Custom Peptides
Cayman Chemical Otospon astatus upaton 10mg
An EPA metabolite and activator of KCa1 1/BK channels increases the potassium current amplitude by 15-fold in isolated rat cerebral artery VSMCs at 50 nM has negative chronotropic effects in NRCMs (EC50 1-2 nM) and prevents calcium-induced increases in NRCM spontaneous beating
Cayman Chemical 1 2 3TrI10 ZHeptadecenoyl 10mg
An esterified form of linoelaidic acid has been found in H sabdariffa essential oil as well as biodiesel produced from sea mango seed oil
Cayman Chemical RebaudIosIde D 10mg
A derivative and metabolite of coumarin with diverse biological activities inhibits growth of human ACHN renal A549 lung HCT15 colon and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells at 250-300 Ug/ml increases ROS production and halts the cell cycle in KB human oral carcinoma cells has antidepressant-like activity in a rat model of depression induced by chronic unpredictable mild stress at 15 and 30 mg/kg used as a ratiometric pH indicator with ex/em 330 and 370/460 nm at low and high pH respectively
Cayman Chemical CAY10740hydrochlorIde 10mg
A DGAT-1 inhibitor (IC50 15 nM) selective for DGAT-1 over DGAT-2 and ACAT-1 (IC50s 10 and 12 M respectively) inhibits triacylglycerol synthesis in HuTu 80 cells (IC50 4 nM) reduces plasma triacylglycerol levels the ratio of triacylglycerolsdiacylglycerols and body weight in a mouse model of diet-induced obesity at 20 mg/kg
Cayman Chemical 1 3DIstarol2ElaIdol Gl 10mg
A signal-off fluorescent probe for detection of mitochondrial membrane potential disruption has been used with a variety of cell damage and cell death markers to classify nine stages of cell death using flow cytometry has been used as a quencher to detect serine phosphorylation and tyrosine dephosphorylation PTMs in QRET and mTR-FRET applications ex/em 659/666 nm respectively
Cayman Chemical Forsytha fructus Phlyrn 10mg
An internal standard for the quantification of oclacitinib by GC- or LC-MS
Cayman Chemical 10 11-Cl-BBQ 10mg
A peptide PAR4 agonist (EC50 30 M in Xenopus oocytes expressing human PAR4 receptors) corresponds to residues 1-6 of the amino terminal tethered ligand sequence of mouse PAR4 and residues 60-65 of the full-length sequence induces calcium release in wild-type and PAR3-/- mouse platelets and in human platelets triggers [3H]inositol phosphate release from KOLF cells expressing human PAR4
Cayman Chemical DerythroLthreo Lysosphngo 10mg
A dual inhibitor of EGFR and HER2 (IC50s 23 and 17 nM respectively) selective for EGFR and HER2 over a panel of 36 kinases (IC50s 250-10000 nM) inhibits proliferation of BT474 cells (GI50 17 nM) induces tumor regression in a 4-1st gastric adenocarcinoma rat xenograft model at 25 and 50 mg/kg
Cayman Chemical 1Oleoyl2hydroxysnglycero 10mg
An acyl-CoA that contains a cyclohexane group formed through conversion of CHC by a succinyl-CoA transferase and degraded by a dehydrogenase converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver
Cayman Chemical FruquIntInIb 10mg
An analytical reference standard categorized as a cathinone intended for research and forensic applications
Cayman Chemical 2propyl4PentenoIc AcId 10mg
A partial agonist of CB1 and CB2 (Kis 55 4 48 3 and 45 5 nM for rat CB1 human CB1 and human CB2 respectively) exhibits anti-hyperalgesic and anti-allodynic properties in rat models of chronic neuropathic and inflammatory pain
Cayman Chemical RocuronIumbromIde 10mg
A taurine-conjugated form of CDCA serum levels increase approximately 5-fold in within two hours and begin to decrease within four hours during an oral lipid tolerance test in humans serum levels are increased in patients with liver cirrhosis and may serve as a marker of disease progression
Cayman Chemical Myrislignan 10mg
An internal standard for the quantification of lauric acid by GC- or LC-MS
Cayman Chemical SavolItInIb 10mg
A DHFR inhibitor (Ki 11.5 nM for the P. falciparum enzyme) with antimicrobial activity is active against P. vulgaris S. aureus and S. pyogenes in vitro (MICs 4 1 and 2 g/ml respectively) has anticoccidial activity when administered alone or in combination with sulfaquinoxaline
Cayman Chemical SynthetIc Isoflavon 10mg
An inhibitor of GlyT1 (IC50 3 nM) selective for GlyT1 over GlyT2 (IC50 10 UM) as well as over NMDA receptors and the inhibitory glycine receptor at 100 UM increases prefrontal cortical levels of glycine in rats at 10 mg/kg reverses MK-801-induced persistent latent inhibition in a mouse model of schizophrenia