An inhibitor of dipeptidase (dehydropeptidase I) inhibits human renal dipeptidase (Ki 0.7 M) porcine dipeptidase (IC50 0.11 M) and bacterial metallo-b-lactamase CphA from A. hydrophila (IC50 178 M) protects primary porcine renal proximal tubular epithelial cells from vancomycin-induced nephrotoxicity and apoptosis (200 g/ml) protects mice from systemic infection by S. aureus E. coli and P. aeruginosa when administered in combination with imipenem inhibits renal metabolism of imipenem to prolong its half-life