Custom Peptides
Cayman Chemical LIdocaIn-d10 10mg
An internal standard for the quantification of lidocaine by GC- or LC-MS
Cayman Chemical 8-ChloroadenosIn 10mg
A nucleoside analog and an active metabolite of 8-chloro cAMP; inhibits RNA but not DNA synthesis in cells at 10 µM; is cytotoxic to patient-derived multiple myeloma cells; reduces tumor growth by 50% in an HCT116 colorectal cancer mouse xenograft model at 50 mg/kg
Cayman Chemical CarbamazepIn 10 11epoxIde 10mg
An active metabolite of carbamazepine; has anticonvulsant activity against maximal electroshock-induced seizures in mice; has been found in wastewater effluent
Cayman Chemical Blonanserin 10mg
A mixed antagonist at dopamine D2, D3, and serotonin 5-HT2A receptors (Kis = 0.14, 0.49, and 0.81 nM, respectively) that also binds to 5-HT6 (Ki = 11.7 nM); developed as a novel antipsychotic that displays 20- and 94-fold higher affinity for D2 receptors compared to haloperidol and risperidone, respectively
Cayman Chemical SplItomIcIn 10mg
A small molecule inhibitor of Sir2p HDAC activity, displaying higher activity in vivo (minimal inhibitory concentration = 0.49 µM) than in vitro (IC50 = 60 µM); has diverse effects on mammalian cells
Cayman Chemical CardIogenol ChydrochLRIde 10mg
Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM
Cayman Chemical 15keto ClopROSnl Isopropy 10mg
A potential impurity in commercial cloprostenol isopropyl ester preparations
Cayman Chemical BNTXmaleate 10mg
A δ1-opioid receptor antagonist (Ki = 0.1 nM); selective for the δ1-opioid receptor over the δ2-, μ-, and κ-opioid receptors (Kis = 10.8, 13.3, and 58.6 nM, respectively); decreases proliferation of primary mouse splenic B cells and the production of IL-2 and IL-4 by primary mouse splenic T lymphocytes at 1 and 10 µM; has antinociceptive activity in the tail-flick test in mice (ED50 = 46.4 pmol/animal) and decreases the antinociceptive activity of DPDPE at 6.3 pmol/animal; decreases the number of capsaicin-induced coughs in mice at 0.3-3 mg/kg; reduces the number of parasitized red blood cells in a mouse model of chloroquine-resistant P. chabaudi infection at 10 mg/kg
Cayman Chemical 3R 8S-FalcarIndIol 10mg
A polyacetylene with diverse biological activities; active against M. tuberculosis strain H37Ra (MIC = 6.25 μg/ml); cytotoxic to MCF-7, H1299, and HepG2 cells (IC50s = 29.4, 22.1, and 23.6 μM, respectively); has algicidal activity against H. circularisquama at 2 and 4 μM
Cayman Chemical aContoxIn ImItrIfluoroace 10mg
A conotoxin and an antagonist of α7 nAChRs (IC50 = 220 nM); selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM); administration of paclitaxel in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model; intracerebroventricular administration of α-conotoxin ImI induces seizures in rats at 20 nmol/animal
Cayman Chemical 1 3-DIcaffeoylquInIc AcId 10mg
A polyphenol; decreases the expression and protein levels of iNOS at 10 µM in HCASMCs treated with a cytokine mixture; decreases protein levels of tyrosinase and MITF in B16F1 cells; inhibits melanogenesis in B16F1 cells and decreases tyrosinase activity in cell lysates at 25 µM; reduces triglyceride levels in sodium oleate-induced hyperlipidemic HepG2 cells at 20 and 40 µM
Cayman Chemical CeftIbutenhydrate 10mg
A broad spectrum cephalosporin antibiotic; inhibits the growth of B. catarrhalis, H. influenzae, pathogenic Neisseria, Streptococcus, penicillin-susceptible S. pneumoniae, and eleven Enterobacteriaceae strains (MICs = 0.25, ≤0.06, ≤0.06, 0.5-1, 4, and ≤0.06-0.5 μg/ml, respectively); active against E. coli expressing β-lactamase type I, III, and V and K. oxytoca expressing β-lactamase type IV (MICs = 8, 0.25, 0.5, and ≤0.06 μg/ml, respectively) as well as a panel of eight bacterial stains expressing plasmid-encoded extended spectrum β-lactamases, including E. coli CTX-M and K. pneumoniae SHV-2 (MICs = 1 and 0.25 μg/ml, respectively); reduces the number of mice killed within 6 days of a K. pneumoniae, E. coli, S. pneumoniae, or S. aureus infection at 0.125, 2, 1,024, and >512 mg/kg, respectively
Cayman Chemical 3hydroxy3methylglutarylCo 10mg
An intermediate in several metabolic pathways; conversion to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway; can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase; an intermediate in the degradation of leucine
Cayman Chemical GlucagonhydrochlorIde 10mg
A peptide hormone; produced from proglucagon in pancreatic α cells; stimulates glucose production ex vivo in isolated rat hepatocytes; stimulates glucose output from perfused rat livers via increases in gluconeogenesis and glycogenolysis and decreases in glycolysis; increases plasma glucose levels in rats; secretion is suppressed in response to food intake in normal rats and humans but is maintained or elevated in humans with type 2 diabetes
Cayman Chemical 1 2DIstearoyl3Decnoylrac 10mg
A triacylglycerol; contains stearic acid at the sn-1 and sn-2 positions and decanoic acid at the sn-3 position