Custom Peptides
Cayman Chemical CInamyl3 4dIhydroxyaCyn 10mg
A sodium channel blocker with high-affinity and selectivity for inhibiting human Nav1 8 sodium channels (IC50 8 nM when stimulated at half-maximal inactivation and IC50 79 nM at a resting state) dose dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models
Cayman Chemical 5-APDBhydrochlorIde 10mg
A non-enzymatic free radical peroxidation product of arachidonic acid acts as a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM respectively approximately ten-fold more potent than 8-iso-PGF2a in a whole blood platelet aggregation inhibition assay
Cayman Chemical nglada oxbugna ngltn 10mg
A synthetic intermediate has been used in the synthesis of peptide enzyme substrates and lysine cationic surfactants
Cayman Chemical BIsdemethoxycurcumIn 10mg
A S-nitrosothiol that acts as an NO donor under acidic conditions decomposes with a half-life of 6 minutes in 0 1 M phosphate buffer pH 5 0 at 37 C relaxes phenylephrine-constricted rat aortic strips 35 and 8 at pH 6 0 and 7 4 respectively
Cayman Chemical Isoxnthohumol 10mg
A fungal macrolactone that has cytotoxic activity against select cancer cell lines inhibits cytokine-induced iNOS expression (IC50 9.5 UM) in vitro and reduces proinflammatory gene expression in a mouse model of rheumatoid arthritis
Cayman Chemical Notoptrygum ncsum Nodakn 10mg
An inhibitor of dipeptidase (dehydropeptidase I) inhibits human renal dipeptidase (Ki 0.7 M) porcine dipeptidase (IC50 0.11 M) and bacterial metallo-b-lactamase CphA from A. hydrophila (IC50 178 M) protects primary porcine renal proximal tubular epithelial cells from vancomycin-induced nephrotoxicity and apoptosis (200 g/ml) protects mice from systemic infection by S. aureus E. coli and P. aeruginosa when administered in combination with imipenem inhibits renal metabolism of imipenem to prolong its half-life
Cayman Chemical 2-trns-HexadecenoIc AcId 10mg
A phospholipid has been found in rat brain as 37 of the arachidonic acid-containing LPA species a precursor to 1-AG binds to the LPA2/EDG4 receptor (EC50 10 nM) prevents TNF-a and IL-6 secretion in LPS-stimulated wild-type but not Lpa2-/- dendritic cells decreases differentiation of HT-29 human colon carcinoma cells to goblet cells
Cayman Chemical 20 S-ProtopnaxatrIol 10mg
A monoacylglycerol increases daunomycin accumulation in Caco-2 cells induces apoptosis in thymocytes
Cayman Chemical JatrorrhIzInchlorIde 10mg
A biotinylated form of lauric acid an intermediate in the synthesis of N-biotinylated phenylarsonous acids
Cayman Chemical 1 2DIpalmItoyl3lnoelaIdoy 10mg
A cyclohexenecarboxylic acid an intermediate in the biosynthesis of aromatic amino acids in plants and microorganisms a precursor in the synthesis of oseltamivir decreases lipid droplet accumulation in HepG2 cells and 3T3-L1 adipocytes at 80 UM increases the levels of phosphorylated AMPK and decreases the levels of MID1IP1 in HepG2 and 3T3-L1 adipocytes at 40 UM decreases inflammation and demyelination in a mouse model of EAE at 50-200 mg/kg and reduces symptom progression at 100 mg/kg
Cayman Chemical 2a-MnobIose 10mg
A minor component of the oligomycin complex that acts as an inhibitor of the mitochondrial F1FO-ATP synthase which leads to cell death
Cayman Chemical RaltegravIrpotasIum salt 10mg
Immunogen Full length human TRF2 Host Mouse Isotype IgG1K Cross Reactivity ( ) Human mouse muntjac rat Application(s) ChIP ELISA FC (intracellular) ICC IF IHC (frozen sections and paraffin-embedded tissue) IP and WB