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MAGE-A1-derived peptide acetate is a short peptide sequence derived from the MAGE-A1 protein. It functions as a tumor-specific antigen, capable of being recognized and activated by cytotoxic T lymphocytes (CTLs). This activation initiates an immune response against tumor cells that express MAGE-A1, ultimately leading to their lysis and death. This compound is valuable for research in tumor immunity.
Derived from MAGE-A1 protein.
Acts as a tumor-specific antigen.
Activates cytotoxic T lymphocytes (CTLs).
Generates an immune response against MAGE-A1 expressing tumor cells.
Induces tumor cell lysis and death.
Used in tumor immunity studies.
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Insulin β Chain Peptide (15-23) is one of the earliest antigenic epitopes to which CD8 T-cells respond. This peptide is for research use only and not intended for patient use. It is a white to off-white solid with a purity of 95.68%.
Exhibits high purity at 95.68%
For research use only
Stimulates IFN-γ and TNF-α production in CD8 T-cells in vitro
Promotes rapid diabetes development in specific mouse models in vivo
White to off-white solid appearance
Features amino acid sequence Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly (LYLVCGERG)
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A RIPK3 inhibitor (IC50 = 20.8 nM); inhibits basal RIPK3 autophosphorylation and TNF-α- or TRAIL-induced necroptosis in HT-29 cells at 5 µM; inhibits TNF-α Smac mimetic- and Z-VAD-induced necroptosis in HeLa and NCI-H2009 cancer cells ectopically expressing RIPK3
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Immunogen: Synthetic peptide from the internal region of 15-LO-2 · To be used in conjunction with Cayman’s 15-LO-2 polyclonal antibody (Catalog No. 10004454) to block protein-antibody complex formation during immunochemical analysis of 15-LO-2.
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RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. It works by preventing RAGE from binding with several of its key ligands, including HMGB-1, S100P, and S100A4. This peptide also exhibits anti-tumor and anti-inflammatory activities.
Prevents RAGE from binding with several important ligands (HMGB-1, S100P, S100A4)
Exhibits anti-tumor activities
Exhibits anti-inflammatory activities
Reduces NFκB activation in cancer cells
Inhibits glioma tumor growth
Blunts airway reactivity, airway inflammation, and goblet cell metaplasia in asthma models
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A histamine H1 receptor antagonist (IC50 180 nM) selective for the histamine H1 receptor in a panel of 30 receptors in vitro at 100 UM prevents microvascular extravasation (ED50 185 Ug/kg i v ) bronchospasm (ED50 4 6 Ug/kg i v ) and systemic anaphylaxis (ED50 0 2 Ug/kg p o ) induced by subcutaneous histamine in guinea pigs prevents anaphylaxis induced by subcutaneous administration of ovalbumin or DNP in sensitized rats at 7 6 and 6 0 mg/kg respectively
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