumor cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Monochlorobimane, 5MG
MW 226.66 Da, Purity >=98%. Monochlorobimane is a cell-permeant probe for quantifying glutathione levels in cells. It is essentially nonfluorescent until it reacts with a thiol group. It readily reacts with several low molecular weight thiols, including cysteine, glutathione, N-acetylcysteine, mercaptopurine, peptides and plasma thiols. The glutathione conjugate of monochlorobimane has an excitation/emission maxima ~394/490 nm.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY2874455, FGF/FGFR inhibitor, 5MG
MW 444.3 Da, Purity >98%. Potent FGF/FGFR inhibitor. Inhibits in vitro autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC₅₀ < 6.4 nM). Exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.
The product is subject to the following: Abcam Restricted Use Statement